| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Chris Perez | CLE | 2.54 | 0 | 1 | 23 | 24 | 30 | 0 | 0 | 0 | 28.1 | 21 | 8 | 8 | 0 | 7 | 28 | 0 | 0.99 | .198 |
| 2 | Jim Johnson | BAL | 1.14 | 1 | 0 | 21 | 22 | 31 | 0 | 0 | 0 | 31.2 | 15 | 4 | 4 | 3 | 6 | 19 | 0 | 0.66 | .140 |
| Craig Kimbrel | ATL | 1.33 | 0 | 0 | 21 | 22 | 27 | 0 | 0 | 0 | 27 | 12 | 4 | 4 | 0 | 10 | 44 | 0 | 0.81 | .129 | |
| 4 | Alfredo Aceves | BOS | 4.54 | 0 | 4 | 18 | 21 | 34 | 0 | 0 | 0 | 35.2 | 31 | 18 | 18 | 3 | 13 | 39 | 0 | 1.23 | .235 |
| Jonathan Broxton | KC | 1.57 | 1 | 1 | 18 | 21 | 28 | 0 | 0 | 0 | 28.2 | 27 | 7 | 5 | 1 | 10 | 22 | 0 | 1.29 | .255 | |
| Santiago Casilla | SF | 1.59 | 1 | 2 | 20 | 21 | 31 | 0 | 0 | 0 | 28.1 | 21 | 7 | 5 | 4 | 8 | 25 | 0 | 1.02 | .191 | |
| Frank Francisco | NYM | 4.97 | 1 | 3 | 18 | 21 | 31 | 0 | 0 | 0 | 29 | 32 | 17 | 16 | 3 | 14 | 31 | 0 | 1.59 | .264 | |
| Fernando Rodney | TB | 1.10 | 2 | 1 | 20 | 21 | 34 | 0 | 0 | 0 | 32.2 | 20 | 6 | 4 | 1 | 5 | 31 | 0 | 0.77 | .174 | |
| 9 | Joel Hanrahan | PIT | 2.33 | 3 | 0 | 18 | 20 | 28 | 0 | 0 | 0 | 27 | 15 | 7 | 7 | 4 | 13 | 33 | 0 | 1.04 | .160 |
| 10 | Heath Bell | MIA | 5.47 | 2 | 3 | 14 | 18 | 31 | 0 | 0 | 0 | 26.1 | 30 | 18 | 16 | 1 | 16 | 26 | 0 | 1.75 | .286 |
| Jason Motte | STL | 3.41 | 3 | 3 | 14 | 18 | 28 | 0 | 0 | 0 | 31.2 | 21 | 12 | 12 | 5 | 11 | 31 | 0 | 1.01 | .194 | |
| 12 | John Axford | MIL | 5.08 | 1 | 4 | 13 | 17 | 30 | 0 | 0 | 0 | 28.1 | 26 | 20 | 16 | 3 | 18 | 39 | 0 | 1.55 | .230 |
| Brett Myers | HOU | 3.86 | 0 | 2 | 16 | 17 | 26 | 0 | 0 | 0 | 23.1 | 23 | 10 | 10 | 3 | 4 | 16 | 0 | 1.16 | .258 | |
| Joe Nathan | TEX | 1.52 | 0 | 2 | 16 | 17 | 30 | 0 | 0 | 0 | 29.2 | 23 | 6 | 5 | 2 | 2 | 36 | 0 | 0.84 | .213 | |
| Jonathan Papelbon | PHI | 2.28 | 1 | 2 | 17 | 17 | 28 | 0 | 0 | 0 | 27.2 | 21 | 7 | 7 | 3 | 6 | 33 | 0 | 0.98 | .206 | |
| 16 | J.J. Putz | ARI | 5.73 | 1 | 4 | 13 | 16 | 23 | 0 | 0 | 0 | 22 | 23 | 14 | 14 | 4 | 5 | 24 | 0 | 1.27 | .261 |
| Jose Valverde | DET | 4.18 | 3 | 2 | 13 | 16 | 29 | 0 | 0 | 0 | 28 | 25 | 18 | 13 | 2 | 17 | 19 | 0 | 1.50 | .238 | |
| 18 | Matt Capps | MIN | 3.55 | 1 | 4 | 14 | 15 | 26 | 0 | 0 | 0 | 25.1 | 23 | 10 | 10 | 4 | 3 | 15 | 0 | 1.03 | .235 |
| 19 | Rafael Betancourt | COL | 3.16 | 1 | 3 | 11 | 14 | 26 | 0 | 0 | 0 | 25.2 | 20 | 10 | 9 | 2 | 7 | 26 | 0 | 1.05 | .211 |
| Kenley Jansen | LAD | 2.51 | 4 | 2 | 11 | 14 | 32 | 0 | 0 | 0 | 32.1 | 17 | 9 | 9 | 4 | 12 | 51 | 0 | 0.90 | .150 | |
| Rafael Soriano | NYY | 1.78 | 2 | 0 | 13 | 14 | 27 | 0 | 0 | 0 | 25.1 | 26 | 5 | 5 | 0 | 10 | 22 | 0 | 1.42 | .257 | |
| 22 | Brandon League | SEA | 3.77 | 0 | 4 | 9 | 13 | 31 | 0 | 0 | 0 | 31 | 33 | 14 | 13 | 1 | 15 | 20 | 0 | 1.55 | .280 |
| 23 | Tyler Clippard | WAS | 2.01 | 1 | 2 | 11 | 12 | 32 | 0 | 0 | 0 | 31.1 | 15 | 8 | 7 | 0 | 14 | 38 | 0 | 0.93 | .140 |
| Henry Rodriguez | WAS | 5.14 | 1 | 3 | 9 | 12 | 24 | 0 | 0 | 0 | 21 | 13 | 13 | 12 | 3 | 14 | 23 | 0 | 1.29 | .176 | |
| 25 | Aroldis Chapman | CIN | 1.57 | 4 | 3 | 8 | 11 | 30 | 0 | 0 | 0 | 34.1 | 14 | 7 | 6 | 2 | 11 | 59 | 0 | 0.73 | .119 |
| Javy Guerra | LAD | 3.38 | 2 | 3 | 8 | 11 | 27 | 0 | 0 | 0 | 24 | 26 | 9 | 9 | 0 | 10 | 20 | 0 | 1.50 | .289 | |
| 27 | Sean Marshall | CIN | 2.83 | 1 | 3 | 9 | 10 | 33 | 0 | 0 | 0 | 28.2 | 28 | 9 | 9 | 2 | 6 | 36 | 0 | 1.19 | .246 |
| 28 | Grant Balfour | OAK | 2.75 | 1 | 1 | 7 | 9 | 35 | 0 | 0 | 0 | 36 | 23 | 11 | 11 | 3 | 15 | 29 | 0 | 1.06 | .185 |
| Addison Reed | CWS | 4.18 | 1 | 1 | 8 | 9 | 27 | 0 | 0 | 0 | 23.2 | 20 | 11 | 11 | 1 | 9 | 26 | 0 | 1.23 | .222 | |
| Huston Street | SD | 1.69 | 1 | 0 | 9 | 9 | 17 | 0 | 0 | 0 | 16 | 8 | 3 | 3 | 0 | 5 | 20 | 0 | 0.81 | .145 | |
| 31 | Scott Downs | LAA | 0.37 | 0 | 0 | 6 | 8 | 27 | 0 | 0 | 0 | 24.1 | 20 | 2 | 1 | 0 | 5 | 16 | 0 | 1.03 | .222 |
| Ernesto Frieri | LAA | 0.84 | 1 | 0 | 8 | 8 | 32 | 0 | 0 | 0 | 32.1 | 12 | 5 | 3 | 2 | 18 | 54 | 0 | 0.93 | .112 | |
| Brian Fuentes | OAK | 5.79 | 2 | 2 | 5 | 8 | 24 | 0 | 0 | 0 | 23.1 | 26 | 15 | 15 | 4 | 6 | 17 | 0 | 1.37 | .277 | |
| Casey Janssen | TOR | 2.70 | 1 | 1 | 7 | 8 | 26 | 0 | 0 | 0 | 26.2 | 21 | 8 | 8 | 4 | 5 | 23 | 0 | 0.98 | .216 | |
| 35 | Ryan Cook | OAK | 1.71 | 2 | 2 | 4 | 6 | 31 | 0 | 0 | 0 | 31.2 | 11 | 6 | 6 | 0 | 20 | 33 | 0 | 0.98 | .109 |
| Rafael Dolis | CHC | 5.68 | 2 | 4 | 4 | 6 | 23 | 0 | 0 | 0 | 25.1 | 21 | 18 | 16 | 2 | 17 | 11 | 0 | 1.50 | .236 | |
| David Hernandez | ARI | 2.90 | 0 | 1 | 2 | 6 | 33 | 0 | 0 | 0 | 31 | 22 | 12 | 10 | 2 | 12 | 45 | 0 | 1.10 | .193 | |
| Carlos Marmol | CHC | 5.49 | 1 | 2 | 4 | 6 | 24 | 0 | 0 | 0 | 19.2 | 15 | 14 | 12 | 2 | 23 | 22 | 0 | 1.93 | .200 | |
| Mariano Rivera | NYY | 2.16 | 1 | 1 | 5 | 6 | 9 | 0 | 0 | 0 | 8.1 | 6 | 2 | 2 | 0 | 2 | 8 | 0 | 0.96 | .200 | |
| Hector Santiago | CWS | 4.15 | 1 | 1 | 4 | 6 | 23 | 0 | 0 | 0 | 26 | 25 | 12 | 12 | 6 | 11 | 30 | 0 | 1.38 | .245 | |
| Pedro Strop | BAL | 1.38 | 3 | 2 | 3 | 6 | 29 | 0 | 0 | 0 | 32.2 | 19 | 5 | 5 | 1 | 18 | 28 | 0 | 1.13 | .174 | |
| Dale Thayer | SD | 6.16 | 0 | 2 | 5 | 6 | 21 | 0 | 0 | 0 | 19 | 24 | 13 | 13 | 3 | 4 | 16 | 0 | 1.47 | .320 | |
| Tom Wilhelmsen | SEA | 3.00 | 3 | 1 | 5 | 6 | 32 | 0 | 0 | 0 | 36 | 29 | 14 | 12 | 3 | 11 | 44 | 0 | 1.11 | .216 | |
| 44 | Francisco Cordero | TOR | 5.08 | 2 | 4 | 2 | 5 | 33 | 0 | 0 | 0 | 28.1 | 36 | 18 | 16 | 5 | 13 | 21 | 0 | 1.73 | .319 |
| Edward Mujica | MIA | 4.22 | 0 | 3 | 2 | 5 | 31 | 0 | 0 | 0 | 32 | 28 | 17 | 15 | 4 | 8 | 16 | 0 | 1.13 | .230 | |
| Joel Peralta | TB | 4.20 | 0 | 3 | 2 | 5 | 36 | 0 | 0 | 0 | 30 | 23 | 14 | 14 | 5 | 8 | 36 | 0 | 1.03 | .207 | |
| Chad Qualls | PHI | 4.18 | 1 | 1 | 0 | 5 | 31 | 0 | 0 | 0 | 28 | 35 | 15 | 13 | 6 | 7 | 19 | 0 | 1.50 | .299 | |
| Marc Rzepczynski | STL | 5.47 | 1 | 3 | 0 | 5 | 34 | 0 | 0 | 0 | 24.2 | 28 | 15 | 15 | 5 | 8 | 18 | 0 | 1.46 | .289 | |
| 49 | Rex Brothers | COL | 4.13 | 2 | 2 | 0 | 4 | 32 | 0 | 0 | 0 | 24 | 25 | 15 | 11 | 1 | 15 | 35 | 0 | 1.67 | .272 |
| Andrew Cashner | SD | 3.81 | 3 | 3 | 0 | 4 | 28 | 1 | 0 | 0 | 28.1 | 25 | 13 | 12 | 3 | 18 | 34 | 0 | 1.52 | .243 | |
| Steve Cishek | MIA | 2.45 | 4 | 0 | 1 | 4 | 30 | 0 | 0 | 0 | 29.1 | 24 | 10 | 8 | 2 | 15 | 29 | 0 | 1.33 | .229 | |
| Brad Lidge | WAS | 9.64 | 0 | 1 | 2 | 4 | 11 | 0 | 0 | 0 | 9.1 | 12 | 10 | 10 | 1 | 11 | 10 | 0 | 2.46 | .308 | |
| Glen Perkins | MIN | 2.93 | 1 | 1 | 2 | 4 | 32 | 0 | 0 | 0 | 30.2 | 28 | 12 | 10 | 3 | 13 | 40 | 0 | 1.34 | .248 | |
| Jon Rauch | NYM | 4.28 | 3 | 6 | 1 | 4 | 32 | 0 | 0 | 0 | 27.1 | 27 | 14 | 13 | 2 | 5 | 18 | 0 | 1.17 | .252 | |
| Sergio Santos | TOR | 9.00 | 0 | 1 | 2 | 4 | 6 | 0 | 0 | 0 | 5 | 6 | 5 | 5 | 1 | 4 | 4 | 0 | 2.00 | .316 | |
| Matt Thornton | CWS | 3.23 | 2 | 5 | 1 | 4 | 35 | 0 | 0 | 0 | 30.2 | 30 | 12 | 11 | 2 | 9 | 27 | 0 | 1.27 | .254 | |
| 57 | Matt Albers | BOS | 1.88 | 2 | 0 | 0 | 3 | 26 | 0 | 0 | 0 | 28.2 | 21 | 10 | 6 | 3 | 7 | 19 | 0 | 0.98 | .200 |
| Luis Ayala | BAL | 1.95 | 2 | 1 | 1 | 3 | 28 | 0 | 0 | 0 | 32.1 | 29 | 9 | 7 | 2 | 6 | 22 | 0 | 1.08 | .230 | |
| Matt Belisle | COL | 2.13 | 3 | 2 | 0 | 3 | 35 | 0 | 0 | 0 | 38 | 38 | 11 | 9 | 1 | 6 | 30 | 0 | 1.16 | .250 | |
| Shawn Camp | CHC | 3.35 | 2 | 4 | 1 | 3 | 35 | 0 | 0 | 0 | 37.2 | 36 | 14 | 14 | 3 | 10 | 30 | 0 | 1.22 | .250 | |
| Jesse Crain | CWS | 2.45 | 1 | 1 | 0 | 3 | 23 | 0 | 0 | 0 | 22 | 16 | 7 | 6 | 2 | 8 | 26 | 0 | 1.09 | .195 | |
| Aaron Crow | KC | 2.73 | 0 | 1 | 1 | 3 | 33 | 0 | 0 | 0 | 29.2 | 23 | 10 | 9 | 1 | 12 | 28 | 0 | 1.18 | .215 | |
| Juan Cruz | PIT | 2.66 | 1 | 1 | 3 | 3 | 28 | 0 | 0 | 0 | 23.2 | 28 | 8 | 7 | 2 | 11 | 25 | 0 | 1.65 | .308 | |
| Octavio Dotel | DET | 4.19 | 1 | 2 | 1 | 3 | 22 | 0 | 0 | 0 | 19.1 | 14 | 9 | 9 | 2 | 6 | 29 | 0 | 1.03 | .194 | |
| Javier Lopez | SF | 2.93 | 3 | 0 | 1 | 3 | 31 | 0 | 0 | 0 | 15.1 | 19 | 7 | 5 | 0 | 8 | 13 | 0 | 1.76 | .297 | |
| Eric O'Flaherty | ATL | 3.60 | 1 | 0 | 0 | 3 | 28 | 0 | 0 | 0 | 25 | 26 | 12 | 10 | 3 | 10 | 21 | 0 | 1.44 | .277 | |
| Alexi Ogando | TEX | 2.08 | 1 | 0 | 1 | 3 | 28 | 1 | 0 | 0 | 34.2 | 21 | 8 | 8 | 2 | 7 | 35 | 0 | 0.81 | .175 | |
| Logan Ondrusek | CIN | 3.00 | 3 | 1 | 2 | 3 | 32 | 0 | 0 | 0 | 27 | 22 | 9 | 9 | 3 | 13 | 17 | 0 | 1.30 | .224 | |
| Bobby Parnell | NYM | 3.30 | 1 | 1 | 0 | 3 | 35 | 0 | 0 | 0 | 30 | 33 | 14 | 11 | 3 | 8 | 30 | 0 | 1.37 | .264 | |
| Ramon Ramirez | NYM | 4.78 | 2 | 1 | 1 | 3 | 22 | 0 | 0 | 0 | 26.1 | 29 | 15 | 14 | 2 | 11 | 25 | 0 | 1.52 | .290 | |
| Francisco Rodriguez | MIL | 3.90 | 0 | 4 | 1 | 3 | 35 | 0 | 0 | 0 | 32.1 | 35 | 15 | 14 | 3 | 11 | 30 | 0 | 1.42 | .278 | |
| Sergio Romo | SF | 0.93 | 2 | 1 | 3 | 3 | 26 | 0 | 0 | 0 | 19.1 | 10 | 2 | 2 | 1 | 5 | 25 | 0 | 0.78 | .149 | |
| Bryan Shaw | ARI | 3.10 | 1 | 3 | 2 | 3 | 32 | 0 | 0 | 0 | 29 | 25 | 11 | 10 | 3 | 10 | 20 | 0 | 1.21 | .243 | |
| 74 | Mike Adams | TEX | 3.00 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 24 | 25 | 10 | 8 | 1 | 5 | 19 | 0 | 1.25 | .263 |
| Jeremy Affeldt | SF | 2.77 | 0 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 26 | 25 | 12 | 8 | 1 | 8 | 23 | 0 | 1.27 | .248 | |
| Jose Arredondo | CIN | 2.05 | 4 | 1 | 1 | 2 | 31 | 0 | 0 | 0 | 30.2 | 16 | 7 | 7 | 3 | 16 | 34 | 0 | 1.04 | .152 | |
| Joaquin Benoit | DET | 1.93 | 1 | 1 | 1 | 2 | 33 | 0 | 0 | 0 | 32.2 | 26 | 9 | 7 | 1 | 14 | 44 | 0 | 1.22 | .222 | |
| Mitchell Boggs | STL | 2.30 | 1 | 1 | 0 | 2 | 31 | 0 | 0 | 0 | 31.1 | 24 | 10 | 8 | 2 | 9 | 25 | 0 | 1.05 | .214 | |
| Bill Bray | CIN | 12.00 | 0 | 0 | 0 | 2 | 6 | 0 | 0 | 0 | 3 | 5 | 4 | 4 | 2 | 4 | 3 | 0 | 3.00 | .417 | |
| Sean Burnett | WAS | 1.08 | 0 | 0 | 2 | 2 | 30 | 0 | 0 | 0 | 25 | 16 | 3 | 3 | 1 | 6 | 25 | 0 | 0.88 | .182 | |
| Bobby Cassevah | LAA | 7.20 | 1 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 5 | 5 | 4 | 4 | 2 | 6 | 2 | 0 | 2.20 | .263 | |
| Phil Coke | DET | 3.45 | 1 | 3 | 1 | 2 | 33 | 0 | 0 | 0 | 31.1 | 37 | 15 | 12 | 1 | 8 | 29 | 0 | 1.44 | .303 | |
| Jason Frasor | TOR | 4.10 | 0 | 1 | 0 | 2 | 31 | 0 | 0 | 0 | 26.1 | 25 | 12 | 12 | 3 | 16 | 35 | 0 | 1.56 | .253 | |
| Luke Gregerson | SD | 3.73 | 1 | 0 | 0 | 2 | 33 | 0 | 0 | 0 | 31.1 | 28 | 13 | 13 | 4 | 13 | 33 | 0 | 1.31 | .241 | |
| Jason Grilli | PIT | 1.95 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 27.2 | 15 | 7 | 6 | 3 | 15 | 43 | 0 | 1.08 | .155 | |
| Nick Hagadone | CLE | 4.91 | 1 | 0 | 1 | 2 | 23 | 0 | 0 | 0 | 22 | 18 | 12 | 12 | 3 | 11 | 23 | 0 | 1.32 | .217 | |
| Clay Hensley | SF | 3.62 | 3 | 3 | 1 | 2 | 31 | 0 | 0 | 0 | 27.1 | 24 | 15 | 11 | 1 | 19 | 24 | 0 | 1.57 | .235 | |
| Greg Holland | KC | 3.75 | 2 | 2 | 0 | 2 | 26 | 0 | 0 | 0 | 24 | 24 | 10 | 10 | 0 | 15 | 34 | 0 | 1.63 | .264 | |
| Hisashi Iwakuma | SEA | 5.06 | 1 | 0 | 2 | 2 | 13 | 0 | 0 | 0 | 26.2 | 27 | 15 | 15 | 5 | 13 | 20 | 0 | 1.50 | .270 | |
| Kevin Jepsen | LAA | 10.29 | 0 | 1 | 0 | 2 | 9 | 0 | 0 | 0 | 7 | 9 | 9 | 8 | 1 | 2 | 4 | 0 | 1.57 | .346 | |
| Josh Lindblom | LAD | 2.91 | 2 | 1 | 0 | 2 | 32 | 0 | 0 | 0 | 34 | 24 | 11 | 11 | 7 | 12 | 29 | 0 | 1.06 | .205 | |
| Kameron Loe | MIL | 3.16 | 4 | 2 | 0 | 2 | 28 | 0 | 0 | 0 | 31.1 | 29 | 16 | 11 | 4 | 9 | 20 | 0 | 1.21 | .246 | |
| Kris Medlen | ATL | 3.34 | 1 | 1 | 1 | 2 | 24 | 0 | 0 | 0 | 32.1 | 31 | 12 | 12 | 1 | 8 | 18 | 0 | 1.21 | .261 | |
| Jordan Norberto | OAK | 3.91 | 0 | 1 | 1 | 2 | 21 | 0 | 0 | 0 | 25.1 | 16 | 11 | 11 | 1 | 12 | 18 | 0 | 1.11 | .184 | |
| Adam Ottavino | COL | 3.20 | 1 | 0 | 0 | 2 | 19 | 0 | 0 | 0 | 19.2 | 18 | 7 | 7 | 3 | 7 | 24 | 0 | 1.27 | .250 | |
| Vicente Padilla | BOS | 4.15 | 1 | 0 | 1 | 2 | 26 | 0 | 0 | 0 | 26 | 29 | 13 | 12 | 2 | 6 | 25 | 0 | 1.35 | .282 | |
| David Robertson | NYY | 2.76 | 0 | 1 | 1 | 2 | 17 | 0 | 0 | 0 | 16.1 | 14 | 5 | 5 | 1 | 6 | 26 | 0 | 1.22 | .230 | |
| Esmil Rogers | CLE | 6.89 | 0 | 2 | 0 | 2 | 27 | 0 | 0 | 0 | 31.1 | 39 | 25 | 24 | 3 | 18 | 36 | 0 | 1.82 | .295 | |
| Jonny Venters | ATL | 3.90 | 3 | 3 | 0 | 2 | 34 | 0 | 0 | 0 | 27.2 | 34 | 14 | 12 | 4 | 15 | 36 | 0 | 1.77 | .306 | |
| Jose Veras | MIL | 3.90 | 3 | 2 | 1 | 2 | 32 | 0 | 0 | 0 | 30 | 30 | 14 | 13 | 1 | 19 | 33 | 0 | 1.63 | .252 | |
| Jordan Walden | LAA | 2.86 | 2 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 22 | 18 | 7 | 7 | 1 | 13 | 25 | 0 | 1.41 | .214 | |
| Kerry Wood | CHC | 8.31 | 0 | 2 | 0 | 2 | 10 | 0 | 0 | 0 | 8.2 | 8 | 8 | 8 | 1 | 11 | 6 | 0 | 2.19 | .267 | |
| Brad Ziegler | ARI | 2.48 | 4 | 1 | 0 | 2 | 33 | 0 | 0 | 0 | 29 | 26 | 9 | 8 | 0 | 10 | 19 | 0 | 1.24 | .255 | |
| 104 | Manny Acosta | NYM | 11.86 | 1 | 2 | 0 | 1 | 19 | 0 | 0 | 0 | 22 | 35 | 33 | 29 | 6 | 15 | 23 | 0 | 2.27 | .361 |
| Scott Atchison | BOS | 1.17 | 2 | 0 | 0 | 1 | 29 | 0 | 0 | 0 | 38.1 | 27 | 5 | 5 | 1 | 7 | 29 | 0 | 0.89 | .199 | |
| Antonio Bastardo | PHI | 2.42 | 2 | 1 | 0 | 1 | 27 | 0 | 0 | 0 | 22.1 | 15 | 6 | 6 | 2 | 11 | 32 | 0 | 1.16 | .188 | |
| Ronald Belisario | LAD | 1.21 | 3 | 0 | 0 | 1 | 22 | 0 | 0 | 0 | 22.1 | 9 | 3 | 3 | 1 | 12 | 15 | 0 | 0.94 | .125 | |
| Michael Bowden | CHC | 6.39 | 0 | 0 | 0 | 1 | 12 | 0 | 0 | 0 | 12.2 | 16 | 9 | 9 | 3 | 6 | 11 | 0 | 1.74 | .320 | |
| Jared Burton | MIN | 3.10 | 1 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 29 | 22 | 11 | 10 | 4 | 3 | 29 | 0 | 0.86 | .206 | |
| Tim Byrdak | NYM | 3.38 | 2 | 0 | 0 | 1 | 37 | 0 | 0 | 0 | 18.2 | 10 | 7 | 7 | 1 | 9 | 22 | 0 | 1.02 | .167 | |
| David Carpenter | HOU | 5.40 | 0 | 2 | 0 | 1 | 25 | 0 | 0 | 0 | 26.2 | 38 | 17 | 16 | 4 | 13 | 25 | 0 | 1.91 | .336 | |
| Xavier Cedeno | HOU | 3.12 | 0 | 0 | 1 | 1 | 10 | 0 | 0 | 0 | 8.2 | 9 | 3 | 3 | 1 | 4 | 7 | 0 | 1.50 | .273 | |
| Tyler Chatwood | COL | 5.63 | 1 | 0 | 1 | 1 | 4 | 0 | 0 | 0 | 8 | 11 | 5 | 5 | 1 | 1 | 7 | 0 | 1.50 | .333 | |
| Randy Choate | MIA | 2.49 | 0 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 21.2 | 13 | 10 | 6 | 0 | 8 | 19 | 0 | 0.97 | .169 | |
| Casey Coleman | CHC | 4.76 | 0 | 1 | 0 | 1 | 14 | 0 | 0 | 0 | 17 | 23 | 9 | 9 | 2 | 6 | 10 | 0 | 1.71 | .324 | |
| Manuel Corpas | CHC | 0.93 | 0 | 0 | 0 | 1 | 8 | 0 | 0 | 0 | 9.2 | 4 | 1 | 1 | 1 | 3 | 7 | 0 | 0.72 | .129 | |
| Rhiner Cruz | HOU | 7.33 | 1 | 0 | 0 | 1 | 21 | 0 | 0 | 0 | 23.1 | 30 | 19 | 19 | 5 | 11 | 19 | 0 | 1.76 | .316 | |
| Steve Delabar | SEA | 4.78 | 1 | 1 | 0 | 1 | 26 | 0 | 0 | 0 | 26.1 | 18 | 14 | 14 | 7 | 8 | 34 | 0 | 0.99 | .188 | |
| Sean Doolittle | OAK | 5.14 | 1 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 7 | 7 | 4 | 4 | 0 | 2 | 14 | 0 | 1.29 | .269 | |
| Mike Dunn | MIA | 8.49 | 0 | 0 | 0 | 1 | 14 | 0 | 0 | 0 | 11.2 | 16 | 12 | 11 | 0 | 10 | 19 | 0 | 2.23 | .314 | |
| Tom Gorzelanny | WAS | 3.55 | 2 | 1 | 1 | 1 | 20 | 0 | 0 | 0 | 33 | 31 | 14 | 13 | 4 | 11 | 28 | 0 | 1.27 | .242 | |
| LaTroy Hawkins | LAA | 0.66 | 1 | 1 | 1 | 1 | 16 | 0 | 0 | 0 | 13.2 | 13 | 2 | 1 | 0 | 6 | 6 | 0 | 1.39 | .260 | |
| Livan Hernandez | ATL | 4.94 | 1 | 1 | 1 | 1 | 18 | 0 | 0 | 0 | 31 | 40 | 17 | 17 | 5 | 8 | 19 | 0 | 1.55 | .331 | |
| Alex Hinshaw | SD | 4.30 | 0 | 1 | 0 | 1 | 15 | 0 | 0 | 0 | 14.2 | 12 | 7 | 7 | 2 | 10 | 19 | 0 | 1.50 | .214 | |
| Jason Isringhausen | LAA | 1.73 | 2 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 26 | 17 | 5 | 5 | 1 | 12 | 17 | 0 | 1.12 | .179 | |
| Shawn Kelley | SEA | 4.12 | 1 | 2 | 0 | 1 | 21 | 0 | 0 | 0 | 19.2 | 25 | 13 | 9 | 3 | 7 | 22 | 0 | 1.63 | .305 | |
| Kyle Kendrick | PHI | 5.29 | 2 | 7 | 0 | 1 | 15 | 10 | 1 | 1 | 63 | 74 | 41 | 37 | 8 | 23 | 40 | 4 | 1.54 | .301 | |
| Matt Lindstrom | BAL | 1.29 | 0 | 0 | 0 | 1 | 13 | 0 | 0 | 0 | 14 | 12 | 5 | 2 | 0 | 4 | 14 | 0 | 1.14 | .226 | |
| Boone Logan | NYY | 2.81 | 1 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 25.2 | 23 | 8 | 8 | 2 | 10 | 33 | 0 | 1.29 | .240 | |
| Wilton Lopez | HOU | 2.51 | 3 | 0 | 0 | 1 | 32 | 0 | 0 | 0 | 32.1 | 27 | 9 | 9 | 3 | 4 | 26 | 0 | 0.96 | .237 | |
| Cristhian Martinez | ATL | 4.41 | 3 | 1 | 1 | 1 | 24 | 0 | 0 | 0 | 34.2 | 37 | 17 | 17 | 4 | 7 | 34 | 0 | 1.27 | .274 | |
| Mark Melancon | BOS | 15.43 | 0 | 2 | 0 | 1 | 9 | 0 | 0 | 0 | 7 | 13 | 12 | 12 | 5 | 4 | 4 | 0 | 2.43 | .406 | |
| Jose Mijares | KC | 1.95 | 2 | 1 | 0 | 1 | 35 | 0 | 0 | 0 | 27.2 | 26 | 7 | 6 | 2 | 5 | 27 | 0 | 1.12 | .248 | |
| Miles Mikolas | SD | 3.29 | 1 | 1 | 0 | 1 | 13 | 0 | 0 | 0 | 13.2 | 11 | 6 | 5 | 1 | 9 | 12 | 0 | 1.46 | .224 | |
| Darren O'Day | BAL | 1.72 | 4 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 31.1 | 21 | 6 | 6 | 3 | 4 | 32 | 0 | 0.80 | .189 | |
| Will Ohman | CWS | 5.70 | 0 | 2 | 0 | 1 | 29 | 0 | 0 | 0 | 23.2 | 18 | 15 | 15 | 5 | 4 | 11 | 0 | 0.93 | .205 | |
| Darren Oliver | TOR | 1.48 | 1 | 2 | 0 | 1 | 28 | 0 | 0 | 0 | 24.1 | 16 | 4 | 4 | 1 | 7 | 26 | 0 | 0.95 | .190 | |
| Jose Ortega | DET | 0.00 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0.1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 | .667 | |
| Manny Parra | MIL | 4.68 | 0 | 1 | 0 | 1 | 27 | 0 | 0 | 0 | 32.2 | 35 | 20 | 17 | 1 | 13 | 35 | 0 | 1.47 | .269 | |
| Troy Patton | BAL | 3.45 | 1 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 31.1 | 26 | 12 | 12 | 3 | 6 | 28 | 0 | 1.02 | .222 | |
| Vinnie Pestano | CLE | 1.86 | 3 | 0 | 0 | 1 | 31 | 0 | 0 | 0 | 29 | 16 | 6 | 6 | 2 | 13 | 35 | 0 | 1.00 | .157 | |
| Luke Putkonen | DET | 8.59 | 0 | 2 | 0 | 1 | 6 | 0 | 0 | 0 | 7.1 | 14 | 7 | 7 | 0 | 5 | 6 | 0 | 2.59 | .400 | |
| Chris Resop | PIT | 3.82 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 35.1 | 43 | 17 | 15 | 5 | 15 | 25 | 0 | 1.64 | .285 | |
| Fernando Rodriguez | HOU | 5.93 | 1 | 7 | 0 | 1 | 31 | 0 | 0 | 0 | 27.1 | 25 | 20 | 18 | 4 | 15 | 27 | 0 | 1.46 | .238 | |
| James Russell | CHC | 2.53 | 2 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 32 | 31 | 11 | 9 | 3 | 14 | 26 | 0 | 1.41 | .252 | |
| Chris Sale | CWS | 2.24 | 8 | 2 | 0 | 1 | 14 | 13 | 1 | 0 | 88.1 | 62 | 23 | 22 | 4 | 23 | 89 | 9 | 0.96 | .194 | |
| Michael Schwimer | PHI | 5.14 | 0 | 1 | 0 | 1 | 13 | 0 | 0 | 0 | 14 | 11 | 8 | 8 | 2 | 8 | 10 | 0 | 1.36 | .224 | |
| Evan Scribner | OAK | 0.00 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 4.1 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 0.23 | .000 | |
| Tony Sipp | CLE | 6.95 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 22 | 24 | 18 | 17 | 5 | 10 | 25 | 0 | 1.55 | .273 | |
| Joe Smith | CLE | 3.56 | 5 | 1 | 0 | 1 | 32 | 0 | 0 | 0 | 30.1 | 26 | 13 | 12 | 2 | 13 | 26 | 0 | 1.29 | .236 | |
| Craig Stammen | WAS | 1.50 | 3 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 36 | 26 | 7 | 6 | 2 | 14 | 38 | 0 | 1.11 | .197 | |
| Hisanori Takahashi | LAA | 4.32 | 0 | 2 | 0 | 1 | 24 | 0 | 0 | 0 | 25 | 23 | 12 | 12 | 3 | 6 | 21 | 0 | 1.16 | .247 | |
| Junichi Tazawa | BOS | 0.00 | 0 | 0 | 1 | 1 | 5 | 0 | 0 | 0 | 6.1 | 5 | 0 | 0 | 0 | 0 | 4 | 0 | 0.79 | .200 | |
| Raul Valdes | PHI | 2.13 | 2 | 0 | 0 | 1 | 11 | 0 | 0 | 0 | 12.2 | 7 | 3 | 3 | 1 | 1 | 13 | 0 | 0.63 | .163 | |
| Cory Wade | NYY | 3.38 | 0 | 1 | 0 | 1 | 30 | 0 | 0 | 0 | 29.1 | 26 | 12 | 11 | 4 | 6 | 30 | 0 | 1.09 | .232 | |
| Tony Watson | PIT | 3.57 | 4 | 0 | 0 | 1 | 31 | 0 | 0 | 0 | 22.2 | 16 | 10 | 9 | 3 | 10 | 19 | 0 | 1.15 | .203 | |
| Randy Wells | CHC | 4.91 | 1 | 2 | 0 | 1 | 11 | 3 | 0 | 0 | 25.2 | 29 | 15 | 14 | 1 | 20 | 11 | 0 | 1.91 | .296 | |
| Brian Wilson | SF | 9.00 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 2 | 4 | 2 | 2 | 0 | 2 | 2 | 0 | 3.00 | .400 |