| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Darrelle Revis | NYJ | 16 | 41 | 11 | 0.0 | 1.0 | 0 | 0 | 21 | 4 | 184 | 1 |
| 2 | Brandon Flowers | KC | 16 | 47 | 12 | 0.0 | 2.0 | 0 | 0 | 20 | 4 | 95 | 1 |
| Lardarius Webb | BAL | 16 | 54 | 13 | 1.0 | 1.0 | 1 | 2 | 20 | 5 | 81 | 1 | |
| 4 | Joe Haden | CLE | 15 | 53 | 12 | 1.0 | 1.0 | 1 | 1 | 19 | 0 | 0 | 0 |
| 5 | Cary Williams | BAL | 16 | 61 | 17 | 0.0 | 0.0 | 2 | 0 | 18 | 0 | 0 | 0 |
| 6 | Antoine Cason | SD | 16 | 46 | 7 | 0.0 | 0.0 | 0 | 0 | 17 | 2 | 69 | 0 |
| 7 | Brandon Carr | KC | 16 | 39 | 6 | 0.0 | 0.0 | 0 | 0 | 15 | 4 | 17 | 0 |
| Johnathan Joseph | HOU | 15 | 40 | 4 | 0.0 | 0.5 | 1 | 0 | 15 | 4 | 40 | 0 | |
| Stanford Routt | OAK | 16 | 42 | 7 | 0.0 | 0.0 | 0 | 0 | 15 | 4 | 7 | 0 | |
| 10 | Troy Polamalu | PIT | 16 | 64 | 27 | 1.0 | 7.5 | 0 | 1 | 14 | 2 | 33 | 1 |
| Ike Taylor | PIT | 16 | 33 | 9 | 0.0 | 0.5 | 0 | 0 | 14 | 2 | 29 | 0 | |
| 12 | Kyle Arrington | NE | 16 | 60 | 17 | 0.0 | 0.0 | 0 | 1 | 13 | 7 | 92 | 0 |
| Sheldon Brown | CLE | 16 | 38 | 10 | 0.0 | 0.0 | 1 | 1 | 13 | 2 | 0 | 0 | |
| William Gay | PIT | 16 | 49 | 12 | 0.0 | 1.0 | 0 | 1 | 13 | 2 | 12 | 0 | |
| Brice McCain | HOU | 16 | 24 | 1 | 0.0 | 0.0 | 0 | 0 | 13 | 2 | 48 | 1 | |
| Rolando McClain | OAK | 15 | 77 | 22 | 5.0 | 2.0 | 0 | 0 | 13 | 0 | 0 | 0 | |
| Jason McCourty | TEN | 15 | 85 | 20 | 1.0 | 0.0 | 1 | 1 | 13 | 2 | 52 | 0 | |
| Bernard Pollard | BAL | 16 | 55 | 20 | 2.0 | 0.0 | 3 | 1 | 13 | 1 | 0 | 0 | |
| 19 | Nate Clements | CIN | 15 | 49 | 6 | 1.0 | 2.5 | 2 | 2 | 12 | 2 | 5 | 0 |
| Antonio Cromartie | NYJ | 16 | 34 | 9 | 0.0 | 0.5 | 1 | 0 | 12 | 4 | 105 | 0 | |
| Drayton Florence | BUF | 16 | 41 | 9 | 0.0 | 0.0 | 1 | 1 | 12 | 3 | 64 | 1 | |
| Devin McCourty | NE | 14 | 63 | 22 | 0.0 | 4.5 | 0 | 0 | 12 | 2 | 38 | 0 | |
| Reggie Nelson | CIN | 16 | 57 | 25 | 2.0 | 1.0 | 2 | 0 | 12 | 4 | 115 | 1 | |
| Dimitri Patterson | CLE | 14 | 22 | 3 | 0.0 | 0.0 | 0 | 0 | 12 | 0 | 0 | 0 | |
| Eric Weddle | SD | 16 | 66 | 18 | 0.0 | 2.0 | 0 | 0 | 12 | 7 | 89 | 0 | |
| 26 | Jason Allen | HOU | 16 | 33 | 4 | 0.0 | 1.0 | 0 | 0 | 11 | 4 | 34 | 0 |