| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Name | Team | ERA | W | L | S | G | GS | IP | H | R | ER | BB | K | RATIO |
| 1 | Jamie Moyer | BAL | 4.25 | 269 | 209 | 0 | 696 | 638 | 4074.0 | 4231 | 2076 | 1926 | 1155 | 2441 | 1.32 |
| 2 | Andy Pettitte | NYY | 3.87 | 243 | 141 | 0 | 497 | 487 | 3110.0 | 3231 | 1482 | 1337 | 976 | 2303 | 1.35 |
| 3 | Livan Hernandez | MIL | 4.40 | 175 | 177 | 1 | 493 | 474 | 3152.0 | 3481 | 1655 | 1541 | 1058 | 1947 | 1.44 |
| 4 | Kevin Millwood | SEA | 4.10 | 166 | 146 | 0 | 437 | 429 | 2640.0 | 2681 | 1314 | 1203 | 820 | 2035 | 1.33 |
| 5 | Jeff Suppan | SD | 4.70 | 140 | 146 | 0 | 448 | 417 | 2542.0 | 2843 | 1451 | 1328 | 871 | 1390 | 1.46 |
| 6 | Tim Hudson | ATL | 3.42 | 186 | 100 | 0 | 388 | 387 | 2568.0 | 2395 | 1064 | 975 | 782 | 1743 | 1.24 |
| 7 | Mark Buehrle | FLA | 3.83 | 166 | 127 | 0 | 404 | 379 | 2568.0 | 2702 | 1213 | 1092 | 577 | 1440 | 1.28 |
| 8 | Barry Zito | SF | 3.93 | 150 | 129 | 0 | 382 | 376 | 2332.0 | 2088 | 1106 | 1018 | 970 | 1728 | 1.31 |
| 9 | Derek Lowe | CLE | 3.95 | 173 | 151 | 85 | 648 | 370 | 2599.0 | 2668 | 1274 | 1141 | 767 | 1689 | 1.32 |
| 10 | CC Sabathia | NYY | 3.52 | 185 | 99 | 0 | 369 | 369 | 2465.0 | 2275 | 1051 | 963 | 752 | 2119 | 1.23 |
| 11 | Bartolo Colon | OAK | 4.09 | 167 | 120 | 0 | 372 | 366 | 2330.0 | 2341 | 1159 | 1060 | 766 | 1797 | 1.33 |
| 12 | Roy Halladay | PHI | 3.25 | 192 | 97 | 1 | 389 | 363 | 2603.0 | 2505 | 1041 | 941 | 534 | 1990 | 1.17 |
| 13 | Randy Wolf | MIL | 4.13 | 129 | 112 | 0 | 360 | 356 | 2191.0 | 2131 | 1074 | 1005 | 789 | 1711 | 1.33 |
| 14 | Freddy Garcia | NYY | 4.13 | 146 | 97 | 0 | 341 | 331 | 2104.0 | 2085 | 1021 | 966 | 664 | 1506 | 1.31 |
| 15 | Jon Garland | CLE | 4.33 | 132 | 119 | 1 | 353 | 330 | 2083.0 | 2175 | 1104 | 1001 | 700 | 1124 | 1.38 |
| 16 | Chris Carpenter | STL | 3.76 | 144 | 92 | 0 | 347 | 329 | 2202.0 | 2189 | 1014 | 920 | 624 | 1685 | 1.28 |
| 17 | Roy Oswalt | TEX | 3.21 | 160 | 93 | 0 | 340 | 327 | 2160.0 | 2080 | 826 | 770 | 501 | 1765 | 1.19 |
| 18 | Ted Lilly | LAD | 4.13 | 130 | 111 | 0 | 351 | 326 | 1959.0 | 1800 | 958 | 900 | 651 | 1663 | 1.25 |
| 19 | A.J. Burnett | PIT | 4.07 | 129 | 113 | 0 | 326 | 321 | 2035.0 | 1852 | 1005 | 921 | 853 | 1853 | 1.33 |
| 20 | Kyle Lohse | STL | 4.55 | 108 | 108 | 0 | 337 | 313 | 1856.0 | 2035 | 1009 | 938 | 542 | 1149 | 1.39 |
| 21 | Ryan Dempster | CHC | 4.33 | 115 | 119 | 87 | 531 | 306 | 2123.0 | 2083 | 1103 | 1021 | 962 | 1831 | 1.43 |
| 22 | Bronson Arroyo | CIN | 4.28 | 115 | 110 | 1 | 341 | 305 | 1960.0 | 2012 | 1029 | 932 | 568 | 1286 | 1.32 |
| 23 | Carlos Zambrano | FLA | 3.62 | 129 | 86 | 0 | 333 | 296 | 1909.0 | 1652 | 842 | 768 | 865 | 1605 | 1.32 |
| 24 | John Lackey | BOS | 4.10 | 128 | 94 | 0 | 295 | 294 | 1876.0 | 1955 | 935 | 855 | 569 | 1465 | 1.35 |
| 25 | Josh Beckett | BOS | 3.85 | 129 | 88 | 0 | 291 | 288 | 1800.0 | 1650 | 831 | 770 | 540 | 1677 | 1.22 |
| 26 | Carl Pavano | MIN | 4.39 | 108 | 107 | 0 | 302 | 284 | 1788.0 | 1971 | 955 | 873 | 425 | 1091 | 1.34 |
| 27 | Jason Marquis | SD | 4.60 | 107 | 104 | 1 | 336 | 277 | 1729.0 | 1830 | 969 | 883 | 667 | 1006 | 1.44 |
| Johan Santana | NYM | 3.10 | 138 | 72 | 1 | 353 | 277 | 1992.0 | 1675 | 738 | 686 | 556 | 1961 | 1.12 | |
| 29 | Aaron Harang | LAD | 4.23 | 100 | 98 | 0 | 282 | 276 | 1703.0 | 1801 | 852 | 801 | 502 | 1399 | 1.35 |
| 30 | Dan Haren | LAA | 3.62 | 112 | 91 | 0 | 281 | 271 | 1793.0 | 1737 | 784 | 722 | 379 | 1525 | 1.18 |
| 31 | Brett Tomko | CIN | 4.65 | 100 | 103 | 2 | 397 | 266 | 1816.0 | 1898 | 1011 | 939 | 582 | 1209 | 1.37 |
| 32 | Jake Peavy | CWS | 3.43 | 115 | 84 | 0 | 265 | 264 | 1680.0 | 1454 | 673 | 640 | 522 | 1637 | 1.18 |
| 33 | Joel Pineiro | PHI | 4.41 | 104 | 93 | 2 | 335 | 263 | 1754.0 | 1878 | 912 | 859 | 487 | 1058 | 1.35 |
| 34 | Cliff Lee | PHI | 3.64 | 119 | 72 | 0 | 265 | 261 | 1719.0 | 1689 | 757 | 695 | 406 | 1400 | 1.22 |
| 35 | Brett Myers | HOU | 4.23 | 94 | 87 | 37 | 333 | 249 | 1646.0 | 1654 | 825 | 774 | 540 | 1342 | 1.33 |
| 36 | Miguel Batista | NYM | 4.47 | 102 | 113 | 41 | 644 | 247 | 1939.0 | 1998 | 1077 | 963 | 888 | 1239 | 1.49 |
| 37 | Jamey Wright | LAD | 4.92 | 88 | 123 | 1 | 551 | 246 | 1859.0 | 1991 | 1129 | 1017 | 913 | 1046 | 1.56 |
| 38 | Jake Westbrook | STL | 4.31 | 91 | 90 | 0 | 280 | 240 | 1543.0 | 1654 | 810 | 739 | 492 | 874 | 1.39 |
| 39 | Vicente Padilla | BOS | 4.31 | 105 | 90 | 6 | 356 | 237 | 1547.0 | 1582 | 810 | 741 | 542 | 1095 | 1.37 |
| 40 | Darren Oliver | TOR | 4.56 | 113 | 92 | 5 | 682 | 229 | 1834.0 | 1963 | 1012 | 930 | 697 | 1193 | 1.45 |
| 41 | Felix Hernandez | SEA | 3.26 | 89 | 72 | 0 | 219 | 219 | 1483.0 | 1367 | 603 | 537 | 454 | 1355 | 1.23 |
| 42 | Ervin Santana | LAA | 4.28 | 91 | 74 | 0 | 220 | 217 | 1386.0 | 1362 | 705 | 659 | 450 | 1095 | 1.31 |
| 43 | Matt Cain | SF | 3.28 | 78 | 74 | 0 | 217 | 216 | 1410.0 | 1168 | 550 | 514 | 490 | 1179 | 1.18 |
| 44 | Rodrigo Lopez | CHC | 4.83 | 81 | 89 | 0 | 257 | 215 | 1350.0 | 1506 | 789 | 724 | 416 | 865 | 1.42 |
| 45 | Ramon Ortiz | SF | 4.93 | 86 | 84 | 0 | 296 | 214 | 1423.0 | 1532 | 844 | 779 | 489 | 887 | 1.42 |
| Justin Verlander | DET | 3.46 | 114 | 61 | 0 | 214 | 214 | 1424.0 | 1242 | 592 | 548 | 437 | 1321 | 1.18 | |
| 47 | Joe Blanton | PHI | 4.37 | 79 | 68 | 0 | 221 | 212 | 1334.0 | 1434 | 689 | 648 | 356 | 886 | 1.34 |
| Zack Greinke | MIL | 3.75 | 84 | 75 | 1 | 253 | 212 | 1375.0 | 1374 | 622 | 573 | 346 | 1231 | 1.25 | |
| Wandy Rodriguez | HOU | 4.01 | 79 | 80 | 0 | 221 | 212 | 1271.0 | 1260 | 642 | 567 | 444 | 1065 | 1.34 | |
| 50 | Aaron Cook | BOS | 4.56 | 72 | 69 | 0 | 239 | 207 | 1315.0 | 1527 | 715 | 666 | 409 | 558 | 1.47 |
| 51 | Dontrelle Willis | BAL | 4.17 | 72 | 69 | 0 | 205 | 202 | 1221.0 | 1251 | 612 | 566 | 500 | 896 | 1.43 |
| 52 | Paul Maholm | CHC | 4.39 | 57 | 78 | 0 | 198 | 198 | 1215.0 | 1320 | 639 | 593 | 404 | 754 | 1.42 |
| James Shields | TB | 3.94 | 79 | 67 | 0 | 199 | 198 | 1319.0 | 1325 | 635 | 578 | 312 | 1113 | 1.24 | |
| 54 | Oliver Perez | SEA | 4.63 | 58 | 69 | 0 | 209 | 195 | 1115.0 | 1022 | 625 | 573 | 629 | 1130 | 1.48 |
| 55 | Cole Hamels | PHI | 3.38 | 84 | 57 | 0 | 195 | 194 | 1258.0 | 1117 | 502 | 473 | 314 | 1190 | 1.14 |
| 56 | Jered Weaver | LAA | 3.26 | 89 | 47 | 0 | 188 | 188 | 1198.0 | 1055 | 460 | 434 | 325 | 1029 | 1.15 |
| 57 | Dave Bush | PHI | 4.70 | 56 | 69 | 0 | 210 | 187 | 1141.0 | 1194 | 652 | 596 | 295 | 767 | 1.30 |
| 58 | Edwin Jackson | WAS | 4.36 | 63 | 64 | 0 | 216 | 186 | 1165.0 | 1220 | 609 | 564 | 464 | 864 | 1.45 |
| 59 | Bruce Chen | KC | 4.54 | 66 | 64 | 1 | 332 | 184 | 1247.0 | 1258 | 685 | 629 | 464 | 941 | 1.38 |
| 60 | Jeff Francis | COL | 4.83 | 61 | 67 | 0 | 184 | 183 | 1079.0 | 1222 | 605 | 579 | 330 | 700 | 1.44 |
| 61 | Erik Bedard | PIT | 3.73 | 60 | 57 | 0 | 182 | 179 | 1023.0 | 950 | 472 | 424 | 405 | 995 | 1.32 |
| 62 | Chad Billingsley | LAD | 3.71 | 74 | 58 | 0 | 207 | 178 | 1100.0 | 1039 | 496 | 454 | 472 | 983 | 1.37 |
| Kerry Wood | CHC | 3.67 | 86 | 75 | 63 | 446 | 178 | 1380.0 | 1083 | 599 | 563 | 666 | 1582 | 1.27 | |
| 64 | Jose Contreras | PHI | 4.55 | 78 | 67 | 9 | 292 | 175 | 1168.0 | 1169 | 655 | 590 | 421 | 884 | 1.36 |
| 65 | Joe Saunders | ARI | 4.11 | 73 | 57 | 0 | 174 | 174 | 1067.0 | 1132 | 540 | 487 | 336 | 603 | 1.38 |
| 66 | Chris Capuano | LAD | 4.25 | 65 | 66 | 0 | 195 | 170 | 1050.0 | 1059 | 538 | 496 | 345 | 887 | 1.34 |
| Scott Elarton | PHI | 5.29 | 56 | 61 | 3 | 232 | 170 | 1065.0 | 1107 | 675 | 626 | 418 | 698 | 1.43 | |
| Tim Lincecum | SF | 3.21 | 71 | 49 | 0 | 171 | 170 | 1111.0 | 925 | 427 | 396 | 424 | 1218 | 1.21 | |
| 69 | Jon Lester | BOS | 3.62 | 80 | 39 | 0 | 170 | 169 | 1052.0 | 975 | 444 | 423 | 389 | 969 | 1.30 |
| 70 | Zach Duke | HOU | 4.56 | 48 | 74 | 1 | 181 | 168 | 1041.0 | 1269 | 579 | 528 | 282 | 537 | 1.49 |
| 71 | Gavin Floyd | CWS | 4.55 | 63 | 62 | 0 | 179 | 167 | 1042.0 | 1041 | 573 | 527 | 339 | 810 | 1.32 |
| 72 | Jeremy Guthrie | COL | 4.33 | 50 | 71 | 0 | 189 | 165 | 1082.0 | 1098 | 563 | 521 | 327 | 658 | 1.32 |
| 73 | Matt Garza | CHC | 3.85 | 55 | 59 | 1 | 165 | 162 | 1000.0 | 948 | 475 | 428 | 341 | 841 | 1.29 |
| Ubaldo Jimenez | CLE | 3.83 | 67 | 54 | 0 | 163 | 162 | 998.0 | 869 | 463 | 425 | 447 | 893 | 1.32 | |
| Ricky Nolasco | FLA | 4.55 | 70 | 57 | 0 | 178 | 162 | 1006.0 | 1068 | 549 | 509 | 237 | 836 | 1.30 | |
| 76 | Scott Baker | MIN | 4.15 | 63 | 48 | 0 | 163 | 159 | 958.0 | 987 | 456 | 442 | 224 | 770 | 1.26 |
| John Danks | CWS | 4.12 | 57 | 60 | 0 | 159 | 159 | 971.0 | 954 | 472 | 445 | 323 | 744 | 1.32 | |
| 78 | Roberto Hernandez | CLE | 4.60 | 53 | 66 | 0 | 181 | 150 | 934.0 | 972 | 524 | 477 | 364 | 565 | 1.43 |
| 79 | Mike Pelfrey | NYM | 4.36 | 50 | 54 | 1 | 153 | 149 | 896.0 | 989 | 463 | 434 | 318 | 506 | 1.46 |
| 80 | Kevin Correia | PIT | 4.57 | 51 | 60 | 0 | 271 | 144 | 969.0 | 1021 | 520 | 492 | 357 | 650 | 1.42 |
| Kyle Davies | TOR | 5.59 | 43 | 65 | 0 | 151 | 144 | 768.0 | 876 | 512 | 477 | 367 | 545 | 1.62 | |
| 82 | Chris Young | NYM | 3.72 | 50 | 35 | 0 | 142 | 142 | 793.0 | 650 | 351 | 328 | 311 | 683 | 1.21 |
| 83 | Shaun Marcum | MIL | 3.73 | 55 | 35 | 1 | 166 | 141 | 875.0 | 794 | 381 | 363 | 267 | 714 | 1.21 |
| 84 | Adam Wainwright | STL | 3.11 | 71 | 42 | 3 | 196 | 133 | 959.0 | 887 | 361 | 331 | 275 | 804 | 1.21 |
| 85 | Clayton Kershaw | LAD | 2.86 | 52 | 31 | 0 | 133 | 131 | 818.0 | 640 | 279 | 260 | 303 | 840 | 1.15 |
| 86 | Johnny Cueto | CIN | 3.65 | 49 | 40 | 0 | 130 | 130 | 781.0 | 743 | 348 | 317 | 252 | 599 | 1.27 |
| 87 | Nick Blackburn | MIN | 4.71 | 43 | 50 | 0 | 137 | 129 | 774.0 | 933 | 454 | 405 | 197 | 372 | 1.46 |
| Yovani Gallardo | MIL | 3.72 | 59 | 39 | 0 | 132 | 129 | 794.0 | 727 | 355 | 328 | 311 | 811 | 1.31 | |
| Jason Hammel | BAL | 4.74 | 42 | 47 | 3 | 183 | 129 | 821.0 | 894 | 461 | 432 | 282 | 595 | 1.43 | |
| 90 | Hiroki Kuroda | NYY | 3.47 | 47 | 53 | 0 | 129 | 128 | 787.0 | 753 | 346 | 303 | 191 | 585 | 1.20 |
| John Lannan | WAS | 4.00 | 38 | 51 | 0 | 128 | 128 | 751.0 | 787 | 378 | 334 | 282 | 393 | 1.42 | |
| 92 | Josh Johnson | FLA | 3.10 | 52 | 28 | 0 | 137 | 127 | 809.0 | 738 | 301 | 279 | 270 | 737 | 1.25 |
| Scott Olsen | CWS | 4.85 | 37 | 49 | 0 | 130 | 127 | 723.0 | 778 | 446 | 390 | 291 | 528 | 1.48 | |
| Anibal Sanchez | FLA | 3.74 | 42 | 44 | 0 | 128 | 127 | 762.0 | 730 | 347 | 317 | 300 | 649 | 1.35 | |
| 95 | Jorge De La Rosa | COL | 4.90 | 54 | 49 | 0 | 188 | 126 | 769.0 | 771 | 449 | 419 | 381 | 682 | 1.50 |
| Jonathan Sanchez | KC | 4.33 | 39 | 49 | 0 | 182 | 126 | 744.0 | 645 | 384 | 358 | 404 | 761 | 1.41 | |
| 97 | Francisco Liriano | MIN | 4.33 | 48 | 49 | 1 | 150 | 124 | 747.0 | 698 | 380 | 359 | 307 | 744 | 1.35 |
| 98 | R.A. Dickey | NYM | 4.09 | 52 | 51 | 2 | 218 | 120 | 924.0 | 953 | 454 | 420 | 294 | 612 | 1.35 |
| Jair Jurrjens | ATL | 3.51 | 51 | 35 | 0 | 120 | 120 | 726.0 | 693 | 307 | 283 | 253 | 492 | 1.30 | |
| 100 | Chien-Ming Wang | WAS | 4.21 | 61 | 32 | 1 | 125 | 119 | 753.0 | 797 | 373 | 352 | 224 | 346 | 1.36 |
| 101 | Max Scherzer | DET | 4.07 | 42 | 39 | 0 | 124 | 115 | 695.0 | 685 | 352 | 314 | 239 | 698 | 1.33 |
| 102 | Jason Vargas | SEA | 4.55 | 35 | 46 | 0 | 133 | 113 | 714.0 | 726 | 384 | 361 | 227 | 453 | 1.33 |
| 103 | Colby Lewis | TEX | 4.73 | 44 | 43 | 0 | 150 | 112 | 714.0 | 715 | 398 | 375 | 257 | 604 | 1.36 |
| 104 | Trevor Cahill | ARI | 3.85 | 46 | 40 | 0 | 110 | 110 | 673.0 | 634 | 312 | 288 | 251 | 422 | 1.32 |
| Tom Gorzelanny | WAS | 4.53 | 42 | 44 | 2 | 168 | 110 | 696.0 | 708 | 370 | 350 | 301 | 534 | 1.45 | |
| Luke Hochevar | KC | 5.33 | 34 | 50 | 0 | 114 | 110 | 663.0 | 710 | 418 | 393 | 223 | 447 | 1.41 | |
| Chris Volstad | CHC | 4.78 | 32 | 45 | 0 | 111 | 110 | 625.0 | 670 | 356 | 332 | 219 | 402 | 1.42 | |
| 108 | Kyle Kendrick | PHI | 4.49 | 45 | 37 | 0 | 142 | 108 | 661.0 | 733 | 361 | 330 | 193 | 315 | 1.40 |
| Daisuke Matsuzaka | BOS | 4.30 | 49 | 32 | 0 | 109 | 108 | 639.0 | 582 | 315 | 305 | 306 | 583 | 1.39 | |
| Ricky Romero | TOR | 3.70 | 50 | 30 | 0 | 108 | 108 | 708.0 | 639 | 321 | 291 | 287 | 562 | 1.31 | |
| 111 | Edinson Volquez | SD | 4.58 | 36 | 36 | 0 | 109 | 105 | 584.0 | 550 | 318 | 297 | 318 | 555 | 1.49 |
| 112 | Gio Gonzalez | WAS | 3.75 | 47 | 35 | 0 | 109 | 103 | 620.0 | 546 | 282 | 258 | 298 | 612 | 1.36 |
| Rick Porcello | DET | 4.60 | 42 | 35 | 0 | 103 | 103 | 595.0 | 680 | 330 | 304 | 156 | 323 | 1.41 | |
| David Price | TB | 3.34 | 50 | 30 | 0 | 108 | 103 | 666.0 | 574 | 273 | 247 | 231 | 602 | 1.21 | |
| 115 | Justin Masterson | CLE | 3.91 | 32 | 44 | 0 | 160 | 101 | 706.0 | 686 | 343 | 307 | 272 | 558 | 1.36 |
| 116 | Clayton Richard | SD | 4.16 | 35 | 35 | 0 | 117 | 100 | 600.0 | 624 | 312 | 277 | 227 | 407 | 1.42 |
| 117 | LaTroy Hawkins | LAA | 4.44 | 64 | 86 | 88 | 839 | 98 | 1275.0 | 1408 | 679 | 629 | 419 | 845 | 1.43 |
| 118 | Brandon McCarthy | OAK | 3.97 | 35 | 36 | 0 | 147 | 93 | 621.0 | 609 | 300 | 274 | 186 | 426 | 1.28 |
| 119 | Homer Bailey | CIN | 4.79 | 30 | 28 | 0 | 92 | 92 | 521.0 | 551 | 297 | 277 | 196 | 398 | 1.43 |
| Tommy Hanson | ATL | 3.33 | 40 | 26 | 0 | 92 | 92 | 546.0 | 475 | 220 | 202 | 183 | 505 | 1.21 | |
| 121 | Ian Kennedy | ARI | 3.73 | 36 | 25 | 0 | 93 | 91 | 565.0 | 507 | 245 | 234 | 182 | 490 | 1.22 |
| Jeff Niemann | TB | 4.11 | 40 | 26 | 0 | 96 | 91 | 541.0 | 522 | 264 | 247 | 177 | 405 | 1.29 | |
| 123 | Clay Buchholz | BOS | 3.95 | 43 | 26 | 0 | 92 | 90 | 533.0 | 515 | 257 | 234 | 219 | 400 | 1.38 |
| Kevin Slowey | CLE | 4.67 | 39 | 29 | 0 | 100 | 90 | 532.0 | 606 | 287 | 276 | 84 | 395 | 1.30 | |
| 125 | Jerome Williams | LAA | 4.24 | 33 | 34 | 0 | 99 | 89 | 552.0 | 540 | 287 | 260 | 212 | 342 | 1.36 |
| 126 | Scott Feldman | TEX | 4.83 | 34 | 39 | 0 | 188 | 88 | 646.0 | 688 | 383 | 347 | 234 | 369 | 1.43 |
| Charlie Morton | PIT | 5.06 | 23 | 45 | 0 | 89 | 88 | 473.0 | 542 | 296 | 266 | 195 | 304 | 1.56 | |
| C.J. Wilson | LAA | 3.47 | 51 | 39 | 52 | 340 | 88 | 800.0 | 686 | 354 | 308 | 334 | 716 | 1.28 | |
| 129 | Armando Galarraga | BAL | 4.69 | 26 | 30 | 0 | 95 | 86 | 518.0 | 508 | 293 | 270 | 208 | 329 | 1.38 |
| J.A. Happ | HOU | 4.17 | 30 | 31 | 0 | 102 | 86 | 524.0 | 504 | 260 | 243 | 233 | 433 | 1.41 | |
| Mat Latos | CIN | 3.66 | 32 | 31 | 0 | 86 | 86 | 509.0 | 447 | 224 | 207 | 161 | 483 | 1.19 | |
| 132 | Phil Hughes | NYY | 4.53 | 43 | 29 | 3 | 134 | 85 | 522.0 | 506 | 274 | 263 | 177 | 447 | 1.31 |
| Randy Wells | CHC | 4.06 | 28 | 32 | 0 | 97 | 85 | 526.0 | 544 | 255 | 237 | 179 | 342 | 1.37 | |
| 134 | Brandon Morrow | TOR | 4.19 | 36 | 34 | 16 | 200 | 84 | 601.0 | 514 | 300 | 280 | 287 | 652 | 1.33 |
| 135 | Bud Norris | HOU | 4.40 | 26 | 28 | 0 | 82 | 81 | 468.0 | 463 | 257 | 229 | 200 | 469 | 1.42 |
| 136 | Andy Sonnanstine | CHC | 5.27 | 28 | 31 | 1 | 132 | 80 | 540.0 | 617 | 339 | 316 | 136 | 343 | 1.39 |
| 137 | Dallas Braden | OAK | 4.16 | 26 | 36 | 0 | 94 | 79 | 491.0 | 510 | 248 | 227 | 141 | 305 | 1.33 |
| Jeff Karstens | PIT | 4.53 | 21 | 37 | 0 | 122 | 79 | 513.0 | 562 | 286 | 258 | 140 | 269 | 1.37 | |
| 139 | Jonathon Niese | NYM | 4.28 | 27 | 26 | 0 | 79 | 78 | 452.0 | 492 | 245 | 215 | 152 | 394 | 1.42 |
| 140 | Doug Fister | DET | 3.43 | 21 | 35 | 0 | 79 | 77 | 494.0 | 491 | 207 | 188 | 94 | 312 | 1.18 |
| 141 | Matt Harrison | TEX | 4.29 | 39 | 22 | 2 | 108 | 76 | 503.0 | 534 | 260 | 240 | 172 | 303 | 1.40 |
| 142 | Chad Durbin | ATL | 5.05 | 41 | 46 | 4 | 399 | 75 | 788.0 | 845 | 482 | 442 | 342 | 536 | 1.51 |
| Chad Gaudin | FLA | 4.65 | 37 | 40 | 2 | 285 | 75 | 705.0 | 743 | 405 | 364 | 328 | 557 | 1.52 | |
| 144 | Derek Holland | TEX | 4.79 | 32 | 26 | 0 | 91 | 74 | 460.0 | 481 | 267 | 245 | 162 | 382 | 1.40 |
| Manny Parra | MIL | 5.10 | 24 | 31 | 0 | 137 | 74 | 487.0 | 555 | 308 | 276 | 240 | 453 | 1.63 | |
| Ryan Vogelsong | SF | 4.36 | 29 | 32 | 0 | 163 | 74 | 584.0 | 582 | 304 | 283 | 247 | 419 | 1.42 | |
| 147 | Jaime Garcia | STL | 3.46 | 30 | 20 | 0 | 81 | 72 | 440.0 | 450 | 208 | 169 | 141 | 347 | 1.34 |
| 148 | Rich Hill | BOS | 4.66 | 23 | 20 | 0 | 110 | 70 | 421.0 | 379 | 230 | 218 | 188 | 381 | 1.35 |
| Tim Stauffer | SD | 3.94 | 23 | 31 | 0 | 96 | 70 | 441.0 | 433 | 204 | 193 | 150 | 304 | 1.32 | |
| 150 | Tommy Hunter | BAL | 4.73 | 29 | 20 | 0 | 78 | 68 | 413.0 | 453 | 233 | 217 | 99 | 227 | 1.34 |
| Micah Owings | SD | 4.86 | 32 | 33 | 1 | 138 | 68 | 483.0 | 468 | 280 | 261 | 208 | 347 | 1.40 | |
| 152 | Jesse Litsch | TOR | 4.17 | 27 | 27 | 1 | 88 | 67 | 417.0 | 430 | 214 | 193 | 119 | 239 | 1.32 |
| 153 | Madison Bumgarner | SF | 3.06 | 28 | 23 | 0 | 69 | 66 | 421.0 | 412 | 160 | 143 | 94 | 365 | 1.20 |
| Brett Cecil | TOR | 4.64 | 27 | 22 | 0 | 67 | 66 | 394.0 | 418 | 216 | 203 | 135 | 278 | 1.40 | |
| Brian Matusz | BAL | 5.43 | 21 | 31 | 0 | 66 | 66 | 345.0 | 393 | 221 | 208 | 136 | 278 | 1.53 | |
| Andrew Miller | BOS | 5.66 | 22 | 29 | 0 | 114 | 66 | 374.0 | 422 | 263 | 235 | 221 | 305 | 1.72 | |
| 157 | Nelson Figueroa | TOR | 4.55 | 20 | 35 | 1 | 145 | 65 | 499.0 | 525 | 273 | 252 | 203 | 337 | 1.46 |
| Ross Ohlendorf | SD | 4.77 | 15 | 28 | 0 | 98 | 65 | 402.0 | 434 | 228 | 213 | 149 | 281 | 1.45 | |
| 159 | Wade Davis | TB | 4.07 | 26 | 22 | 0 | 87 | 64 | 420.0 | 414 | 200 | 190 | 150 | 287 | 1.34 |
| 160 | Chris Narveson | MIL | 4.68 | 26 | 18 | 0 | 95 | 63 | 394.0 | 393 | 213 | 205 | 149 | 326 | 1.38 |
| Jordan Zimmermann | WAS | 3.61 | 15 | 24 | 0 | 63 | 63 | 374.0 | 364 | 165 | 150 | 87 | 307 | 1.21 | |
| 162 | Brett Anderson | OAK | 3.66 | 21 | 23 | 0 | 62 | 62 | 371.0 | 378 | 175 | 151 | 92 | 286 | 1.27 |
| Jo-Jo Reyes | PIT | 6.06 | 12 | 26 | 0 | 70 | 62 | 334.0 | 402 | 249 | 225 | 146 | 215 | 1.64 | |
| 164 | Mike Leake | CIN | 4.17 | 22 | 18 | 0 | 66 | 61 | 380.0 | 400 | 195 | 176 | 108 | 262 | 1.34 |
| James McDonald | PIT | 3.63 | 24 | 23 | 0 | 109 | 61 | 402.0 | 373 | 176 | 162 | 166 | 349 | 1.34 | |
| Felipe Paulino | KC | 4.93 | 13 | 32 | 0 | 93 | 61 | 385.0 | 420 | 233 | 211 | 160 | 359 | 1.51 | |
| 167 | Dana Eveland | BAL | 5.38 | 19 | 24 | 1 | 110 | 60 | 385.0 | 451 | 239 | 230 | 191 | 251 | 1.67 |
| Dustin McGowan | TOR | 4.81 | 20 | 24 | 0 | 80 | 60 | 374.0 | 365 | 216 | 200 | 154 | 305 | 1.39 | |
| 169 | Brad Bergesen | BAL | 4.68 | 17 | 24 | 0 | 83 | 59 | 394.0 | 438 | 229 | 205 | 115 | 207 | 1.40 |
| Sean Marshall | CIN | 3.90 | 33 | 43 | 16 | 325 | 59 | 558.0 | 542 | 263 | 242 | 197 | 475 | 1.32 | |
| 171 | Jhoulys Chacin | COL | 3.78 | 20 | 29 | 0 | 73 | 58 | 367.0 | 319 | 177 | 154 | 174 | 323 | 1.34 |
| 172 | Daniel Hudson | ARI | 3.59 | 28 | 16 | 0 | 61 | 57 | 379.0 | 356 | 165 | 151 | 98 | 301 | 1.20 |
| 173 | Brian Burres | SF | 5.76 | 18 | 25 | 0 | 106 | 56 | 358.0 | 422 | 239 | 229 | 160 | 224 | 1.63 |
| 174 | Jake Arrieta | BAL | 5.16 | 19 | 23 | 0 | 55 | 55 | 307.0 | 315 | 187 | 176 | 132 | 224 | 1.46 |
| Joaquin Benoit | DET | 4.24 | 36 | 32 | 12 | 435 | 55 | 745.0 | 659 | 376 | 351 | 324 | 720 | 1.32 | |
| Chuck James | NYM | 4.53 | 24 | 19 | 0 | 72 | 55 | 326.0 | 317 | 169 | 164 | 132 | 242 | 1.38 | |
| 177 | Dustin Moseley | SD | 4.68 | 15 | 21 | 0 | 101 | 53 | 358.0 | 397 | 202 | 186 | 117 | 199 | 1.44 |
| Robinson Tejeda | CLE | 4.42 | 23 | 27 | 0 | 186 | 53 | 442.0 | 397 | 240 | 217 | 246 | 371 | 1.45 | |
| 179 | Jason Isringhausen | LAA | 3.57 | 50 | 53 | 300 | 701 | 52 | 988.0 | 874 | 433 | 392 | 430 | 816 | 1.32 |
| Wade LeBlanc | FLA | 4.55 | 17 | 22 | 0 | 54 | 52 | 293.0 | 305 | 149 | 148 | 113 | 205 | 1.43 | |
| 181 | Scott Downs | LAA | 3.46 | 33 | 31 | 23 | 466 | 50 | 648.0 | 625 | 281 | 249 | 228 | 497 | 1.32 |
| Brian Duensing | MIN | 3.90 | 25 | 21 | 0 | 139 | 50 | 411.0 | 427 | 193 | 178 | 127 | 268 | 1.35 | |
| 183 | Clay Hensley | SF | 3.92 | 27 | 32 | 8 | 242 | 49 | 493.0 | 445 | 237 | 215 | 228 | 353 | 1.37 |
| Aaron Laffey | TOR | 4.31 | 21 | 23 | 1 | 130 | 49 | 382.0 | 432 | 204 | 183 | 151 | 189 | 1.53 | |
| 185 | David Huff | CLE | 5.51 | 15 | 25 | 0 | 49 | 48 | 258.0 | 315 | 178 | 158 | 92 | 138 | 1.58 |
| Josh Tomlin | CLE | 4.51 | 21 | 15 | 0 | 49 | 48 | 301.0 | 303 | 155 | 151 | 55 | 170 | 1.19 | |
| 187 | Kameron Loe | MIL | 4.26 | 30 | 37 | 2 | 260 | 47 | 505.0 | 546 | 285 | 239 | 163 | 307 | 1.40 |
| Ivan Nova | NYY | 4.01 | 26 | 8 | 0 | 51 | 47 | 292.0 | 302 | 137 | 130 | 97 | 197 | 1.37 | |
| 189 | Dillon Gee | NYM | 4.12 | 20 | 13 | 0 | 49 | 46 | 284.0 | 262 | 142 | 130 | 111 | 214 | 1.31 |
| Jeremy Hellickson | TB | 3.15 | 21 | 13 | 0 | 52 | 46 | 303.0 | 253 | 114 | 106 | 110 | 202 | 1.20 | |
| 191 | Vin Mazzaro | KC | 5.15 | 14 | 20 | 0 | 54 | 44 | 264.0 | 311 | 171 | 151 | 115 | 163 | 1.61 |
| Garrett Olson | NYM | 6.15 | 14 | 22 | 1 | 103 | 44 | 287.0 | 333 | 201 | 196 | 142 | 193 | 1.66 | |
| Glen Perkins | MIN | 4.31 | 24 | 17 | 4 | 177 | 44 | 395.0 | 441 | 203 | 189 | 113 | 264 | 1.40 | |
| 194 | Matt Belisle | COL | 4.33 | 39 | 34 | 2 | 341 | 43 | 574.0 | 647 | 309 | 276 | 137 | 431 | 1.37 |
| Joba Chamberlain | NYY | 3.70 | 20 | 13 | 4 | 193 | 43 | 382.0 | 360 | 175 | 157 | 150 | 386 | 1.34 | |
| 196 | Jeremy Affeldt | SF | 4.08 | 35 | 36 | 26 | 579 | 42 | 764.0 | 755 | 392 | 346 | 336 | 603 | 1.43 |
| Travis Wood | CHC | 4.18 | 12 | 13 | 0 | 46 | 42 | 250.0 | 236 | 121 | 116 | 85 | 191 | 1.28 | |
| 198 | Rick Ankiel | WAS | 3.90 | 13 | 10 | 1 | 51 | 41 | 242.0 | 198 | 119 | 105 | 130 | 269 | 1.36 |
| Brandon Beachy | ATL | 3.08 | 12 | 10 | 0 | 41 | 41 | 237.0 | 190 | 95 | 81 | 82 | 252 | 1.15 | |
| Edgar Gonzalez | OAK | 5.90 | 14 | 25 | 0 | 107 | 41 | 325.0 | 396 | 221 | 213 | 114 | 208 | 1.57 | |
| 201 | Philip Humber | CWS | 4.58 | 14 | 14 | 0 | 66 | 40 | 281.0 | 279 | 147 | 143 | 96 | 214 | 1.33 |
| Wil Ledezma | LAD | 5.41 | 15 | 25 | 0 | 192 | 40 | 396.0 | 440 | 261 | 238 | 196 | 283 | 1.61 | |
| Dennys Reyes | BAL | 4.21 | 35 | 35 | 4 | 673 | 40 | 726.0 | 724 | 384 | 340 | 400 | 642 | 1.55 | |
| Carlos Villanueva | TOR | 4.22 | 28 | 28 | 6 | 285 | 40 | 565.0 | 535 | 274 | 265 | 204 | 485 | 1.31 | |
| 205 | Juan Cruz | PIT | 4.07 | 38 | 36 | 6 | 432 | 38 | 643.0 | 565 | 328 | 291 | 338 | 651 | 1.40 |
| Ross Detwiler | WAS | 3.88 | 10 | 17 | 0 | 54 | 38 | 234.0 | 238 | 119 | 101 | 88 | 148 | 1.39 | |
| Craig Stammen | WAS | 4.50 | 12 | 12 | 0 | 88 | 38 | 280.0 | 292 | 153 | 140 | 83 | 183 | 1.34 | |
| 208 | Justin Germano | BOS | 5.02 | 8 | 20 | 0 | 79 | 36 | 253.0 | 268 | 154 | 141 | 83 | 153 | 1.39 |
| Mike Minor | ATL | 5.25 | 11 | 10 | 0 | 37 | 36 | 199.0 | 223 | 120 | 116 | 71 | 186 | 1.48 | |
| Brian Tallet | PIT | 4.79 | 16 | 25 | 0 | 242 | 36 | 460.0 | 459 | 264 | 245 | 213 | 337 | 1.46 | |
| Chris Tillman | BAL | 5.60 | 7 | 15 | 0 | 36 | 36 | 180.0 | 205 | 118 | 112 | 80 | 116 | 1.58 | |
| 212 | Rick VandenHurk | CLE | 5.97 | 8 | 10 | 0 | 46 | 35 | 181.0 | 199 | 127 | 120 | 95 | 176 | 1.62 |
| 213 | Octavio Dotel | DET | 3.75 | 55 | 49 | 109 | 717 | 34 | 907.0 | 719 | 410 | 378 | 402 | 1106 | 1.24 |
| Sean O'Sullivan | KC | 6.16 | 10 | 14 | 0 | 43 | 34 | 193.0 | 228 | 139 | 132 | 73 | 91 | 1.56 | |
| Vance Worley | PHI | 2.84 | 15 | 8 | 0 | 41 | 34 | 212.0 | 186 | 75 | 67 | 73 | 192 | 1.22 | |
| 216 | Carlos Carrasco | CLE | 4.95 | 10 | 15 | 0 | 33 | 33 | 191.0 | 217 | 111 | 105 | 65 | 134 | 1.48 |
| Jeanmar Gomez | CLE | 4.72 | 13 | 14 | 0 | 35 | 33 | 183.0 | 215 | 110 | 96 | 62 | 97 | 1.51 | |
| J.P. Howell | TB | 4.69 | 21 | 23 | 21 | 236 | 33 | 372.0 | 351 | 213 | 194 | 173 | 351 | 1.41 | |
| 219 | Stephen Strasburg | WAS | 2.51 | 15 | 5 | 0 | 31 | 31 | 176.0 | 136 | 56 | 49 | 41 | 226 | 1.01 |
| 220 | Kyle Drabek | TOR | 5.34 | 8 | 15 | 0 | 34 | 30 | 167.0 | 172 | 104 | 99 | 107 | 110 | 1.67 |
| Alexi Ogando | TEX | 2.94 | 18 | 9 | 1 | 103 | 30 | 245.0 | 201 | 87 | 80 | 66 | 200 | 1.09 | |
| 222 | Josh Collmenter | ARI | 3.78 | 10 | 12 | 0 | 45 | 29 | 195.0 | 182 | 86 | 82 | 38 | 140 | 1.13 |
| Adam Loewen | NYM | 5.38 | 8 | 8 | 0 | 35 | 29 | 164.0 | 163 | 105 | 98 | 106 | 134 | 1.64 | |
| Joe Nathan | TEX | 2.82 | 48 | 25 | 277 | 611 | 29 | 759.0 | 557 | 258 | 238 | 278 | 797 | 1.10 | |
| Josh Outman | COL | 4.32 | 8 | 11 | 0 | 45 | 29 | 171.0 | 173 | 90 | 82 | 65 | 129 | 1.39 | |
| Scott Richmond | TOR | 5.26 | 9 | 14 | 0 | 33 | 29 | 166.0 | 179 | 102 | 97 | 61 | 137 | 1.45 | |
| Eric Stults | SD | 4.64 | 9 | 12 | 0 | 47 | 29 | 188.0 | 195 | 106 | 97 | 78 | 118 | 1.45 | |
| 228 | Zach Britton | BAL | 4.62 | 11 | 11 | 0 | 28 | 28 | 154.0 | 162 | 93 | 79 | 62 | 97 | 1.45 |
| Michael Pineda | NYY | 3.74 | 9 | 10 | 0 | 28 | 28 | 171.0 | 133 | 76 | 71 | 55 | 173 | 1.10 | |
| 230 | Blake Beavan | SEA | 4.92 | 8 | 12 | 0 | 27 | 27 | 159.0 | 183 | 87 | 87 | 26 | 72 | 1.31 |
| Buddy Carlyle | ATL | 5.58 | 11 | 12 | 0 | 112 | 27 | 253.0 | 267 | 168 | 157 | 101 | 198 | 1.45 | |
| David Hernandez | ARI | 4.32 | 17 | 22 | 15 | 168 | 27 | 281.0 | 261 | 141 | 135 | 130 | 262 | 1.39 | |
| Anthony Swarzak | MIN | 5.03 | 8 | 18 | 0 | 59 | 27 | 211.0 | 243 | 124 | 118 | 58 | 119 | 1.43 | |
| 234 | Danny Duffy | KC | 5.28 | 6 | 10 | 0 | 26 | 26 | 133.0 | 145 | 79 | 78 | 69 | 115 | 1.61 |
| Kyle Farnsworth | TB | 4.25 | 39 | 56 | 52 | 776 | 26 | 894.0 | 847 | 462 | 422 | 373 | 892 | 1.36 | |
| 236 | Tyler Chatwood | COL | 4.80 | 7 | 11 | 1 | 31 | 25 | 150.0 | 177 | 86 | 80 | 72 | 81 | 1.66 |
| Casey Coleman | CHC | 5.41 | 7 | 12 | 0 | 45 | 25 | 158.0 | 181 | 98 | 95 | 77 | 112 | 1.63 | |
| Aaron Heilman | SEA | 4.40 | 35 | 46 | 16 | 477 | 25 | 630.0 | 602 | 330 | 308 | 256 | 548 | 1.36 | |
| Cory Luebke | SD | 3.26 | 10 | 12 | 0 | 55 | 25 | 188.0 | 150 | 72 | 68 | 58 | 195 | 1.11 | |
| 240 | Henderson Alvarez | TOR | 4.00 | 4 | 9 | 0 | 24 | 24 | 153.0 | 167 | 73 | 68 | 28 | 67 | 1.27 |
| Jason Berken | BAL | 5.40 | 10 | 17 | 0 | 106 | 24 | 230.0 | 297 | 152 | 138 | 85 | 152 | 1.66 | |
| D.J. Carrasco | ATL | 4.51 | 24 | 21 | 2 | 290 | 24 | 493.0 | 526 | 269 | 247 | 199 | 315 | 1.47 | |
| Lance Cormier | TB | 5.08 | 24 | 28 | 3 | 290 | 24 | 468.0 | 537 | 286 | 264 | 227 | 276 | 1.63 | |
| Barry Enright | ARI | 4.90 | 7 | 11 | 0 | 24 | 24 | 136.0 | 147 | 74 | 74 | 44 | 70 | 1.40 | |
| Pat Misch | PHI | 4.82 | 4 | 15 | 0 | 78 | 24 | 200.0 | 227 | 114 | 107 | 57 | 116 | 1.42 | |
| Juan Nicasio | COL | 4.67 | 6 | 7 | 0 | 24 | 24 | 129.0 | 145 | 72 | 67 | 40 | 112 | 1.43 | |
| 247 | Matt Albers | BOS | 4.83 | 21 | 29 | 0 | 263 | 23 | 410.0 | 428 | 237 | 220 | 187 | 293 | 1.50 |
| Joe Beimel | TEX | 4.22 | 24 | 32 | 4 | 567 | 23 | 587.0 | 631 | 294 | 275 | 242 | 332 | 1.49 | |
| Jordan Lyles | HOU | 5.28 | 3 | 12 | 0 | 28 | 23 | 138.0 | 155 | 93 | 81 | 42 | 93 | 1.43 | |
| Luis Mendoza | KC | 6.43 | 8 | 12 | 1 | 50 | 23 | 154.0 | 194 | 128 | 110 | 66 | 78 | 1.69 | |
| Guillermo Moscoso | COL | 3.88 | 8 | 11 | 0 | 42 | 23 | 167.0 | 150 | 85 | 72 | 56 | 114 | 1.23 | |
| Marc Rzepczynski | STL | 4.18 | 9 | 17 | 0 | 130 | 23 | 211.0 | 201 | 106 | 98 | 94 | 196 | 1.40 | |
| 253 | Collin Balester | DET | 5.18 | 7 | 16 | 0 | 72 | 22 | 184.0 | 192 | 115 | 106 | 76 | 144 | 1.46 |
| Casey Janssen | TOR | 3.73 | 22 | 20 | 16 | 247 | 22 | 357.0 | 371 | 160 | 148 | 95 | 246 | 1.31 | |
| Esmil Rogers | CLE | 6.63 | 8 | 11 | 0 | 74 | 22 | 190.0 | 246 | 151 | 140 | 93 | 168 | 1.78 | |
| J.C. Romero | BAL | 4.15 | 34 | 28 | 7 | 675 | 22 | 657.0 | 617 | 331 | 303 | 374 | 525 | 1.51 | |
| Sean West | FLA | 5.06 | 8 | 8 | 0 | 22 | 22 | 112.0 | 130 | 71 | 63 | 48 | 78 | 1.59 | |
| 258 | Brad Lincoln | PIT | 5.22 | 6 | 9 | 0 | 40 | 21 | 138.0 | 159 | 86 | 80 | 43 | 90 | 1.46 |
| Brandon Lyon | HOU | 4.15 | 36 | 44 | 78 | 497 | 21 | 613.0 | 650 | 305 | 283 | 194 | 407 | 1.38 | |
| Mike O'Connor | NYY | 5.33 | 4 | 10 | 0 | 35 | 21 | 120.0 | 112 | 76 | 71 | 59 | 71 | 1.43 | |
| David Purcey | PHI | 5.40 | 6 | 12 | 1 | 87 | 21 | 180.0 | 180 | 113 | 108 | 101 | 151 | 1.56 | |
| 262 | Randall Delgado | ATL | 3.72 | 5 | 8 | 0 | 20 | 20 | 109.0 | 91 | 47 | 45 | 51 | 78 | 1.30 |
| Lucas Harrell | HOU | 4.78 | 7 | 8 | 0 | 32 | 20 | 130.0 | 146 | 85 | 69 | 56 | 79 | 1.55 | |
| Matt Palmer | SD | 4.57 | 13 | 7 | 0 | 63 | 20 | 185.0 | 181 | 101 | 94 | 94 | 98 | 1.49 | |
| David Pauley | TOR | 4.50 | 9 | 19 | 0 | 87 | 20 | 204.0 | 224 | 108 | 102 | 67 | 120 | 1.43 | |
| 266 | John Ely | LAD | 5.38 | 4 | 11 | 0 | 23 | 19 | 112.0 | 117 | 69 | 67 | 47 | 89 | 1.46 |
| Tommy Milone | OAK | 4.07 | 8 | 5 | 0 | 19 | 19 | 115.0 | 112 | 54 | 52 | 28 | 67 | 1.22 | |
| Jeff Samardzija | CHC | 4.39 | 17 | 15 | 1 | 142 | 19 | 252.0 | 239 | 140 | 123 | 130 | 226 | 1.46 | |
| Alfredo Simon | CIN | 4.78 | 8 | 13 | 17 | 95 | 19 | 211.0 | 236 | 126 | 112 | 74 | 160 | 1.47 | |
| Alex White | COL | 6.57 | 5 | 9 | 0 | 19 | 19 | 100.0 | 120 | 78 | 73 | 43 | 68 | 1.63 | |
| 271 | Enrique Gonzalez | DET | 5.82 | 4 | 8 | 0 | 55 | 18 | 150.0 | 160 | 102 | 97 | 63 | 84 | 1.49 |
| Ryan Madson | CIN | 3.59 | 47 | 30 | 52 | 491 | 18 | 630.0 | 624 | 268 | 251 | 191 | 547 | 1.29 | |
| Kris Medlen | ATL | 3.77 | 10 | 8 | 1 | 94 | 18 | 210.0 | 205 | 94 | 88 | 59 | 175 | 1.26 | |
| Wade Miley | ARI | 3.02 | 12 | 5 | 0 | 22 | 18 | 122.0 | 118 | 44 | 41 | 35 | 82 | 1.25 | |
| Tyson Ross | OAK | 4.99 | 6 | 13 | 1 | 45 | 18 | 128.0 | 139 | 72 | 71 | 58 | 85 | 1.54 | |
| 276 | Anthony Bass | SD | 3.61 | 4 | 7 | 0 | 43 | 17 | 132.0 | 121 | 60 | 53 | 54 | 96 | 1.33 |
| Felix Doubront | BOS | 4.50 | 10 | 5 | 3 | 37 | 17 | 114.0 | 118 | 65 | 57 | 46 | 114 | 1.44 | |
| Phil Dumatrait | MIN | 6.20 | 4 | 13 | 1 | 87 | 17 | 151.0 | 179 | 111 | 104 | 90 | 97 | 1.78 | |
| Kyle McClellan | STL | 3.69 | 19 | 23 | 6 | 261 | 17 | 378.0 | 352 | 166 | 155 | 135 | 257 | 1.29 | |
| 280 | Scott Diamond | MIN | 3.60 | 6 | 8 | 0 | 16 | 16 | 95.0 | 113 | 47 | 38 | 25 | 49 | 1.45 |
| Jason Grilli | PIT | 4.38 | 21 | 21 | 4 | 295 | 16 | 417.0 | 405 | 214 | 203 | 191 | 342 | 1.43 | |
| Lance Lynn | STL | 2.90 | 11 | 4 | 1 | 32 | 16 | 121.0 | 96 | 40 | 39 | 40 | 130 | 1.12 | |
| Franklin Morales | BOS | 4.41 | 8 | 13 | 10 | 161 | 16 | 208.0 | 193 | 108 | 102 | 105 | 174 | 1.43 | |
| Hector Noesi | SEA | 5.19 | 4 | 10 | 0 | 44 | 16 | 137.0 | 136 | 81 | 79 | 52 | 95 | 1.37 | |
| Greg Reynolds | TEX | 7.47 | 5 | 8 | 0 | 27 | 16 | 94.0 | 123 | 80 | 78 | 36 | 40 | 1.69 | |
| 286 | Mitchell Boggs | STL | 4.09 | 10 | 12 | 4 | 167 | 15 | 251.0 | 259 | 123 | 114 | 112 | 184 | 1.48 |
| Alex Cobb | TB | 3.60 | 6 | 5 | 0 | 15 | 15 | 90.0 | 81 | 39 | 36 | 33 | 69 | 1.27 | |
| Phil Coke | DET | 4.00 | 16 | 20 | 6 | 239 | 15 | 279.0 | 274 | 143 | 124 | 96 | 214 | 1.33 | |
| Marco Estrada | MIL | 4.95 | 4 | 12 | 0 | 76 | 15 | 160.0 | 153 | 96 | 88 | 51 | 154 | 1.28 | |
| Chris Jakubauskas | ARI | 5.58 | 8 | 10 | 0 | 69 | 15 | 166.0 | 186 | 108 | 103 | 56 | 99 | 1.46 | |
| Daniel McCutchen | PIT | 4.69 | 8 | 10 | 0 | 107 | 15 | 188.0 | 208 | 103 | 98 | 72 | 104 | 1.49 | |
| Matt Moore | TB | 4.00 | 5 | 5 | 0 | 17 | 15 | 90.0 | 80 | 47 | 40 | 43 | 100 | 1.37 | |
| 293 | Yu Darvish | TEX | 3.48 | 9 | 4 | 0 | 14 | 14 | 88.0 | 78 | 38 | 34 | 49 | 96 | 1.44 |
| Kevin Hart | PIT | 5.29 | 6 | 11 | 0 | 47 | 14 | 119.0 | 143 | 80 | 70 | 66 | 88 | 1.76 | |
| Hong-Chih Kuo | SEA | 3.73 | 13 | 17 | 13 | 218 | 14 | 292.0 | 228 | 128 | 121 | 127 | 345 | 1.22 | |
| Alex Sanabia | FLA | 3.69 | 5 | 3 | 0 | 18 | 14 | 83.0 | 87 | 36 | 34 | 19 | 55 | 1.28 | |
| 297 | Travis Blackley | OAK | 6.45 | 2 | 5 | 0 | 20 | 13 | 74.0 | 80 | 58 | 53 | 37 | 46 | 1.58 |
| Sean Burnett | WAS | 3.60 | 14 | 21 | 10 | 314 | 13 | 330.0 | 301 | 137 | 132 | 137 | 235 | 1.33 | |
| Wei-Yin Chen | BAL | 3.38 | 7 | 2 | 0 | 13 | 13 | 80.0 | 79 | 34 | 30 | 25 | 57 | 1.30 | |
| Shane Loux | SF | 5.82 | 3 | 7 | 0 | 48 | 13 | 133.0 | 172 | 94 | 86 | 38 | 44 | 1.58 | |
| Carlos Marmol | CHC | 3.46 | 19 | 27 | 99 | 415 | 13 | 479.0 | 304 | 194 | 184 | 323 | 621 | 1.31 | |
| Clayton Mortensen | BOS | 4.75 | 4 | 8 | 0 | 29 | 13 | 106.0 | 112 | 70 | 56 | 39 | 62 | 1.42 | |
| Chris Sale | CWS | 2.42 | 12 | 5 | 12 | 93 | 13 | 182.0 | 129 | 50 | 49 | 60 | 200 | 1.04 | |
| 304 | Charlie Furbush | SEA | 4.66 | 7 | 11 | 0 | 54 | 12 | 114.0 | 110 | 66 | 59 | 35 | 104 | 1.27 |
| Brad Hand | FLA | 4.20 | 1 | 8 | 0 | 12 | 12 | 60.0 | 53 | 32 | 28 | 35 | 38 | 1.47 | |
| Jarrod Parker | OAK | 2.50 | 3 | 3 | 0 | 12 | 12 | 72.0 | 54 | 20 | 20 | 33 | 50 | 1.21 | |
| Drew Smyly | DET | 4.00 | 2 | 2 | 0 | 12 | 12 | 63.0 | 63 | 30 | 28 | 18 | 58 | 1.29 | |
| Hisanori Takahashi | LAA | 3.64 | 14 | 11 | 10 | 138 | 12 | 215.0 | 197 | 93 | 87 | 74 | 187 | 1.26 | |
| Koji Uehara | TEX | 3.02 | 5 | 9 | 13 | 140 | 12 | 197.0 | 159 | 70 | 66 | 28 | 210 | 0.95 | |
| 310 | Trevor Bell | LAA | 5.24 | 4 | 8 | 0 | 52 | 11 | 115.0 | 156 | 74 | 67 | 42 | 76 | 1.72 |
| Nathan Eovaldi | LAD | 3.05 | 1 | 5 | 0 | 15 | 11 | 65.0 | 56 | 23 | 22 | 32 | 43 | 1.35 | |
| Joel Hanrahan | PIT | 3.81 | 20 | 15 | 78 | 318 | 11 | 364.0 | 334 | 167 | 154 | 169 | 402 | 1.38 | |
| Drew Hutchison | TOR | 4.66 | 5 | 3 | 0 | 11 | 11 | 58.0 | 59 | 31 | 30 | 20 | 49 | 1.36 | |
| Matt Maloney | MIN | 5.74 | 5 | 9 | 0 | 31 | 11 | 91.0 | 116 | 60 | 58 | 18 | 59 | 1.47 | |
| Jon Rauch | NYM | 3.84 | 42 | 37 | 59 | 500 | 11 | 548.0 | 518 | 250 | 234 | 165 | 436 | 1.25 | |
| Zach Stewart | CWS | 5.32 | 3 | 7 | 0 | 30 | 11 | 93.0 | 119 | 61 | 55 | 22 | 60 | 1.52 | |
| P.J. Walters | MIN | 6.52 | 4 | 2 | 0 | 27 | 11 | 87.0 | 98 | 65 | 63 | 36 | 63 | 1.54 | |
| 318 | Burke Badenhop | TB | 4.18 | 14 | 16 | 2 | 183 | 10 | 282.0 | 285 | 139 | 131 | 95 | 216 | 1.35 |
| Daniel Bard | BOS | 3.39 | 10 | 19 | 5 | 203 | 10 | 252.0 | 184 | 104 | 95 | 113 | 247 | 1.18 | |
| Rubby De La Rosa | LAD | 3.75 | 4 | 5 | 0 | 13 | 10 | 60.0 | 54 | 26 | 25 | 31 | 60 | 1.42 | |
| Liam Hendriks | MIN | 6.88 | 0 | 6 | 0 | 10 | 10 | 51.0 | 75 | 45 | 39 | 11 | 33 | 1.69 | |
| Sam LeCure | CIN | 3.92 | 6 | 8 | 0 | 77 | 10 | 154.0 | 131 | 68 | 67 | 58 | 138 | 1.23 | |
| Yunesky Maya | WAS | 5.59 | 1 | 4 | 0 | 15 | 10 | 58.0 | 70 | 37 | 36 | 21 | 27 | 1.57 | |
| Mariano Rivera | NYY | 2.21 | 76 | 58 | 608 | 1051 | 10 | 1219.0 | 940 | 324 | 300 | 277 | 1119 | 1.00 | |
| Henry Sosa | HOU | 5.26 | 3 | 5 | 0 | 10 | 10 | 53.0 | 54 | 31 | 31 | 23 | 38 | 1.45 | |
| 326 | Alfredo Aceves | BOS | 3.14 | 24 | 7 | 22 | 148 | 9 | 275.0 | 219 | 104 | 96 | 85 | 206 | 1.11 |
| Christian Friedrich | COL | 5.65 | 4 | 4 | 0 | 9 | 9 | 51.0 | 63 | 35 | 32 | 19 | 49 | 1.61 | |
| Brad Mills | LAA | 8.63 | 2 | 3 | 0 | 14 | 9 | 48.0 | 57 | 46 | 46 | 31 | 45 | 1.83 | |
| Drew Pomeranz | COL | 5.05 | 2 | 3 | 0 | 9 | 9 | 41.0 | 44 | 24 | 23 | 20 | 33 | 1.56 | |
| Aneury Rodriguez | HOU | 5.14 | 1 | 6 | 0 | 44 | 9 | 91.0 | 85 | 59 | 52 | 34 | 70 | 1.31 | |
| Dan Wheeler | CLE | 3.98 | 25 | 43 | 43 | 589 | 9 | 640.0 | 589 | 298 | 283 | 194 | 555 | 1.22 | |
| 332 | Tyler Clippard | WAS | 2.86 | 23 | 14 | 12 | 231 | 8 | 308.0 | 209 | 103 | 98 | 137 | 347 | 1.12 |
| Roman Colon | KC | 5.20 | 8 | 10 | 1 | 124 | 8 | 187.0 | 213 | 112 | 108 | 70 | 120 | 1.51 | |
| Graham Godfrey | OAK | 5.09 | 1 | 6 | 0 | 10 | 8 | 46.0 | 58 | 32 | 26 | 15 | 23 | 1.59 | |
| Kevin Gregg | BAL | 4.10 | 27 | 38 | 144 | 486 | 8 | 613.0 | 566 | 301 | 279 | 272 | 565 | 1.37 | |
| Blake Hawksworth | LAD | 4.08 | 10 | 13 | 0 | 124 | 8 | 183.0 | 187 | 95 | 83 | 67 | 124 | 1.39 | |
| Zach McAllister | CLE | 4.93 | 1 | 2 | 0 | 8 | 8 | 42.0 | 51 | 30 | 23 | 13 | 36 | 1.52 | |
| Bobby Parnell | NYM | 4.19 | 9 | 16 | 7 | 210 | 8 | 217.0 | 238 | 115 | 101 | 91 | 204 | 1.52 | |
| Rafael Soriano | NYY | 2.80 | 15 | 23 | 103 | 411 | 8 | 459.0 | 336 | 150 | 143 | 146 | 480 | 1.05 | |
| Kyle Weiland | HOU | 7.29 | 0 | 6 | 0 | 10 | 8 | 42.0 | 53 | 35 | 34 | 19 | 26 | 1.71 | |
| 341 | Neftali Feliz | TEX | 2.68 | 10 | 7 | 74 | 162 | 7 | 205.0 | 126 | 64 | 61 | 79 | 201 | 1.00 |
| Andy Oliver | DET | 7.26 | 0 | 5 | 0 | 7 | 7 | 31.0 | 37 | 29 | 25 | 21 | 23 | 1.87 | |
| Anthony Vasquez | SEA | 9.00 | 1 | 6 | 0 | 7 | 7 | 29.0 | 46 | 35 | 29 | 10 | 13 | 1.93 | |
| 344 | Scott Linebrink | STL | 3.51 | 42 | 31 | 8 | 607 | 6 | 656.0 | 630 | 280 | 256 | 229 | 567 | 1.31 |
| Jeff Manship | MIN | 6.16 | 3 | 2 | 0 | 36 | 6 | 73.0 | 91 | 54 | 50 | 28 | 49 | 1.63 | |
| Joe Martinez | ARI | 6.30 | 3 | 3 | 0 | 19 | 6 | 50.0 | 74 | 39 | 35 | 21 | 29 | 1.90 | |
| Juan Carlos Oviedo | FLA | 4.34 | 18 | 20 | 92 | 317 | 6 | 357.0 | 355 | 182 | 172 | 117 | 288 | 1.32 | |
| Garrett Richards | LAA | 2.83 | 2 | 2 | 0 | 11 | 6 | 35.0 | 29 | 14 | 11 | 18 | 26 | 1.34 | |
| Chris Schwinden | CLE | 7.14 | 0 | 3 | 0 | 7 | 6 | 29.0 | 38 | 26 | 23 | 9 | 18 | 1.62 | |
| Eric Surkamp | SF | 5.88 | 2 | 2 | 0 | 6 | 6 | 26.0 | 32 | 18 | 17 | 17 | 13 | 1.88 | |
| Carlos Torres | COL | 6.56 | 1 | 3 | 0 | 17 | 6 | 48.0 | 58 | 36 | 35 | 31 | 39 | 1.85 | |
| Ryan Tucker | LAD | 8.14 | 2 | 3 | 0 | 18 | 6 | 42.0 | 52 | 39 | 38 | 27 | 32 | 1.88 | |
| 353 | Nate Adcock | KC | 4.19 | 1 | 4 | 1 | 33 | 5 | 86.0 | 94 | 44 | 40 | 36 | 49 | 1.51 |
| Antonio Bastardo | PHI | 3.61 | 12 | 5 | 8 | 122 | 5 | 122.0 | 88 | 50 | 49 | 55 | 147 | 1.17 | |
| Patrick Corbin | ARI | 5.33 | 2 | 3 | 0 | 5 | 5 | 27.0 | 32 | 16 | 16 | 9 | 18 | 1.52 | |
| Eric Hurley | LAA | 5.63 | 1 | 2 | 0 | 5 | 5 | 24.0 | 26 | 15 | 15 | 9 | 13 | 1.46 | |
| Trever Miller | CHC | 4.18 | 18 | 17 | 11 | 694 | 5 | 523.0 | 521 | 264 | 243 | 237 | 434 | 1.45 | |
| Jose Quintana | CWS | 1.54 | 2 | 1 | 0 | 7 | 5 | 35.0 | 30 | 6 | 6 | 6 | 20 | 1.03 | |
| Chad Reineke | CIN | 5.90 | 2 | 2 | 0 | 7 | 5 | 29.0 | 26 | 20 | 19 | 18 | 17 | 1.52 | |
| James Russell | CHC | 4.07 | 4 | 7 | 1 | 156 | 5 | 148.0 | 162 | 85 | 67 | 39 | 111 | 1.36 | |
| Joe Wieland | SD | 4.67 | 0 | 4 | 0 | 5 | 5 | 27.0 | 26 | 16 | 14 | 9 | 24 | 1.30 | |
| 362 | Dylan Axelrod | CWS | 3.12 | 1 | 1 | 0 | 7 | 4 | 26.0 | 27 | 9 | 9 | 12 | 25 | 1.50 |
| Michael Fiers | MIL | 3.21 | 2 | 2 | 0 | 7 | 4 | 28.0 | 29 | 10 | 10 | 7 | 26 | 1.29 | |
| Jeff Locke | PIT | 6.75 | 0 | 3 | 0 | 4 | 4 | 16.0 | 21 | 12 | 12 | 10 | 5 | 1.94 | |
| Edward Mujica | FLA | 4.12 | 17 | 18 | 4 | 277 | 4 | 341.0 | 342 | 167 | 156 | 59 | 273 | 1.18 | |
| Luis Perez | TOR | 4.50 | 5 | 4 | 0 | 66 | 4 | 100.0 | 106 | 53 | 50 | 42 | 87 | 1.48 | |
| Junichi Tazawa | BOS | 6.09 | 2 | 3 | 1 | 14 | 4 | 34.0 | 51 | 25 | 23 | 10 | 21 | 1.79 | |
| Everett Teaford | KC | 3.76 | 2 | 2 | 1 | 29 | 4 | 55.0 | 47 | 24 | 23 | 21 | 32 | 1.24 | |
| Julio Teheran | ATL | 5.63 | 1 | 1 | 0 | 6 | 4 | 24.0 | 25 | 15 | 15 | 9 | 15 | 1.42 | |
| Jacob Turner | DET | 6.88 | 0 | 1 | 0 | 4 | 4 | 17.0 | 21 | 14 | 13 | 9 | 11 | 1.76 | |
| Wesley Wright | HOU | 4.85 | 8 | 10 | 1 | 192 | 4 | 167.0 | 162 | 100 | 90 | 85 | 165 | 1.48 | |
| 372 | Mitch Atkins | WAS | 6.95 | 0 | 0 | 0 | 10 | 3 | 22.0 | 34 | 18 | 17 | 9 | 17 | 1.95 |
| Casey Crosby | DET | 9.75 | 1 | 1 | 0 | 3 | 3 | 12.0 | 15 | 13 | 13 | 11 | 9 | 2.17 | |
| Cole De Vries | MIN | 4.20 | 1 | 1 | 0 | 3 | 3 | 15.0 | 14 | 11 | 7 | 6 | 9 | 1.33 | |
| Matt Guerrier | LAD | 3.45 | 23 | 29 | 6 | 470 | 3 | 545.0 | 502 | 225 | 209 | 177 | 364 | 1.25 | |
| Juan Gutierrez | KC | 4.80 | 5 | 10 | 24 | 150 | 3 | 167.0 | 169 | 96 | 89 | 68 | 152 | 1.42 | |
| Jeremy Hefner | NYM | 6.00 | 1 | 3 | 0 | 6 | 3 | 24.0 | 32 | 17 | 16 | 2 | 15 | 1.42 | |
| Cesar Jimenez | SEA | 5.44 | 1 | 2 | 0 | 43 | 3 | 48.0 | 51 | 29 | 29 | 20 | 36 | 1.48 | |
| Joe Kelly | STL | 3.60 | 1 | 0 | 0 | 3 | 3 | 15.0 | 23 | 7 | 6 | 2 | 8 | 1.67 | |
| Mike MacDougal | CHC | 4.00 | 18 | 23 | 71 | 407 | 3 | 394.0 | 397 | 204 | 175 | 212 | 325 | 1.55 | |
| Jenrry Mejia | NYM | 4.62 | 0 | 4 | 0 | 33 | 3 | 39.0 | 46 | 21 | 20 | 20 | 22 | 1.69 | |
| Adam Ottavino | COL | 6.00 | 1 | 2 | 0 | 24 | 3 | 42.0 | 55 | 28 | 28 | 16 | 36 | 1.69 | |
| Jonathan Papelbon | PHI | 2.32 | 24 | 21 | 236 | 424 | 3 | 457.0 | 343 | 133 | 118 | 121 | 542 | 1.02 | |
| Will Smith | KC | 9.00 | 1 | 2 | 0 | 3 | 3 | 14.0 | 18 | 14 | 14 | 5 | 9 | 1.64 | |
| Daryl Thompson | MIN | 8.47 | 0 | 3 | 0 | 4 | 3 | 17.0 | 26 | 16 | 16 | 12 | 6 | 2.24 | |
| Adam Wilk | DET | 6.75 | 0 | 3 | 0 | 8 | 3 | 24.0 | 35 | 21 | 18 | 6 | 17 | 1.71 | |
| 387 | Alberto Arias | HOU | 3.77 | 4 | 2 | 0 | 63 | 2 | 74.0 | 80 | 35 | 31 | 34 | 55 | 1.54 |
| Bryan Augenstein | TB | 8.59 | 0 | 2 | 0 | 12 | 2 | 22.0 | 34 | 23 | 21 | 9 | 12 | 1.95 | |
| Duane Below | DET | 3.36 | 2 | 3 | 0 | 34 | 2 | 59.0 | 51 | 24 | 22 | 14 | 34 | 1.10 | |
| Michael Bowden | CHC | 5.87 | 2 | 2 | 0 | 49 | 2 | 69.0 | 85 | 45 | 45 | 28 | 56 | 1.64 | |
| Joel Carreno | TOR | 4.03 | 1 | 2 | 0 | 16 | 2 | 29.0 | 27 | 13 | 13 | 14 | 22 | 1.41 | |
| Andrew Cashner | SD | 4.16 | 5 | 9 | 0 | 88 | 2 | 93.0 | 83 | 46 | 43 | 52 | 92 | 1.45 | |
| Willie Eyre | BAL | 4.97 | 7 | 8 | 1 | 111 | 2 | 163.0 | 183 | 94 | 90 | 65 | 86 | 1.52 | |
| Wilton Lopez | HOU | 3.38 | 10 | 10 | 1 | 181 | 2 | 189.0 | 197 | 79 | 71 | 35 | 141 | 1.23 | |
| Nick Masset | CIN | 3.78 | 16 | 14 | 4 | 308 | 2 | 333.0 | 326 | 152 | 140 | 142 | 285 | 1.41 | |
| Troy Patton | BAL | 3.28 | 3 | 3 | 0 | 51 | 2 | 74.0 | 62 | 28 | 27 | 16 | 59 | 1.05 | |
| Brad Peacock | OAK | 0.75 | 2 | 0 | 0 | 3 | 2 | 12.0 | 7 | 1 | 1 | 6 | 4 | 1.08 | |
| David Phelps | NYY | 3.00 | 1 | 2 | 0 | 13 | 2 | 33.0 | 31 | 12 | 11 | 13 | 29 | 1.33 | |
| Erasmo Ramirez | SEA | 5.40 | 0 | 1 | 0 | 9 | 2 | 20.0 | 24 | 14 | 12 | 6 | 13 | 1.50 | |
| Cesar Ramos | TB | 4.18 | 1 | 3 | 0 | 87 | 2 | 84.0 | 85 | 42 | 39 | 39 | 65 | 1.48 | |
| Mark Rogers | MIL | 1.80 | 0 | 0 | 0 | 4 | 2 | 10.0 | 2 | 2 | 2 | 3 | 11 | 0.50 | |
| Brian Sanches | PHI | 3.72 | 13 | 7 | 0 | 192 | 2 | 232.0 | 206 | 110 | 96 | 121 | 202 | 1.41 | |
| 403 | Chris Archer | TB | 1.50 | 0 | 1 | 0 | 1 | 1 | 6.0 | 3 | 3 | 1 | 1 | 7 | 0.67 |
| Scott Atchison | BOS | 3.54 | 7 | 6 | 1 | 142 | 1 | 196.0 | 184 | 84 | 77 | 57 | 157 | 1.23 | |
| Grant Balfour | OAK | 3.49 | 25 | 13 | 17 | 357 | 1 | 371.0 | 288 | 148 | 144 | 166 | 399 | 1.22 | |
| Dellin Betances | NYY | 9.00 | 0 | 0 | 0 | 2 | 1 | 2.0 | 1 | 2 | 2 | 6 | 2 | 3.50 | |
| Brian Bruney | CWS | 4.71 | 18 | 12 | 13 | 272 | 1 | 258.0 | 235 | 142 | 135 | 185 | 250 | 1.63 | |
| Andrew Carpenter | TOR | 8.63 | 1 | 1 | 0 | 17 | 1 | 24.0 | 36 | 23 | 23 | 12 | 24 | 2.00 | |
| Jesse Chavez | TOR | 5.51 | 6 | 10 | 0 | 145 | 1 | 160.0 | 177 | 104 | 98 | 63 | 127 | 1.50 | |
| Frankie De La Cruz | CHC | 8.16 | 0 | 0 | 0 | 26 | 1 | 32.0 | 37 | 34 | 29 | 26 | 20 | 1.97 | |
| Brandon Dickson | STL | 2.70 | 0 | 0 | 0 | 6 | 1 | 10.0 | 12 | 4 | 3 | 3 | 8 | 1.50 | |
| Justin Grimm | TEX | 4.50 | 1 | 0 | 0 | 1 | 1 | 6.0 | 6 | 3 | 3 | 0 | 7 | 1.00 | |
| Eric Hacker | SF | 3.21 | 0 | 1 | 0 | 6 | 1 | 14.0 | 16 | 6 | 5 | 8 | 10 | 1.71 | |
| Dusty Hughes | ATL | 4.99 | 2 | 5 | 0 | 80 | 1 | 83.0 | 91 | 51 | 46 | 40 | 60 | 1.58 | |
| Alan Johnson | COL | 9.00 | 0 | 0 | 0 | 1 | 1 | 4.0 | 6 | 5 | 4 | 3 | 3 | 2.25 | |
| Jim Johnson | BAL | 3.09 | 14 | 17 | 42 | 245 | 1 | 291.0 | 265 | 105 | 100 | 87 | 186 | 1.21 | |
| Dallas Keuchel | HOU | 1.80 | 0 | 0 | 0 | 1 | 1 | 5.0 | 4 | 1 | 1 | 4 | 2 | 1.60 | |
| Zach Kroenke | ARI | 8.10 | 1 | 1 | 0 | 7 | 1 | 10.0 | 15 | 9 | 9 | 5 | 5 | 2.00 | |
| Brad Lidge | WAS | 3.54 | 26 | 32 | 225 | 603 | 1 | 603.0 | 492 | 257 | 237 | 287 | 799 | 1.29 | |
| Dan Runzler | SF | 4.10 | 4 | 2 | 0 | 83 | 1 | 68.0 | 64 | 34 | 31 | 41 | 73 | 1.54 | |
| Aaron Thompson | MIN | 7.71 | 0 | 0 | 0 | 4 | 1 | 7.0 | 13 | 6 | 6 | 6 | 1 | 2.71 | |
| Tyler Thornburg | MIL | 9.00 | 0 | 0 | 0 | 1 | 1 | 5.0 | 7 | 5 | 5 | 0 | 2 | 1.40 | |
| Matt Thornton | CWS | 3.51 | 30 | 33 | 21 | 507 | 1 | 490.0 | 426 | 205 | 191 | 203 | 526 | 1.28 | |
| Raul Valdes | PHI | 4.23 | 5 | 4 | 1 | 62 | 1 | 83.0 | 80 | 40 | 39 | 34 | 84 | 1.37 | |
| Merkin Valdez | OAK | 5.63 | 3 | 1 | 0 | 74 | 1 | 72.0 | 84 | 49 | 45 | 42 | 59 | 1.75 | |
| Elih Villanueva | FLA | 24.00 | 0 | 1 | 0 | 1 | 1 | 3.0 | 5 | 8 | 8 | 5 | 2 | 3.33 |