| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Kyle Arrington | NE | 16 | 60 | 17 | 0.0 | 0.0 | 0 | 1 | 13 | 7 | 92 | 0 |
| Eric Weddle | SD | 16 | 66 | 18 | 0.0 | 2.0 | 0 | 0 | 12 | 7 | 89 | 0 | |
| 3 | Matt Giordano | OAK | 15 | 52 | 14 | 1.0 | 0.0 | 1 | 0 | 5 | 5 | 130 | 0 |
| Lardarius Webb | BAL | 16 | 54 | 13 | 1.0 | 1.0 | 1 | 2 | 20 | 5 | 81 | 1 | |
| 5 | Jason Allen | HOU | 16 | 33 | 4 | 0.0 | 1.0 | 0 | 0 | 11 | 4 | 34 | 0 |
| Brandon Carr | KC | 16 | 39 | 6 | 0.0 | 0.0 | 0 | 0 | 15 | 4 | 17 | 0 | |
| Antonio Cromartie | NYJ | 16 | 34 | 9 | 0.0 | 0.5 | 1 | 0 | 12 | 4 | 105 | 0 | |
| Vontae Davis | MIA | 12 | 39 | 4 | 1.0 | 0.0 | 0 | 0 | 8 | 4 | 60 | 0 | |
| Brandon Flowers | KC | 16 | 47 | 12 | 0.0 | 2.0 | 0 | 0 | 20 | 4 | 95 | 1 | |
| David Harris | NYJ | 16 | 65 | 21 | 5.0 | 3.0 | 0 | 0 | 9 | 4 | 55 | 1 | |
| Johnathan Joseph | HOU | 15 | 40 | 4 | 0.0 | 0.5 | 1 | 0 | 15 | 4 | 40 | 0 | |
| Reggie Nelson | CIN | 16 | 57 | 25 | 2.0 | 1.0 | 2 | 0 | 12 | 4 | 115 | 1 | |
| Darrelle Revis | NYJ | 16 | 41 | 11 | 0.0 | 1.0 | 0 | 0 | 21 | 4 | 184 | 1 | |
| Stanford Routt | OAK | 16 | 42 | 7 | 0.0 | 0.0 | 0 | 0 | 15 | 4 | 7 | 0 | |
| George Wilson | BUF | 13 | 76 | 28 | 0.0 | 1.5 | 2 | 1 | 6 | 4 | 26 | 0 | |
| 16 | Mike Adams | CLE | 16 | 41 | 20 | 0.0 | 0.5 | 1 | 1 | 6 | 3 | 33 | 0 |
| Nick Barnett | BUF | 16 | 78 | 52 | 3.0 | 7.0 | 1 | 0 | 5 | 3 | 80 | 1 | |
| Jairus Byrd | BUF | 16 | 75 | 23 | 1.0 | 2.5 | 3 | 1 | 8 | 3 | 88 | 1 | |
| Drayton Florence | BUF | 16 | 41 | 9 | 0.0 | 0.0 | 1 | 1 | 12 | 3 | 64 | 1 |