Biggest First-Round Tourney Upsets

C.J. McCollum scored 30 points and Lehigh upset Duke 75-70 to become the second No. 15 seed to beat a No. 2 during a wild Friday in the NCAA tourney. The Mountain Hawks are the sixth No. 15 seed to pull off the trick. Duke dropped its first tournament game for only the second time in the past 16 years, and this one occurred just 55 miles from its campus.

Kyle O'Quinn (10) had 26 points and 14 rebounds, making several key plays in the closing minutes, and Norfolk State held on to stun Missouri 86-84 in the West Regional. The Spartans, who won the MEAC, made their first trip to the NCAA tournament a memorable one, becoming the fifth No. 15 seed to beat a No. 2 and the first since fellow conference member Hampton in 2001.

After Morehead's Demonte Harper (22) reigned a go-ahead 3-pointer with 4.2 seconds left, the Cardinals had a chance to win it, but Morehead's Kenneth Faried (35) blocked Mike Marra's attempt before the buzzer. Louisville was gone after its first game for the second straight year and tiny Morehead State of Kentucky -- enrollment 9,000 at the base of the Appalachian Mountains -- had its first tournament win since 1984.

Ohio was just a No. 9 seed for the MAC tourney, but not only earned a spot in the NCAAs, it recorded day one's biggest upset, knocking off Big East power Georgetown. Senior Armon Bassett (0) collected 32 points on 10-of-19 shooting for the Bobcats, who won their first NCAA tourney game in 27 years.

Danero Thomas hit a 15-footer as the buzzer sounded and 13th-seeded Murray State stunned No. 4 seed Vanderbilt 66-65 in its 2010 tournament opener. It was the school's first victory in the NCAA tournament since a 78-75 win over North Carolina State in 1988.

If Northwestern State guard Jermaine Wallace took the shot 10 times, it's hard to imagine he'd make it more than once. After hauling in a loose-ball rebound in the waning seconds, Wallace found himself trapped in the corner. He took one dribble toward the baseline, then chucked up a fadeaway three that splashed through the net with a half second left to give the Demons a 64-63 win. This prayer capped off the 14th-seeded Demons' comeback from a 17-point deficit with 8 1/2 minutes left.

Led by their wisecracking, radio-show-hosting coach, Tom Brennan, and star forward Taylor Coppenrath, the No. 13 seed Catamounts knocked out fourth-seeded Syracuse, which was just two years removed from a national title. Senior guard T.J. Sorrentine swished a long three-pointer to boost Vermont's lead to four with just over a minute left in overtime. Syracuse's Gerry McNamara missed a desperation three with under a second remaining, and the Catamounts prevailed.

Bucknell certainly fit the underdog billing. The Bison had only five scholarship players and had to borrow the band from Northern Iowa because theirs was on spring break. Bucknell's Chris McNaughton banked in the winning hook shot with 10.5 seconds to go, and Wayne Simien missed a jump shot at the buzzer. It was the first opening-round loss for the Jayhawks in their past 21 tries and the first tournament win ever for the Bison (or any team from the Patriot League, for that matter).

Indiana State recorded its first NCAA tournament win since the days of Larry Bird. The Sycamores overcame a 13-point second-half deficit to shock the fourth-seeded Sooners in this overtime victory. Indiana State was led by Matt Renn, who scored 22 points.

This first-round shocker produced one of the most indelible images in NCAA tournament history: Hampton coach Steve Merfeld pumping his arms and legs in jubilation as a player lifts him off the ground. Hampton is the fourth (and most recent) No. 15 seed to knock off a 2.

Harold "The Show" Arceneaux. The name instantly evokes NCAA tournament nostalgia, and for good reason: Arceneaux earned instant fame by dropping 36 points in Weber State's first-round shocker over the Tar Heels. Then-North Carolina coach described Arceneaux's performance with one word: "Unconscious."

Homer Drew named the play "Pacer" -- in honor of the NBA team from which he stole it. With 2.5 seconds remaining and Valparaiso trailing by 2, the coach drew up the play to get a shot for his best play -- and son -- Bryce Drew. Ninety-four feet away from the basket, Jamie Sykes tossed a long baseball pass to Bill Jenkins, who caught the ball in mid air and immediately advanced the ball to Drew, who nailed the game-winning three and took a celebratory dive across the floor.

As stunning upsets go, this one was about as anticlimactic as they get. The Eagles may have entered the game as 30-point underdogs, but they dominated the Gamecocks in the 13-point win. The epic win was the first tournament win in Coppin State's school history.

Princeton's Pete Carril had announced that he would be retiring following the season less than a week before this game. UCLA, the defending national champion, represented the iconic coach's last chance to pull off an NCAA tournament shocker. Amazingly, the Tigers shut out the Bruins over the final six minutes. Then in the waning seconds, Steve Goodrich found Gabe Lewullis on a classic Princeton backdoor cut and the rest is history.

Prior to this game, Santa Clara coach Dick Davey spoke honestly about his team's outlook: "Our chances are not good. It could get ugly." But the Broncos had a skinny freshman point guard from Canada by the name of Steve Nash. Nash hit six straight foul shots down the stretch, and Santa Clara held on for this massive upset.

Richmond had already established itself as a giant killer by beating Charles Barkley's Auburn team in 1984 and Bob Knight's defending national champion Hoosiers in 1988, but this was the school's crowning achievement. The Spiders became the first No. 15 seed ever to beat a No. 2, knocking off a talented Syracuse team lead by All-American Billy Owens.

Digger Phelps' Irish came into this game as 17-point favorites, but they couldn't contain hot-shooting Arkansas-Little Rock. In the second half, the Trojans shot 15-for-19 from the field and 9-for-11 from the free throw line en route to the memorable upset.

Kevin Mackey's Vikings stunned Bobby Knight's Hoosiers with an aggressive "Run n' Stun" style. Cleveland State advanced to the Sweet 16, where it lost to David Robinson and Navy.