| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Bryan Scott | BUF | 16 | 46 | 13 | 1.0 | 0.0 | 0 | 1 | 6 | 2 | 43 | 2 |
| 2 | Jamaal Anderson | IND | 15 | 12 | 12 | 3.0 | 2.0 | 0 | 1 | 1 | 0 | 0 | 1 |
| Geno Atkins | CIN | 16 | 26 | 21 | 7.5 | 5.0 | 2 | 2 | 3 | 0 | 0 | 1 | |
| Jordan Babineaux | TEN | 16 | 68 | 21 | 0.0 | 1.0 | 1 | 1 | 7 | 1 | 97 | 1 | |
| Nick Barnett | BUF | 16 | 78 | 52 | 3.0 | 7.0 | 1 | 0 | 5 | 3 | 80 | 1 | |
| Kevin Burnett | MIA | 16 | 83 | 22 | 2.5 | 6.5 | 0 | 0 | 3 | 1 | 34 | 1 | |
| Donald Butler | SD | 16 | 77 | 18 | 2.0 | 6.5 | 2 | 1 | 2 | 1 | 2 | 1 | |
| Jairus Byrd | BUF | 16 | 75 | 23 | 1.0 | 2.5 | 3 | 1 | 8 | 3 | 88 | 1 | |
| Colin Cloherty | JAC | 4 | 0 | 0 | 0.0 | 0.0 | 0 | 1 | 0 | 0 | 0 | 1 | |
| Nate Collins | JAC | 12 | 0 | 10 | 0.5 | 0.0 | 0 | 1 | 1 | 0 | 0 | 1 | |
| Aaron Curry | OAK | 16 | 48 | 19 | 0.0 | 2.5 | 0 | 2 | 5 | 0 | 0 | 1 | |
| Carlos Dunlap | CIN | 12 | 11 | 12 | 4.5 | 0.0 | 0 | 1 | 3 | 0 | 0 | 1 | |
| Drayton Florence | BUF | 16 | 41 | 9 | 0.0 | 0.0 | 1 | 1 | 12 | 3 | 64 | 1 | |
| Brandon Flowers | KC | 16 | 47 | 12 | 0.0 | 2.0 | 0 | 0 | 20 | 4 | 95 | 1 | |
| Andre' Goodman | DEN | 16 | 41 | 8 | 0.0 | 1.5 | 0 | 2 | 10 | 2 | 46 | 1 | |
| Steve Gregory | SD | 15 | 54 | 11 | 0.0 | 0.0 | 0 | 0 | 3 | 1 | 26 | 1 | |
| Mario Haggan | DEN | 16 | 12 | 9 | 0.0 | 3.0 | 0 | 0 | 1 | 1 | 16 | 1 | |
| David Harris | NYJ | 16 | 65 | 21 | 5.0 | 3.0 | 0 | 0 | 9 | 4 | 55 | 1 | |
| Jarret Johnson | BAL | 16 | 40 | 16 | 2.5 | 5.0 | 1 | 1 | 3 | 0 | 0 | 1 | |
| Spencer Johnson | BUF | 16 | 30 | 17 | 2.0 | 3.5 | 1 | 1 | 1 | 0 | 0 | 1 | |
| Jacob Lacey | IND | 15 | 47 | 22 | 0.0 | 1.5 | 3 | 1 | 6 | 1 | 32 | 1 | |
| Kendrick Lewis | KC | 16 | 47 | 11 | 0.0 | 0.0 | 1 | 1 | 10 | 3 | 119 | 1 | |
| Brice McCain | HOU | 16 | 24 | 1 | 0.0 | 0.0 | 0 | 0 | 13 | 2 | 48 | 1 | |
| Jameel McClain | BAL | 16 | 48 | 34 | 1.0 | 2.5 | 0 | 2 | 5 | 1 | 8 | 1 | |
| Sterling Moore | NE | 6 | 6 | 1 | 0.0 | 0.0 | 0 | 0 | 2 | 2 | 26 | 1 | |
| Reggie Nelson | CIN | 16 | 57 | 25 | 2.0 | 1.0 | 2 | 0 | 12 | 4 | 115 | 1 | |
| Haloti Ngata | BAL | 16 | 36 | 28 | 5.0 | 3.0 | 2 | 3 | 5 | 0 | 0 | 1 | |
| Rob Ninkovich | NE | 16 | 42 | 31 | 6.5 | 3.0 | 1 | 3 | 4 | 2 | 30 | 1 | |
| Troy Polamalu | PIT | 16 | 64 | 27 | 1.0 | 7.5 | 0 | 1 | 14 | 2 | 33 | 1 |