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| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Brandon Morrow | TOR | 3.01 | 7 | 4 | 0 | 0 | 13 | 13 | 3 | 3 | 77.2 | 54 | 28 | 26 | 7 | 24 | 67 | 8 | 1.00 | .194 |
| 2 | Matt Cain | SF | 2.34 | 9 | 2 | 0 | 0 | 14 | 14 | 2 | 2 | 100 | 71 | 30 | 26 | 8 | 20 | 100 | 10 | 0.91 | .199 |
| R.A. Dickey | NYM | 2.00 | 11 | 1 | 0 | 0 | 14 | 14 | 3 | 2 | 99 | 67 | 24 | 22 | 8 | 21 | 103 | 13 | 0.89 | .194 | |
| Johan Santana | NYM | 3.00 | 5 | 3 | 0 | 0 | 14 | 14 | 2 | 2 | 84 | 66 | 30 | 28 | 8 | 28 | 84 | 8 | 1.12 | .214 | |
| 5 | Henderson Alvarez | TOR | 4.30 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 90 | 103 | 47 | 43 | 16 | 20 | 27 | 8 | 1.37 | .289 |
| Brandon Beachy | ATL | 2.00 | 5 | 5 | 0 | 0 | 13 | 13 | 1 | 1 | 81 | 49 | 24 | 18 | 6 | 29 | 68 | 8 | 0.96 | .171 | |
| Joe Blanton | PHI | 5.04 | 6 | 6 | 0 | 0 | 15 | 14 | 2 | 1 | 91 | 102 | 55 | 51 | 17 | 12 | 74 | 6 | 1.25 | .277 | |
| Clay Buchholz | BOS | 5.53 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 86.1 | 99 | 55 | 53 | 15 | 34 | 58 | 5 | 1.54 | .295 | |
| Trevor Cahill | ARI | 3.47 | 6 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 90.2 | 80 | 38 | 35 | 4 | 34 | 67 | 8 | 1.26 | .245 | |
| Jason Hammel | BAL | 2.61 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 89.2 | 71 | 29 | 26 | 7 | 29 | 87 | 8 | 1.12 | .215 | |
| Dan Haren | LAA | 4.24 | 5 | 7 | 0 | 0 | 15 | 15 | 1 | 1 | 93.1 | 106 | 46 | 44 | 13 | 22 | 82 | 7 | 1.37 | .289 | |
| Matt Harrison | TEX | 3.41 | 9 | 3 | 0 | 0 | 14 | 14 | 1 | 1 | 92.1 | 93 | 36 | 35 | 7 | 22 | 55 | 10 | 1.25 | .261 | |
| Tim Hudson | ATL | 3.88 | 5 | 3 | 0 | 0 | 10 | 10 | 1 | 1 | 65 | 59 | 30 | 28 | 2 | 20 | 44 | 5 | 1.22 | .242 | |
| Philip Humber | CWS | 6.01 | 3 | 4 | 0 | 0 | 12 | 12 | 1 | 1 | 67.1 | 69 | 46 | 45 | 12 | 31 | 63 | 5 | 1.49 | .261 | |
| Kyle Kendrick | PHI | 5.29 | 2 | 7 | 0 | 1 | 15 | 10 | 1 | 1 | 63 | 74 | 41 | 37 | 8 | 23 | 40 | 4 | 1.54 | .301 | |
| Clayton Kershaw | LAD | 2.73 | 5 | 3 | 0 | 0 | 15 | 15 | 1 | 1 | 102.1 | 78 | 34 | 31 | 10 | 25 | 95 | 10 | 1.01 | .214 | |
| Derek Lowe | CLE | 4.30 | 7 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 83.2 | 105 | 42 | 40 | 5 | 27 | 30 | 10 | 1.58 | .313 | |
| Kevin Millwood | SEA | 4.02 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 80.2 | 79 | 43 | 36 | 3 | 33 | 59 | 6 | 1.39 | .257 | |
| Jake Peavy | CWS | 2.74 | 6 | 3 | 0 | 0 | 14 | 14 | 3 | 1 | 98.2 | 70 | 32 | 30 | 8 | 23 | 83 | 12 | 0.94 | .198 | |
| David Price | TB | 3.08 | 9 | 4 | 0 | 0 | 14 | 14 | 1 | 1 | 90.2 | 84 | 33 | 31 | 7 | 31 | 82 | 9 | 1.27 | .248 | |
| Ervin Santana | LAA | 5.16 | 4 | 7 | 0 | 0 | 14 | 14 | 1 | 1 | 89 | 83 | 52 | 51 | 18 | 36 | 61 | 6 | 1.34 | .243 | |
| Joe Saunders | ARI | 3.44 | 4 | 5 | 0 | 0 | 13 | 13 | 1 | 1 | 81 | 91 | 36 | 31 | 9 | 21 | 53 | 9 | 1.38 | .283 | |
| Justin Verlander | DET | 2.57 | 7 | 4 | 0 | 0 | 15 | 15 | 3 | 1 | 108.2 | 81 | 37 | 31 | 6 | 27 | 106 | 12 | 0.99 | .204 | |
| Adam Wainwright | STL | 4.46 | 5 | 7 | 0 | 0 | 14 | 14 | 1 | 1 | 84.2 | 85 | 45 | 42 | 8 | 26 | 80 | 6 | 1.31 | .263 | |
| Jered Weaver | LAA | 2.40 | 7 | 1 | 0 | 0 | 12 | 12 | 2 | 1 | 75 | 51 | 23 | 20 | 5 | 17 | 60 | 9 | 0.91 | .189 | |
| Jerome Williams | LAA | 4.46 | 6 | 5 | 0 | 0 | 13 | 12 | 1 | 1 | 82.2 | 88 | 44 | 41 | 7 | 26 | 56 | 8 | 1.38 | .273 | |
| Carlos Zambrano | MIA | 4.01 | 4 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 83 | 66 | 38 | 37 | 6 | 42 | 63 | 9 | 1.30 | .224 | |
| Barry Zito | SF | 4.35 | 5 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 80.2 | 78 | 45 | 39 | 11 | 36 | 45 | 7 | 1.41 | .253 |