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| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Chris Perez | CLE | 2.54 | 0 | 1 | 23 | 24 | 30 | 0 | 0 | 0 | 28.1 | 21 | 8 | 8 | 0 | 7 | 28 | 0 | 0.99 | .198 |
| 2 | Jim Johnson | BAL | 1.14 | 1 | 0 | 21 | 22 | 31 | 0 | 0 | 0 | 31.2 | 15 | 4 | 4 | 3 | 6 | 19 | 0 | 0.66 | .140 |
| Craig Kimbrel | ATL | 1.33 | 0 | 0 | 21 | 22 | 27 | 0 | 0 | 0 | 27 | 12 | 4 | 4 | 0 | 10 | 44 | 0 | 0.81 | .129 | |
| 4 | Santiago Casilla | SF | 1.59 | 1 | 2 | 20 | 21 | 31 | 0 | 0 | 0 | 28.1 | 21 | 7 | 5 | 4 | 8 | 25 | 0 | 1.02 | .191 |
| Fernando Rodney | TB | 1.10 | 2 | 1 | 20 | 21 | 34 | 0 | 0 | 0 | 32.2 | 20 | 6 | 4 | 1 | 5 | 31 | 0 | 0.77 | .174 | |
| 6 | Alfredo Aceves | BOS | 4.54 | 0 | 4 | 18 | 21 | 34 | 0 | 0 | 0 | 35.2 | 31 | 18 | 18 | 3 | 13 | 39 | 0 | 1.23 | .235 |
| Jonathan Broxton | KC | 1.57 | 1 | 1 | 18 | 21 | 28 | 0 | 0 | 0 | 28.2 | 27 | 7 | 5 | 1 | 10 | 22 | 0 | 1.29 | .255 | |
| Frank Francisco | NYM | 4.97 | 1 | 3 | 18 | 21 | 31 | 0 | 0 | 0 | 29 | 32 | 17 | 16 | 3 | 14 | 31 | 0 | 1.59 | .264 | |
| Joel Hanrahan | PIT | 2.33 | 3 | 0 | 18 | 20 | 28 | 0 | 0 | 0 | 27 | 15 | 7 | 7 | 4 | 13 | 33 | 0 | 1.04 | .160 | |
| 10 | Jonathan Papelbon | PHI | 2.28 | 1 | 2 | 17 | 17 | 28 | 0 | 0 | 0 | 27.2 | 21 | 7 | 7 | 3 | 6 | 33 | 0 | 0.98 | .206 |
| 11 | Brett Myers | HOU | 3.86 | 0 | 2 | 16 | 17 | 26 | 0 | 0 | 0 | 23.1 | 23 | 10 | 10 | 3 | 4 | 16 | 0 | 1.16 | .258 |
| Joe Nathan | TEX | 1.52 | 0 | 2 | 16 | 17 | 30 | 0 | 0 | 0 | 29.2 | 23 | 6 | 5 | 2 | 2 | 36 | 0 | 0.84 | .213 | |
| 13 | Heath Bell | MIA | 5.47 | 2 | 3 | 14 | 18 | 31 | 0 | 0 | 0 | 26.1 | 30 | 18 | 16 | 1 | 16 | 26 | 0 | 1.75 | .286 |
| Matt Capps | MIN | 3.55 | 1 | 4 | 14 | 15 | 26 | 0 | 0 | 0 | 25.1 | 23 | 10 | 10 | 4 | 3 | 15 | 0 | 1.03 | .235 | |
| Jason Motte | STL | 3.41 | 3 | 3 | 14 | 18 | 28 | 0 | 0 | 0 | 31.2 | 21 | 12 | 12 | 5 | 11 | 31 | 0 | 1.01 | .194 | |
| 16 | John Axford | MIL | 5.08 | 1 | 4 | 13 | 17 | 30 | 0 | 0 | 0 | 28.1 | 26 | 20 | 16 | 3 | 18 | 39 | 0 | 1.55 | .230 |
| J.J. Putz | ARI | 5.73 | 1 | 4 | 13 | 16 | 23 | 0 | 0 | 0 | 22 | 23 | 14 | 14 | 4 | 5 | 24 | 0 | 1.27 | .261 | |
| Rafael Soriano | NYY | 1.78 | 2 | 0 | 13 | 14 | 27 | 0 | 0 | 0 | 25.1 | 26 | 5 | 5 | 0 | 10 | 22 | 0 | 1.42 | .257 | |
| Jose Valverde | DET | 4.18 | 3 | 2 | 13 | 16 | 29 | 0 | 0 | 0 | 28 | 25 | 18 | 13 | 2 | 17 | 19 | 0 | 1.50 | .238 | |
| 20 | Rafael Betancourt | COL | 3.16 | 1 | 3 | 11 | 14 | 26 | 0 | 0 | 0 | 25.2 | 20 | 10 | 9 | 2 | 7 | 26 | 0 | 1.05 | .211 |
| Tyler Clippard | WAS | 2.01 | 1 | 2 | 11 | 12 | 32 | 0 | 0 | 0 | 31.1 | 15 | 8 | 7 | 0 | 14 | 38 | 0 | 0.93 | .140 | |
| Kenley Jansen | LAD | 2.51 | 4 | 2 | 11 | 14 | 32 | 0 | 0 | 0 | 32.1 | 17 | 9 | 9 | 4 | 12 | 51 | 0 | 0.90 | .150 | |
| 23 | Brandon League | SEA | 3.77 | 0 | 4 | 9 | 13 | 31 | 0 | 0 | 0 | 31 | 33 | 14 | 13 | 1 | 15 | 20 | 0 | 1.55 | .280 |
| Sean Marshall | CIN | 2.83 | 1 | 3 | 9 | 10 | 33 | 0 | 0 | 0 | 28.2 | 28 | 9 | 9 | 2 | 6 | 36 | 0 | 1.19 | .246 | |
| Henry Rodriguez | WAS | 5.14 | 1 | 3 | 9 | 12 | 24 | 0 | 0 | 0 | 21 | 13 | 13 | 12 | 3 | 14 | 23 | 0 | 1.29 | .176 | |
| Huston Street | SD | 1.69 | 1 | 0 | 9 | 9 | 17 | 0 | 0 | 0 | 16 | 8 | 3 | 3 | 0 | 5 | 20 | 0 | 0.81 | .145 | |
| 27 | Aroldis Chapman | CIN | 1.57 | 4 | 3 | 8 | 11 | 30 | 0 | 0 | 0 | 34.1 | 14 | 7 | 6 | 2 | 11 | 59 | 0 | 0.73 | .119 |
| Ernesto Frieri | LAA | 0.84 | 1 | 0 | 8 | 8 | 32 | 0 | 0 | 0 | 32.1 | 12 | 5 | 3 | 2 | 18 | 54 | 0 | 0.93 | .112 | |
| Javy Guerra | LAD | 3.38 | 2 | 3 | 8 | 11 | 27 | 0 | 0 | 0 | 24 | 26 | 9 | 9 | 0 | 10 | 20 | 0 | 1.50 | .289 | |
| Addison Reed | CWS | 4.18 | 1 | 1 | 8 | 9 | 27 | 0 | 0 | 0 | 23.2 | 20 | 11 | 11 | 1 | 9 | 26 | 0 | 1.23 | .222 | |
| 31 | Grant Balfour | OAK | 2.75 | 1 | 1 | 7 | 9 | 35 | 0 | 0 | 0 | 36 | 23 | 11 | 11 | 3 | 15 | 29 | 0 | 1.06 | .185 |
| Casey Janssen | TOR | 2.70 | 1 | 1 | 7 | 8 | 26 | 0 | 0 | 0 | 26.2 | 21 | 8 | 8 | 4 | 5 | 23 | 0 | 0.98 | .216 | |
| 33 | Scott Downs | LAA | 0.37 | 0 | 0 | 6 | 8 | 27 | 0 | 0 | 0 | 24.1 | 20 | 2 | 1 | 0 | 5 | 16 | 0 | 1.03 | .222 |
| 34 | Brian Fuentes | OAK | 5.79 | 2 | 2 | 5 | 8 | 24 | 0 | 0 | 0 | 23.1 | 26 | 15 | 15 | 4 | 6 | 17 | 0 | 1.37 | .277 |
| Mariano Rivera | NYY | 2.16 | 1 | 1 | 5 | 6 | 9 | 0 | 0 | 0 | 8.1 | 6 | 2 | 2 | 0 | 2 | 8 | 0 | 0.96 | .200 | |
| Dale Thayer | SD | 6.16 | 0 | 2 | 5 | 6 | 21 | 0 | 0 | 0 | 19 | 24 | 13 | 13 | 3 | 4 | 16 | 0 | 1.47 | .320 | |
| Tom Wilhelmsen | SEA | 3.00 | 3 | 1 | 5 | 6 | 32 | 0 | 0 | 0 | 36 | 29 | 14 | 12 | 3 | 11 | 44 | 0 | 1.11 | .216 | |
| 38 | Ryan Cook | OAK | 1.71 | 2 | 2 | 4 | 6 | 31 | 0 | 0 | 0 | 31.2 | 11 | 6 | 6 | 0 | 20 | 33 | 0 | 0.98 | .109 |
| Rafael Dolis | CHC | 5.68 | 2 | 4 | 4 | 6 | 23 | 0 | 0 | 0 | 25.1 | 21 | 18 | 16 | 2 | 17 | 11 | 0 | 1.50 | .236 | |
| Carlos Marmol | CHC | 5.49 | 1 | 2 | 4 | 6 | 24 | 0 | 0 | 0 | 19.2 | 15 | 14 | 12 | 2 | 23 | 22 | 0 | 1.93 | .200 | |
| Hector Santiago | CWS | 4.15 | 1 | 1 | 4 | 6 | 23 | 0 | 0 | 0 | 26 | 25 | 12 | 12 | 6 | 11 | 30 | 0 | 1.38 | .245 | |
| 42 | Juan Cruz | PIT | 2.66 | 1 | 1 | 3 | 3 | 28 | 0 | 0 | 0 | 23.2 | 28 | 8 | 7 | 2 | 11 | 25 | 0 | 1.65 | .308 |
| Sergio Romo | SF | 0.93 | 2 | 1 | 3 | 3 | 26 | 0 | 0 | 0 | 19.1 | 10 | 2 | 2 | 1 | 5 | 25 | 0 | 0.78 | .149 | |
| Pedro Strop | BAL | 1.38 | 3 | 2 | 3 | 6 | 29 | 0 | 0 | 0 | 32.2 | 19 | 5 | 5 | 1 | 18 | 28 | 0 | 1.13 | .174 | |
| 45 | Sean Burnett | WAS | 1.08 | 0 | 0 | 2 | 2 | 30 | 0 | 0 | 0 | 25 | 16 | 3 | 3 | 1 | 6 | 25 | 0 | 0.88 | .182 |
| Francisco Cordero | TOR | 5.08 | 2 | 4 | 2 | 5 | 33 | 0 | 0 | 0 | 28.1 | 36 | 18 | 16 | 5 | 13 | 21 | 0 | 1.73 | .319 | |
| David Hernandez | ARI | 2.90 | 0 | 1 | 2 | 6 | 33 | 0 | 0 | 0 | 31 | 22 | 12 | 10 | 2 | 12 | 45 | 0 | 1.10 | .193 | |
| Hisashi Iwakuma | SEA | 5.06 | 1 | 0 | 2 | 2 | 13 | 0 | 0 | 0 | 26.2 | 27 | 15 | 15 | 5 | 13 | 20 | 0 | 1.50 | .270 | |
| Brad Lidge | WAS | 9.64 | 0 | 1 | 2 | 4 | 11 | 0 | 0 | 0 | 9.1 | 12 | 10 | 10 | 1 | 11 | 10 | 0 | 2.46 | .308 | |
| Edward Mujica | MIA | 4.22 | 0 | 3 | 2 | 5 | 31 | 0 | 0 | 0 | 32 | 28 | 17 | 15 | 4 | 8 | 16 | 0 | 1.13 | .230 | |
| Logan Ondrusek | CIN | 3.00 | 3 | 1 | 2 | 3 | 32 | 0 | 0 | 0 | 27 | 22 | 9 | 9 | 3 | 13 | 17 | 0 | 1.30 | .224 | |
| Joel Peralta | TB | 4.20 | 0 | 3 | 2 | 5 | 36 | 0 | 0 | 0 | 30 | 23 | 14 | 14 | 5 | 8 | 36 | 0 | 1.03 | .207 | |
| Glen Perkins | MIN | 2.93 | 1 | 1 | 2 | 4 | 32 | 0 | 0 | 0 | 30.2 | 28 | 12 | 10 | 3 | 13 | 40 | 0 | 1.34 | .248 | |
| Sergio Santos | TOR | 9.00 | 0 | 1 | 2 | 4 | 6 | 0 | 0 | 0 | 5 | 6 | 5 | 5 | 1 | 4 | 4 | 0 | 2.00 | .316 | |
| Bryan Shaw | ARI | 3.10 | 1 | 3 | 2 | 3 | 32 | 0 | 0 | 0 | 29 | 25 | 11 | 10 | 3 | 10 | 20 | 0 | 1.21 | .243 | |
| 56 | Mike Adams | TEX | 3.00 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 24 | 25 | 10 | 8 | 1 | 5 | 19 | 0 | 1.25 | .263 |
| Jeremy Affeldt | SF | 2.77 | 0 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 26 | 25 | 12 | 8 | 1 | 8 | 23 | 0 | 1.27 | .248 | |
| Jose Arredondo | CIN | 2.05 | 4 | 1 | 1 | 2 | 31 | 0 | 0 | 0 | 30.2 | 16 | 7 | 7 | 3 | 16 | 34 | 0 | 1.04 | .152 | |
| Luis Ayala | BAL | 1.95 | 2 | 1 | 1 | 3 | 28 | 0 | 0 | 0 | 32.1 | 29 | 9 | 7 | 2 | 6 | 22 | 0 | 1.08 | .230 | |
| Joaquin Benoit | DET | 1.93 | 1 | 1 | 1 | 2 | 33 | 0 | 0 | 0 | 32.2 | 26 | 9 | 7 | 1 | 14 | 44 | 0 | 1.22 | .222 | |
| Shawn Camp | CHC | 3.35 | 2 | 4 | 1 | 3 | 35 | 0 | 0 | 0 | 37.2 | 36 | 14 | 14 | 3 | 10 | 30 | 0 | 1.22 | .250 | |
| Xavier Cedeno | HOU | 3.12 | 0 | 0 | 1 | 1 | 10 | 0 | 0 | 0 | 8.2 | 9 | 3 | 3 | 1 | 4 | 7 | 0 | 1.50 | .273 | |
| Tyler Chatwood | COL | 5.63 | 1 | 0 | 1 | 1 | 4 | 0 | 0 | 0 | 8 | 11 | 5 | 5 | 1 | 1 | 7 | 0 | 1.50 | .333 | |
| Randy Choate | MIA | 2.49 | 0 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 21.2 | 13 | 10 | 6 | 0 | 8 | 19 | 0 | 0.97 | .169 | |
| Steve Cishek | MIA | 2.45 | 4 | 0 | 1 | 4 | 30 | 0 | 0 | 0 | 29.1 | 24 | 10 | 8 | 2 | 15 | 29 | 0 | 1.33 | .229 | |
| Phil Coke | DET | 3.45 | 1 | 3 | 1 | 2 | 33 | 0 | 0 | 0 | 31.1 | 37 | 15 | 12 | 1 | 8 | 29 | 0 | 1.44 | .303 | |
| Aaron Crow | KC | 2.73 | 0 | 1 | 1 | 3 | 33 | 0 | 0 | 0 | 29.2 | 23 | 10 | 9 | 1 | 12 | 28 | 0 | 1.18 | .215 | |
| Octavio Dotel | DET | 4.19 | 1 | 2 | 1 | 3 | 22 | 0 | 0 | 0 | 19.1 | 14 | 9 | 9 | 2 | 6 | 29 | 0 | 1.03 | .194 | |
| Tom Gorzelanny | WAS | 3.55 | 2 | 1 | 1 | 1 | 20 | 0 | 0 | 0 | 33 | 31 | 14 | 13 | 4 | 11 | 28 | 0 | 1.27 | .242 | |
| Jason Grilli | PIT | 1.95 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 27.2 | 15 | 7 | 6 | 3 | 15 | 43 | 0 | 1.08 | .155 | |
| Nick Hagadone | CLE | 4.91 | 1 | 0 | 1 | 2 | 23 | 0 | 0 | 0 | 22 | 18 | 12 | 12 | 3 | 11 | 23 | 0 | 1.32 | .217 | |
| LaTroy Hawkins | LAA | 0.66 | 1 | 1 | 1 | 1 | 16 | 0 | 0 | 0 | 13.2 | 13 | 2 | 1 | 0 | 6 | 6 | 0 | 1.39 | .260 | |
| Clay Hensley | SF | 3.62 | 3 | 3 | 1 | 2 | 31 | 0 | 0 | 0 | 27.1 | 24 | 15 | 11 | 1 | 19 | 24 | 0 | 1.57 | .235 | |
| Livan Hernandez | ATL | 4.94 | 1 | 1 | 1 | 1 | 18 | 0 | 0 | 0 | 31 | 40 | 17 | 17 | 5 | 8 | 19 | 0 | 1.55 | .331 | |
| Boone Logan | NYY | 2.81 | 1 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 25.2 | 23 | 8 | 8 | 2 | 10 | 33 | 0 | 1.29 | .240 | |
| Javier Lopez | SF | 2.93 | 3 | 0 | 1 | 3 | 31 | 0 | 0 | 0 | 15.1 | 19 | 7 | 5 | 0 | 8 | 13 | 0 | 1.76 | .297 | |
| Cristhian Martinez | ATL | 4.41 | 3 | 1 | 1 | 1 | 24 | 0 | 0 | 0 | 34.2 | 37 | 17 | 17 | 4 | 7 | 34 | 0 | 1.27 | .274 | |
| Kris Medlen | ATL | 3.34 | 1 | 1 | 1 | 2 | 24 | 0 | 0 | 0 | 32.1 | 31 | 12 | 12 | 1 | 8 | 18 | 0 | 1.21 | .261 | |
| Jordan Norberto | OAK | 3.91 | 0 | 1 | 1 | 2 | 21 | 0 | 0 | 0 | 25.1 | 16 | 11 | 11 | 1 | 12 | 18 | 0 | 1.11 | .184 | |
| Alexi Ogando | TEX | 2.08 | 1 | 0 | 1 | 3 | 28 | 1 | 0 | 0 | 34.2 | 21 | 8 | 8 | 2 | 7 | 35 | 0 | 0.81 | .175 | |
| Vicente Padilla | BOS | 4.15 | 1 | 0 | 1 | 2 | 26 | 0 | 0 | 0 | 26 | 29 | 13 | 12 | 2 | 6 | 25 | 0 | 1.35 | .282 | |
| Ramon Ramirez | NYM | 4.78 | 2 | 1 | 1 | 3 | 22 | 0 | 0 | 0 | 26.1 | 29 | 15 | 14 | 2 | 11 | 25 | 0 | 1.52 | .290 | |
| Jon Rauch | NYM | 4.28 | 3 | 6 | 1 | 4 | 32 | 0 | 0 | 0 | 27.1 | 27 | 14 | 13 | 2 | 5 | 18 | 0 | 1.17 | .252 | |
| Chris Resop | PIT | 3.82 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 35.1 | 43 | 17 | 15 | 5 | 15 | 25 | 0 | 1.64 | .285 | |
| David Robertson | NYY | 2.76 | 0 | 1 | 1 | 2 | 17 | 0 | 0 | 0 | 16.1 | 14 | 5 | 5 | 1 | 6 | 26 | 0 | 1.22 | .230 | |
| Francisco Rodriguez | MIL | 3.90 | 0 | 4 | 1 | 3 | 35 | 0 | 0 | 0 | 32.1 | 35 | 15 | 14 | 3 | 11 | 30 | 0 | 1.42 | .278 | |
| James Russell | CHC | 2.53 | 2 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 32 | 31 | 11 | 9 | 3 | 14 | 26 | 0 | 1.41 | .252 | |
| Evan Scribner | OAK | 0.00 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 4.1 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 0.23 | .000 | |
| Tony Sipp | CLE | 6.95 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 22 | 24 | 18 | 17 | 5 | 10 | 25 | 0 | 1.55 | .273 | |
| Junichi Tazawa | BOS | 0.00 | 0 | 0 | 1 | 1 | 5 | 0 | 0 | 0 | 6.1 | 5 | 0 | 0 | 0 | 0 | 4 | 0 | 0.79 | .200 | |
| Matt Thornton | CWS | 3.23 | 2 | 5 | 1 | 4 | 35 | 0 | 0 | 0 | 30.2 | 30 | 12 | 11 | 2 | 9 | 27 | 0 | 1.27 | .254 | |
| Jose Veras | MIL | 3.90 | 3 | 2 | 1 | 2 | 32 | 0 | 0 | 0 | 30 | 30 | 14 | 13 | 1 | 19 | 33 | 0 | 1.63 | .252 | |
| Jordan Walden | LAA | 2.86 | 2 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 22 | 18 | 7 | 7 | 1 | 13 | 25 | 0 | 1.41 | .214 | |
| Brian Wilson | SF | 9.00 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 2 | 4 | 2 | 2 | 0 | 2 | 2 | 0 | 3.00 | .400 |