| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Kavell Conner | IND | 16 | 50 | 54 | 0.0 | 12.0 | 1 | 1 | 2 | 0 | 0 | 0 |
| 2 | Muhammad Wilkerson | NYJ | 16 | 35 | 14 | 3.0 | 9.0 | 1 | 0 | 2 | 0 | 0 | 0 |
| 3 | D'Qwell Jackson | CLE | 16 | 116 | 42 | 3.5 | 8.5 | 1 | 3 | 3 | 1 | 24 | 0 |
| Jabaal Sheard | CLE | 16 | 40 | 15 | 8.5 | 8.5 | 5 | 1 | 2 | 0 | 0 | 0 | |
| 5 | Pat Angerer | IND | 16 | 76 | 70 | 1.0 | 8.0 | 2 | 1 | 3 | 1 | 0 | 0 |
| Derrick Johnson | KC | 16 | 104 | 27 | 2.0 | 8.0 | 1 | 1 | 9 | 2 | 18 | 0 | |
| 7 | Karlos Dansby | MIA | 16 | 87 | 15 | 2.0 | 7.5 | 1 | 0 | 5 | 1 | 14 | 0 |
| Joe Mays | DEN | 16 | 63 | 11 | 0.0 | 7.5 | 0 | 0 | 2 | 0 | 0 | 0 | |
| Troy Polamalu | PIT | 16 | 64 | 27 | 1.0 | 7.5 | 0 | 1 | 14 | 2 | 33 | 1 | |
| Terrell Suggs | BAL | 16 | 50 | 20 | 14.0 | 7.5 | 7 | 0 | 6 | 2 | 9 | 0 | |
| Kamerion Wimbley | OAK | 16 | 52 | 11 | 7.0 | 7.5 | 0 | 0 | 3 | 1 | 73 | 0 | |
| 12 | Nick Barnett | BUF | 16 | 78 | 52 | 3.0 | 7.0 | 1 | 0 | 5 | 3 | 80 | 1 |
| J.J. Watt | HOU | 16 | 49 | 7 | 5.5 | 7.0 | 0 | 2 | 4 | 0 | 0 | 0 | |
| 14 | Kevin Burnett | MIA | 16 | 83 | 22 | 2.5 | 6.5 | 0 | 0 | 3 | 1 | 34 | 1 |
| Donald Butler | SD | 16 | 77 | 18 | 2.0 | 6.5 | 2 | 1 | 2 | 1 | 2 | 1 | |
| Colin McCarthy | TEN | 13 | 52 | 13 | 0.0 | 6.5 | 2 | 2 | 3 | 1 | 0 | 0 | |
| Von Miller | DEN | 15 | 50 | 14 | 11.5 | 6.5 | 2 | 0 | 4 | 0 | 0 | 0 | |
| Calvin Pace | NYJ | 16 | 53 | 19 | 4.5 | 6.5 | 3 | 1 | 2 | 1 | 8 | 0 | |
| Frostee Rucker | CIN | 16 | 32 | 12 | 4.0 | 6.5 | 0 | 0 | 2 | 0 | 0 | 0 | |
| 20 | Leger Douzable | JAC | 16 | 22 | 16 | 1.0 | 6.0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Justin Houston | KC | 16 | 43 | 8 | 5.5 | 6.0 | 1 | 1 | 4 | 0 | 0 | 0 | |
| Cory Redding | BAL | 15 | 29 | 14 | 4.5 | 6.0 | 0 | 1 | 2 | 0 | 0 | 0 |