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| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Chris Perez | CLE | 2.54 | 0 | 1 | 23 | 24 | 30 | 0 | 0 | 0 | 28.1 | 21 | 8 | 8 | 0 | 7 | 28 | 0 | 0.99 | .198 |
| 2 | Jim Johnson | BAL | 1.14 | 1 | 0 | 21 | 22 | 31 | 0 | 0 | 0 | 31.2 | 15 | 4 | 4 | 3 | 6 | 19 | 0 | 0.66 | .140 |
| 3 | Alfredo Aceves | BOS | 4.54 | 0 | 4 | 18 | 21 | 34 | 0 | 0 | 0 | 35.2 | 31 | 18 | 18 | 3 | 13 | 39 | 0 | 1.23 | .235 |
| Jonathan Broxton | KC | 1.57 | 1 | 1 | 18 | 21 | 28 | 0 | 0 | 0 | 28.2 | 27 | 7 | 5 | 1 | 10 | 22 | 0 | 1.29 | .255 | |
| Fernando Rodney | TB | 1.10 | 2 | 1 | 20 | 21 | 34 | 0 | 0 | 0 | 32.2 | 20 | 6 | 4 | 1 | 5 | 31 | 0 | 0.77 | .174 | |
| 6 | Joe Nathan | TEX | 1.52 | 0 | 2 | 16 | 17 | 30 | 0 | 0 | 0 | 29.2 | 23 | 6 | 5 | 2 | 2 | 36 | 0 | 0.84 | .213 |
| 7 | Jose Valverde | DET | 4.18 | 3 | 2 | 13 | 16 | 29 | 0 | 0 | 0 | 28 | 25 | 18 | 13 | 2 | 17 | 19 | 0 | 1.50 | .238 |
| 8 | Matt Capps | MIN | 3.55 | 1 | 4 | 14 | 15 | 26 | 0 | 0 | 0 | 25.1 | 23 | 10 | 10 | 4 | 3 | 15 | 0 | 1.03 | .235 |
| 9 | Rafael Soriano | NYY | 1.78 | 2 | 0 | 13 | 14 | 27 | 0 | 0 | 0 | 25.1 | 26 | 5 | 5 | 0 | 10 | 22 | 0 | 1.42 | .257 |
| 10 | Brandon League | SEA | 3.77 | 0 | 4 | 9 | 13 | 31 | 0 | 0 | 0 | 31 | 33 | 14 | 13 | 1 | 15 | 20 | 0 | 1.55 | .280 |
| 11 | Grant Balfour | OAK | 2.75 | 1 | 1 | 7 | 9 | 35 | 0 | 0 | 0 | 36 | 23 | 11 | 11 | 3 | 15 | 29 | 0 | 1.06 | .185 |
| Addison Reed | CWS | 4.18 | 1 | 1 | 8 | 9 | 27 | 0 | 0 | 0 | 23.2 | 20 | 11 | 11 | 1 | 9 | 26 | 0 | 1.23 | .222 | |
| 13 | Scott Downs | LAA | 0.37 | 0 | 0 | 6 | 8 | 27 | 0 | 0 | 0 | 24.1 | 20 | 2 | 1 | 0 | 5 | 16 | 0 | 1.03 | .222 |
| Ernesto Frieri | LAA | 0.84 | 1 | 0 | 8 | 8 | 32 | 0 | 0 | 0 | 32.1 | 12 | 5 | 3 | 2 | 18 | 54 | 0 | 0.93 | .112 | |
| Brian Fuentes | OAK | 5.79 | 2 | 2 | 5 | 8 | 24 | 0 | 0 | 0 | 23.1 | 26 | 15 | 15 | 4 | 6 | 17 | 0 | 1.37 | .277 | |
| Casey Janssen | TOR | 2.70 | 1 | 1 | 7 | 8 | 26 | 0 | 0 | 0 | 26.2 | 21 | 8 | 8 | 4 | 5 | 23 | 0 | 0.98 | .216 | |
| 17 | Ryan Cook | OAK | 1.71 | 2 | 2 | 4 | 6 | 31 | 0 | 0 | 0 | 31.2 | 11 | 6 | 6 | 0 | 20 | 33 | 0 | 0.98 | .109 |
| Mariano Rivera | NYY | 2.16 | 1 | 1 | 5 | 6 | 9 | 0 | 0 | 0 | 8.1 | 6 | 2 | 2 | 0 | 2 | 8 | 0 | 0.96 | .200 | |
| Hector Santiago | CWS | 4.15 | 1 | 1 | 4 | 6 | 23 | 0 | 0 | 0 | 26 | 25 | 12 | 12 | 6 | 11 | 30 | 0 | 1.38 | .245 | |
| Pedro Strop | BAL | 1.38 | 3 | 2 | 3 | 6 | 29 | 0 | 0 | 0 | 32.2 | 19 | 5 | 5 | 1 | 18 | 28 | 0 | 1.13 | .174 | |
| Tom Wilhelmsen | SEA | 3.00 | 3 | 1 | 5 | 6 | 32 | 0 | 0 | 0 | 36 | 29 | 14 | 12 | 3 | 11 | 44 | 0 | 1.11 | .216 | |
| 22 | Francisco Cordero | TOR | 5.08 | 2 | 4 | 2 | 5 | 33 | 0 | 0 | 0 | 28.1 | 36 | 18 | 16 | 5 | 13 | 21 | 0 | 1.73 | .319 |
| Joel Peralta | TB | 4.20 | 0 | 3 | 2 | 5 | 36 | 0 | 0 | 0 | 30 | 23 | 14 | 14 | 5 | 8 | 36 | 0 | 1.03 | .207 | |
| 24 | Glen Perkins | MIN | 2.93 | 1 | 1 | 2 | 4 | 32 | 0 | 0 | 0 | 30.2 | 28 | 12 | 10 | 3 | 13 | 40 | 0 | 1.34 | .248 |
| Sergio Santos | TOR | 9.00 | 0 | 1 | 2 | 4 | 6 | 0 | 0 | 0 | 5 | 6 | 5 | 5 | 1 | 4 | 4 | 0 | 2.00 | .316 | |
| Matt Thornton | CWS | 3.23 | 2 | 5 | 1 | 4 | 35 | 0 | 0 | 0 | 30.2 | 30 | 12 | 11 | 2 | 9 | 27 | 0 | 1.27 | .254 | |
| 27 | Matt Albers | BOS | 1.88 | 2 | 0 | 0 | 3 | 26 | 0 | 0 | 0 | 28.2 | 21 | 10 | 6 | 3 | 7 | 19 | 0 | 0.98 | .200 |
| Luis Ayala | BAL | 1.95 | 2 | 1 | 1 | 3 | 28 | 0 | 0 | 0 | 32.1 | 29 | 9 | 7 | 2 | 6 | 22 | 0 | 1.08 | .230 | |
| Jesse Crain | CWS | 2.45 | 1 | 1 | 0 | 3 | 23 | 0 | 0 | 0 | 22 | 16 | 7 | 6 | 2 | 8 | 26 | 0 | 1.09 | .195 | |
| Aaron Crow | KC | 2.73 | 0 | 1 | 1 | 3 | 33 | 0 | 0 | 0 | 29.2 | 23 | 10 | 9 | 1 | 12 | 28 | 0 | 1.18 | .215 | |
| Octavio Dotel | DET | 4.19 | 1 | 2 | 1 | 3 | 22 | 0 | 0 | 0 | 19.1 | 14 | 9 | 9 | 2 | 6 | 29 | 0 | 1.03 | .194 | |
| Alexi Ogando | TEX | 2.08 | 1 | 0 | 1 | 3 | 28 | 1 | 0 | 0 | 34.2 | 21 | 8 | 8 | 2 | 7 | 35 | 0 | 0.81 | .175 | |
| 33 | Mike Adams | TEX | 3.00 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 24 | 25 | 10 | 8 | 1 | 5 | 19 | 0 | 1.25 | .263 |
| Joaquin Benoit | DET | 1.93 | 1 | 1 | 1 | 2 | 33 | 0 | 0 | 0 | 32.2 | 26 | 9 | 7 | 1 | 14 | 44 | 0 | 1.22 | .222 | |
| Bobby Cassevah | LAA | 7.20 | 1 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 5 | 5 | 4 | 4 | 2 | 6 | 2 | 0 | 2.20 | .263 | |
| Phil Coke | DET | 3.45 | 1 | 3 | 1 | 2 | 33 | 0 | 0 | 0 | 31.1 | 37 | 15 | 12 | 1 | 8 | 29 | 0 | 1.44 | .303 | |
| Jason Frasor | TOR | 4.10 | 0 | 1 | 0 | 2 | 31 | 0 | 0 | 0 | 26.1 | 25 | 12 | 12 | 3 | 16 | 35 | 0 | 1.56 | .253 | |
| Nick Hagadone | CLE | 4.91 | 1 | 0 | 1 | 2 | 23 | 0 | 0 | 0 | 22 | 18 | 12 | 12 | 3 | 11 | 23 | 0 | 1.32 | .217 | |
| Greg Holland | KC | 3.75 | 2 | 2 | 0 | 2 | 26 | 0 | 0 | 0 | 24 | 24 | 10 | 10 | 0 | 15 | 34 | 0 | 1.63 | .264 | |
| Hisashi Iwakuma | SEA | 5.06 | 1 | 0 | 2 | 2 | 13 | 0 | 0 | 0 | 26.2 | 27 | 15 | 15 | 5 | 13 | 20 | 0 | 1.50 | .270 | |
| Kevin Jepsen | LAA | 10.29 | 0 | 1 | 0 | 2 | 9 | 0 | 0 | 0 | 7 | 9 | 9 | 8 | 1 | 2 | 4 | 0 | 1.57 | .346 | |
| Jordan Norberto | OAK | 3.91 | 0 | 1 | 1 | 2 | 21 | 0 | 0 | 0 | 25.1 | 16 | 11 | 11 | 1 | 12 | 18 | 0 | 1.11 | .184 | |
| Vicente Padilla | BOS | 4.15 | 1 | 0 | 1 | 2 | 26 | 0 | 0 | 0 | 26 | 29 | 13 | 12 | 2 | 6 | 25 | 0 | 1.35 | .282 | |
| David Robertson | NYY | 2.76 | 0 | 1 | 1 | 2 | 17 | 0 | 0 | 0 | 16.1 | 14 | 5 | 5 | 1 | 6 | 26 | 0 | 1.22 | .230 | |
| Esmil Rogers | CLE | 6.89 | 0 | 2 | 0 | 2 | 27 | 0 | 0 | 0 | 31.1 | 39 | 25 | 24 | 3 | 18 | 36 | 0 | 1.82 | .295 | |
| Jordan Walden | LAA | 2.86 | 2 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 22 | 18 | 7 | 7 | 1 | 13 | 25 | 0 | 1.41 | .214 | |
| 47 | Scott Atchison | BOS | 1.17 | 2 | 0 | 0 | 1 | 29 | 0 | 0 | 0 | 38.1 | 27 | 5 | 5 | 1 | 7 | 29 | 0 | 0.89 | .199 |
| Jared Burton | MIN | 3.10 | 1 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 29 | 22 | 11 | 10 | 4 | 3 | 29 | 0 | 0.86 | .206 | |
| Steve Delabar | SEA | 4.78 | 1 | 1 | 0 | 1 | 26 | 0 | 0 | 0 | 26.1 | 18 | 14 | 14 | 7 | 8 | 34 | 0 | 0.99 | .188 | |
| Sean Doolittle | OAK | 5.14 | 1 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 7 | 7 | 4 | 4 | 0 | 2 | 14 | 0 | 1.29 | .269 | |
| LaTroy Hawkins | LAA | 0.66 | 1 | 1 | 1 | 1 | 16 | 0 | 0 | 0 | 13.2 | 13 | 2 | 1 | 0 | 6 | 6 | 0 | 1.39 | .260 | |
| Jason Isringhausen | LAA | 1.73 | 2 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 26 | 17 | 5 | 5 | 1 | 12 | 17 | 0 | 1.12 | .179 | |
| Shawn Kelley | SEA | 4.12 | 1 | 2 | 0 | 1 | 21 | 0 | 0 | 0 | 19.2 | 25 | 13 | 9 | 3 | 7 | 22 | 0 | 1.63 | .305 | |
| Matt Lindstrom | BAL | 1.29 | 0 | 0 | 0 | 1 | 13 | 0 | 0 | 0 | 14 | 12 | 5 | 2 | 0 | 4 | 14 | 0 | 1.14 | .226 | |
| Boone Logan | NYY | 2.81 | 1 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 25.2 | 23 | 8 | 8 | 2 | 10 | 33 | 0 | 1.29 | .240 | |
| Mark Melancon | BOS | 15.43 | 0 | 2 | 0 | 1 | 9 | 0 | 0 | 0 | 7 | 13 | 12 | 12 | 5 | 4 | 4 | 0 | 2.43 | .406 | |
| Jose Mijares | KC | 1.95 | 2 | 1 | 0 | 1 | 35 | 0 | 0 | 0 | 27.2 | 26 | 7 | 6 | 2 | 5 | 27 | 0 | 1.12 | .248 | |
| Darren O'Day | BAL | 1.72 | 4 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 31.1 | 21 | 6 | 6 | 3 | 4 | 32 | 0 | 0.80 | .189 | |
| Will Ohman | CWS | 5.70 | 0 | 2 | 0 | 1 | 29 | 0 | 0 | 0 | 23.2 | 18 | 15 | 15 | 5 | 4 | 11 | 0 | 0.93 | .205 | |
| Darren Oliver | TOR | 1.48 | 1 | 2 | 0 | 1 | 28 | 0 | 0 | 0 | 24.1 | 16 | 4 | 4 | 1 | 7 | 26 | 0 | 0.95 | .190 | |
| Jose Ortega | DET | 0.00 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0.1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 | .667 | |
| Troy Patton | BAL | 3.45 | 1 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 31.1 | 26 | 12 | 12 | 3 | 6 | 28 | 0 | 1.02 | .222 | |
| Vinnie Pestano | CLE | 1.86 | 3 | 0 | 0 | 1 | 31 | 0 | 0 | 0 | 29 | 16 | 6 | 6 | 2 | 13 | 35 | 0 | 1.00 | .157 | |
| Luke Putkonen | DET | 8.59 | 0 | 2 | 0 | 1 | 6 | 0 | 0 | 0 | 7.1 | 14 | 7 | 7 | 0 | 5 | 6 | 0 | 2.59 | .400 | |
| Chris Sale | CWS | 2.24 | 8 | 2 | 0 | 1 | 14 | 13 | 1 | 0 | 88.1 | 62 | 23 | 22 | 4 | 23 | 89 | 9 | 0.96 | .194 | |
| Evan Scribner | OAK | 0.00 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 4.1 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 0.23 | .000 | |
| Tony Sipp | CLE | 6.95 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 22 | 24 | 18 | 17 | 5 | 10 | 25 | 0 | 1.55 | .273 | |
| Joe Smith | CLE | 3.56 | 5 | 1 | 0 | 1 | 32 | 0 | 0 | 0 | 30.1 | 26 | 13 | 12 | 2 | 13 | 26 | 0 | 1.29 | .236 | |
| Hisanori Takahashi | LAA | 4.32 | 0 | 2 | 0 | 1 | 24 | 0 | 0 | 0 | 25 | 23 | 12 | 12 | 3 | 6 | 21 | 0 | 1.16 | .247 | |
| Junichi Tazawa | BOS | 0.00 | 0 | 0 | 1 | 1 | 5 | 0 | 0 | 0 | 6.1 | 5 | 0 | 0 | 0 | 0 | 4 | 0 | 0.79 | .200 | |
| Cory Wade | NYY | 3.38 | 0 | 1 | 0 | 1 | 30 | 0 | 0 | 0 | 29.1 | 26 | 12 | 11 | 4 | 6 | 30 | 0 | 1.09 | .232 |