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| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Brandon Beachy | ATL | 2.00 | 5 | 5 | 0 | 0 | 13 | 13 | 1 | 1 | 81 | 49 | 24 | 18 | 6 | 29 | 68 | 8 | 0.96 | .171 |
| 2 | Gio Gonzalez | WAS | 2.55 | 9 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 84.2 | 55 | 24 | 24 | 1 | 34 | 101 | 11 | 1.05 | .182 |
| 3 | R.A. Dickey | NYM | 2.00 | 11 | 1 | 0 | 0 | 14 | 14 | 3 | 2 | 99 | 67 | 24 | 22 | 8 | 21 | 103 | 13 | 0.89 | .194 |
| 4 | James McDonald | PIT | 2.19 | 6 | 3 | 0 | 0 | 14 | 14 | 1 | 0 | 90.1 | 62 | 24 | 22 | 4 | 24 | 83 | 10 | 0.95 | .195 |
| 5 | Matt Cain | SF | 2.34 | 9 | 2 | 0 | 0 | 14 | 14 | 2 | 2 | 100 | 71 | 30 | 26 | 8 | 20 | 100 | 10 | 0.91 | .199 |
| 6 | Ryan Dempster | CHC | 2.11 | 3 | 3 | 0 | 0 | 12 | 12 | 0 | 0 | 81 | 61 | 21 | 19 | 6 | 22 | 66 | 9 | 1.02 | .204 |
| 7 | Edwin Jackson | WAS | 3.02 | 3 | 4 | 0 | 0 | 13 | 13 | 1 | 0 | 86.1 | 66 | 31 | 29 | 8 | 25 | 63 | 9 | 1.05 | .213 |
| 8 | Clayton Kershaw | LAD | 2.73 | 5 | 3 | 0 | 0 | 15 | 15 | 1 | 1 | 102.1 | 78 | 34 | 31 | 10 | 25 | 95 | 10 | 1.01 | .214 |
| Johan Santana | NYM | 3.00 | 5 | 3 | 0 | 0 | 14 | 14 | 2 | 2 | 84 | 66 | 30 | 28 | 8 | 28 | 84 | 8 | 1.12 | .214 | |
| Stephen Strasburg | WAS | 2.46 | 9 | 1 | 0 | 0 | 14 | 14 | 0 | 0 | 84 | 65 | 26 | 23 | 6 | 22 | 110 | 11 | 1.04 | .214 | |
| 11 | Chris Capuano | LAD | 2.71 | 8 | 2 | 0 | 0 | 14 | 14 | 0 | 0 | 86.1 | 67 | 30 | 26 | 10 | 31 | 80 | 9 | 1.14 | .217 |
| 12 | Ryan Vogelsong | SF | 2.41 | 6 | 3 | 0 | 0 | 13 | 13 | 0 | 0 | 89.2 | 71 | 25 | 24 | 6 | 32 | 64 | 12 | 1.15 | .219 |
| 13 | Matt Garza | CHC | 4.07 | 3 | 5 | 0 | 0 | 13 | 13 | 0 | 0 | 77.1 | 64 | 38 | 35 | 11 | 22 | 72 | 9 | 1.11 | .223 |
| Lance Lynn | STL | 2.80 | 10 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 86.2 | 71 | 28 | 27 | 5 | 29 | 90 | 9 | 1.15 | .223 | |
| 15 | Carlos Zambrano | MIA | 4.01 | 4 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 83 | 66 | 38 | 37 | 6 | 42 | 63 | 9 | 1.30 | .224 |
| 16 | Wade Miley | ARI | 2.30 | 8 | 3 | 0 | 0 | 14 | 11 | 0 | 0 | 82.1 | 70 | 24 | 21 | 3 | 17 | 57 | 8 | 1.06 | .225 |
| 17 | Shaun Marcum | MIL | 3.39 | 5 | 3 | 0 | 0 | 13 | 13 | 0 | 0 | 82.1 | 70 | 33 | 31 | 10 | 26 | 77 | 9 | 1.17 | .227 |
| 18 | Edinson Volquez | SD | 4.11 | 3 | 7 | 0 | 0 | 15 | 15 | 0 | 0 | 87.2 | 73 | 41 | 40 | 7 | 51 | 76 | 8 | 1.41 | .229 |
| 19 | Randall Delgado | ATL | 4.12 | 4 | 7 | 0 | 0 | 13 | 13 | 0 | 0 | 74.1 | 62 | 35 | 34 | 6 | 37 | 60 | 4 | 1.33 | .230 |
| 20 | Madison Bumgarner | SF | 2.92 | 8 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 95.2 | 83 | 36 | 31 | 8 | 19 | 78 | 8 | 1.07 | .231 |
| 21 | Cole Hamels | PHI | 3.25 | 10 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 97 | 84 | 38 | 35 | 11 | 22 | 99 | 10 | 1.09 | .234 |
| 22 | A.J. Burnett | PIT | 3.24 | 8 | 2 | 0 | 0 | 12 | 12 | 0 | 0 | 75 | 66 | 28 | 27 | 6 | 27 | 62 | 9 | 1.24 | .235 |
| 23 | Jonathon Niese | NYM | 3.75 | 5 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 81.2 | 75 | 37 | 34 | 13 | 29 | 79 | 9 | 1.27 | .241 |
| 24 | Anibal Sanchez | MIA | 3.94 | 3 | 6 | 0 | 0 | 14 | 14 | 0 | 0 | 89 | 80 | 43 | 39 | 8 | 28 | 83 | 10 | 1.21 | .242 |
| 25 | Trevor Cahill | ARI | 3.47 | 6 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 90.2 | 80 | 38 | 35 | 4 | 34 | 67 | 8 | 1.26 | .245 |
| 26 | Jordan Zimmermann | WAS | 2.89 | 3 | 6 | 0 | 0 | 14 | 14 | 0 | 0 | 90.1 | 84 | 32 | 29 | 11 | 17 | 64 | 12 | 1.12 | .246 |
| 27 | Dillon Gee | NYM | 4.27 | 5 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 90.2 | 87 | 47 | 43 | 12 | 25 | 83 | 10 | 1.24 | .250 |
| Kyle Lohse | STL | 2.85 | 6 | 2 | 0 | 0 | 15 | 15 | 0 | 0 | 94.2 | 90 | 33 | 30 | 8 | 15 | 54 | 10 | 1.11 | .250 | |
| 29 | Anthony Bass | SD | 4.70 | 2 | 7 | 0 | 0 | 16 | 14 | 1 | 0 | 84.1 | 80 | 51 | 44 | 8 | 33 | 72 | 4 | 1.34 | .251 |
| Johnny Cueto | CIN | 2.38 | 8 | 3 | 0 | 0 | 14 | 14 | 2 | 0 | 94.2 | 89 | 27 | 25 | 5 | 20 | 67 | 11 | 1.15 | .251 | |
| 31 | Roy Halladay | PHI | 3.98 | 4 | 5 | 0 | 0 | 11 | 11 | 0 | 0 | 72.1 | 69 | 32 | 32 | 6 | 14 | 56 | 8 | 1.15 | .252 |
| 32 | Zack Greinke | MIL | 2.81 | 8 | 2 | 0 | 0 | 15 | 15 | 0 | 0 | 96 | 92 | 31 | 30 | 3 | 21 | 99 | 11 | 1.18 | .253 |
| Tommy Hanson | ATL | 3.54 | 8 | 4 | 0 | 0 | 15 | 15 | 0 | 0 | 86.1 | 82 | 37 | 34 | 14 | 35 | 74 | 7 | 1.36 | .253 | |
| Cliff Lee | PHI | 3.48 | 0 | 3 | 0 | 0 | 11 | 11 | 0 | 0 | 77.2 | 73 | 30 | 30 | 9 | 14 | 77 | 7 | 1.12 | .253 | |
| Barry Zito | SF | 4.35 | 5 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 80.2 | 78 | 45 | 39 | 11 | 36 | 45 | 7 | 1.41 | .253 | |
| 36 | Erik Bedard | PIT | 4.13 | 4 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 72 | 70 | 34 | 33 | 5 | 32 | 69 | 5 | 1.42 | .254 |
| 37 | Aaron Harang | LAD | 3.76 | 5 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 81.1 | 80 | 39 | 34 | 6 | 37 | 70 | 8 | 1.44 | .256 |
| Tim Lincecum | SF | 6.07 | 2 | 8 | 0 | 0 | 15 | 15 | 0 | 0 | 83 | 83 | 58 | 56 | 8 | 45 | 91 | 3 | 1.54 | .256 | |
| 39 | Yovani Gallardo | MIL | 4.22 | 6 | 5 | 0 | 0 | 15 | 15 | 0 | 0 | 89.2 | 88 | 44 | 42 | 12 | 38 | 90 | 12 | 1.41 | .257 |
| 40 | Clayton Richard | SD | 3.95 | 5 | 7 | 0 | 0 | 15 | 15 | 0 | 0 | 98 | 99 | 53 | 43 | 12 | 27 | 58 | 9 | 1.29 | .259 |
| 41 | Kevin Correia | PIT | 4.12 | 3 | 6 | 0 | 0 | 13 | 13 | 0 | 0 | 74.1 | 74 | 36 | 34 | 12 | 22 | 27 | 6 | 1.29 | .261 |
| Lucas Harrell | HOU | 4.77 | 6 | 6 | 0 | 0 | 15 | 15 | 0 | 0 | 88.2 | 89 | 55 | 47 | 8 | 31 | 49 | 5 | 1.35 | .261 | |
| 43 | Mark Buehrle | MIA | 3.82 | 5 | 8 | 0 | 0 | 14 | 14 | 1 | 0 | 92 | 92 | 42 | 39 | 12 | 13 | 44 | 9 | 1.14 | .263 |
| Bud Norris | HOU | 4.81 | 5 | 4 | 0 | 0 | 13 | 13 | 0 | 0 | 73 | 76 | 41 | 39 | 10 | 28 | 81 | 7 | 1.42 | .263 | |
| Adam Wainwright | STL | 4.46 | 5 | 7 | 0 | 0 | 14 | 14 | 1 | 1 | 84.2 | 85 | 45 | 42 | 8 | 26 | 80 | 6 | 1.31 | .263 | |
| 46 | Jeff Samardzija | CHC | 4.34 | 5 | 6 | 0 | 0 | 14 | 14 | 0 | 0 | 83 | 84 | 42 | 40 | 7 | 30 | 84 | 7 | 1.37 | .264 |
| 47 | Homer Bailey | CIN | 4.20 | 5 | 5 | 0 | 0 | 14 | 14 | 1 | 0 | 85.2 | 89 | 45 | 40 | 12 | 26 | 60 | 10 | 1.34 | .265 |
| Wandy Rodriguez | HOU | 3.29 | 6 | 5 | 0 | 0 | 15 | 15 | 0 | 0 | 95.2 | 99 | 44 | 35 | 12 | 22 | 61 | 10 | 1.26 | .265 | |
| 49 | Jake Westbrook | STL | 3.83 | 6 | 6 | 0 | 0 | 14 | 14 | 1 | 0 | 87 | 92 | 42 | 37 | 7 | 23 | 59 | 9 | 1.32 | .266 |
| 50 | Paul Maholm | CHC | 4.88 | 4 | 5 | 0 | 0 | 13 | 13 | 0 | 0 | 72 | 73 | 39 | 39 | 10 | 22 | 49 | 6 | 1.32 | .267 |
| 51 | Chad Billingsley | LAD | 4.15 | 4 | 6 | 0 | 0 | 15 | 15 | 0 | 0 | 86.2 | 90 | 47 | 40 | 9 | 31 | 80 | 7 | 1.40 | .268 |
| Mike Minor | ATL | 6.04 | 3 | 5 | 0 | 0 | 13 | 13 | 0 | 0 | 76 | 77 | 53 | 51 | 15 | 30 | 66 | 4 | 1.41 | .268 | |
| 53 | Ian Kennedy | ARI | 4.13 | 5 | 7 | 0 | 0 | 14 | 14 | 1 | 0 | 89.1 | 95 | 42 | 41 | 11 | 20 | 81 | 9 | 1.29 | .271 |
| 54 | Mat Latos | CIN | 5.20 | 5 | 2 | 0 | 0 | 14 | 14 | 0 | 0 | 79.2 | 86 | 50 | 46 | 16 | 26 | 70 | 5 | 1.41 | .274 |
| 55 | Joe Blanton | PHI | 5.04 | 6 | 6 | 0 | 0 | 15 | 14 | 2 | 1 | 91 | 102 | 55 | 51 | 17 | 12 | 74 | 6 | 1.25 | .277 |
| 56 | Ricky Nolasco | MIA | 5.16 | 6 | 6 | 0 | 0 | 14 | 14 | 0 | 0 | 83.2 | 92 | 49 | 48 | 10 | 24 | 50 | 7 | 1.39 | .283 |
| Joe Saunders | ARI | 3.44 | 4 | 5 | 0 | 0 | 13 | 13 | 1 | 1 | 81 | 91 | 36 | 31 | 9 | 21 | 53 | 9 | 1.38 | .283 | |
| 58 | Mike Leake | CIN | 4.70 | 2 | 5 | 0 | 0 | 13 | 13 | 0 | 0 | 74.2 | 83 | 44 | 39 | 9 | 21 | 53 | 6 | 1.39 | .284 |
| 59 | J.A. Happ | HOU | 5.15 | 5 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 78.2 | 90 | 47 | 45 | 13 | 31 | 79 | 9 | 1.54 | .288 |
| 60 | Bronson Arroyo | CIN | 4.19 | 3 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 86 | 99 | 42 | 40 | 15 | 14 | 60 | 7 | 1.31 | .290 |
| 61 | Josh Johnson | MIA | 4.18 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 84 | 96 | 39 | 39 | 4 | 27 | 70 | 10 | 1.46 | .296 |
| 62 | Randy Wolf | MIL | 5.11 | 2 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 81 | 96 | 49 | 46 | 8 | 31 | 48 | 5 | 1.57 | .298 |