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| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Jake Peavy | CWS | 2.74 | 6 | 3 | 0 | 0 | 14 | 14 | 3 | 1 | 98.2 | 70 | 32 | 30 | 8 | 23 | 83 | 12 | 0.94 | .198 |
| Justin Verlander | DET | 2.57 | 7 | 4 | 0 | 0 | 15 | 15 | 3 | 1 | 108.2 | 81 | 37 | 31 | 6 | 27 | 106 | 12 | 0.99 | .204 | |
| C.J. Wilson | LAA | 2.44 | 8 | 4 | 0 | 0 | 15 | 15 | 0 | 0 | 92.1 | 67 | 31 | 25 | 4 | 39 | 79 | 12 | 1.15 | .203 | |
| 4 | Matt Harrison | TEX | 3.41 | 9 | 3 | 0 | 0 | 14 | 14 | 1 | 1 | 92.1 | 93 | 36 | 35 | 7 | 22 | 55 | 10 | 1.25 | .261 |
| Colby Lewis | TEX | 3.00 | 6 | 5 | 0 | 0 | 14 | 14 | 2 | 0 | 96 | 84 | 39 | 32 | 15 | 12 | 84 | 10 | 1.00 | .231 | |
| Derek Lowe | CLE | 4.30 | 7 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 83.2 | 105 | 42 | 40 | 5 | 27 | 30 | 10 | 1.58 | .313 | |
| Justin Masterson | CLE | 3.98 | 4 | 6 | 0 | 0 | 15 | 15 | 1 | 0 | 97.1 | 87 | 47 | 43 | 7 | 40 | 77 | 10 | 1.30 | .242 | |
| 8 | Jon Lester | BOS | 4.48 | 4 | 5 | 0 | 0 | 15 | 15 | 2 | 0 | 94.1 | 102 | 52 | 47 | 8 | 27 | 75 | 9 | 1.37 | .278 |
| Brandon McCarthy | OAK | 2.54 | 6 | 3 | 0 | 0 | 12 | 12 | 0 | 0 | 78 | 75 | 25 | 22 | 5 | 19 | 52 | 9 | 1.21 | .252 | |
| David Price | TB | 3.08 | 9 | 4 | 0 | 0 | 14 | 14 | 1 | 1 | 90.2 | 84 | 33 | 31 | 7 | 31 | 82 | 9 | 1.27 | .248 | |
| CC Sabathia | NYY | 3.55 | 9 | 3 | 0 | 0 | 14 | 14 | 1 | 0 | 101.1 | 98 | 45 | 40 | 10 | 27 | 102 | 9 | 1.23 | .250 | |
| Chris Sale | CWS | 2.24 | 8 | 2 | 0 | 1 | 14 | 13 | 1 | 0 | 88.1 | 62 | 23 | 22 | 4 | 23 | 89 | 9 | 0.96 | .194 | |
| Jered Weaver | LAA | 2.40 | 7 | 1 | 0 | 0 | 12 | 12 | 2 | 1 | 75 | 51 | 23 | 20 | 5 | 17 | 60 | 9 | 0.91 | .189 | |
| 14 | Henderson Alvarez | TOR | 4.30 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 90 | 103 | 47 | 43 | 16 | 20 | 27 | 8 | 1.37 | .289 |
| Josh Beckett | BOS | 4.14 | 4 | 7 | 0 | 0 | 12 | 12 | 0 | 0 | 78.1 | 73 | 36 | 36 | 9 | 17 | 56 | 8 | 1.15 | .247 | |
| Yu Darvish | TEX | 3.45 | 9 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 88.2 | 78 | 38 | 34 | 7 | 49 | 96 | 8 | 1.43 | .234 | |
| Felix Doubront | BOS | 4.31 | 8 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 79.1 | 79 | 42 | 38 | 11 | 28 | 85 | 8 | 1.35 | .254 | |
| Jason Hammel | BAL | 2.61 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 89.2 | 71 | 29 | 26 | 7 | 29 | 87 | 8 | 1.12 | .215 | |
| Jeremy Hellickson | TB | 3.45 | 4 | 3 | 0 | 0 | 13 | 13 | 0 | 0 | 78.1 | 75 | 36 | 30 | 14 | 30 | 52 | 8 | 1.34 | .251 | |
| Felix Hernandez | SEA | 3.52 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 94.2 | 92 | 39 | 37 | 9 | 30 | 91 | 8 | 1.29 | .256 | |
| Ubaldo Jimenez | CLE | 4.59 | 7 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 82.1 | 79 | 45 | 42 | 11 | 49 | 58 | 8 | 1.55 | .249 | |
| Hiroki Kuroda | NYY | 3.57 | 6 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 88.1 | 86 | 38 | 35 | 12 | 28 | 62 | 8 | 1.29 | .257 | |
| Brandon Morrow | TOR | 3.01 | 7 | 4 | 0 | 0 | 13 | 13 | 3 | 3 | 77.2 | 54 | 28 | 26 | 7 | 24 | 67 | 8 | 1.00 | .194 | |
| Jarrod Parker | OAK | 2.70 | 3 | 3 | 0 | 0 | 11 | 11 | 0 | 0 | 66.2 | 50 | 20 | 20 | 2 | 32 | 49 | 8 | 1.23 | .214 | |
| Max Scherzer | DET | 5.17 | 6 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 78.1 | 90 | 49 | 45 | 13 | 29 | 100 | 8 | 1.52 | .288 | |
| James Shields | TB | 3.72 | 7 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 92 | 94 | 50 | 38 | 10 | 30 | 86 | 8 | 1.35 | .258 | |
| Jason Vargas | SEA | 4.66 | 7 | 7 | 0 | 0 | 16 | 16 | 0 | 0 | 102.1 | 98 | 53 | 53 | 20 | 27 | 64 | 8 | 1.22 | .254 | |
| Jerome Williams | LAA | 4.46 | 6 | 5 | 0 | 0 | 13 | 12 | 1 | 1 | 82.2 | 88 | 44 | 41 | 7 | 26 | 56 | 8 | 1.38 | .273 | |
| 29 | Bruce Chen | KC | 4.81 | 6 | 6 | 0 | 0 | 15 | 15 | 0 | 0 | 82.1 | 88 | 45 | 44 | 9 | 18 | 59 | 7 | 1.29 | .272 |
| Wei-Yin Chen | BAL | 3.36 | 7 | 2 | 0 | 0 | 13 | 13 | 0 | 0 | 80.1 | 79 | 34 | 30 | 8 | 25 | 57 | 7 | 1.29 | .256 | |
| Bartolo Colon | OAK | 4.22 | 6 | 7 | 0 | 0 | 15 | 15 | 0 | 0 | 89.2 | 101 | 43 | 42 | 12 | 16 | 55 | 7 | 1.30 | .283 | |
| Dan Haren | LAA | 4.24 | 5 | 7 | 0 | 0 | 15 | 15 | 1 | 1 | 93.1 | 106 | 46 | 44 | 13 | 22 | 82 | 7 | 1.37 | .289 | |
| Tommy Milone | OAK | 4.13 | 7 | 5 | 0 | 0 | 14 | 14 | 1 | 0 | 89.1 | 84 | 43 | 41 | 13 | 24 | 52 | 7 | 1.21 | .247 | |
| Ivan Nova | NYY | 4.32 | 9 | 2 | 0 | 0 | 13 | 13 | 0 | 0 | 85.1 | 95 | 41 | 41 | 14 | 23 | 73 | 7 | 1.38 | .287 | |
| Rick Porcello | DET | 4.95 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 80 | 106 | 50 | 44 | 8 | 20 | 46 | 7 | 1.58 | .319 | |
| Ricky Romero | TOR | 4.34 | 8 | 1 | 0 | 0 | 15 | 15 | 0 | 0 | 95.1 | 82 | 50 | 46 | 13 | 46 | 69 | 7 | 1.34 | .232 | |
| 37 | Scott Diamond | MIN | 2.57 | 5 | 3 | 0 | 0 | 9 | 9 | 0 | 0 | 56 | 62 | 22 | 16 | 7 | 8 | 30 | 6 | 1.25 | .279 |
| Kyle Drabek | TOR | 4.67 | 4 | 7 | 0 | 0 | 13 | 13 | 0 | 0 | 71.1 | 67 | 41 | 37 | 10 | 47 | 47 | 6 | 1.60 | .250 | |
| Doug Fister | DET | 2.72 | 1 | 4 | 0 | 0 | 8 | 8 | 0 | 0 | 46.1 | 48 | 17 | 14 | 4 | 10 | 37 | 6 | 1.25 | .264 | |
| Gavin Floyd | CWS | 5.20 | 5 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 83 | 84 | 49 | 48 | 15 | 24 | 76 | 6 | 1.30 | .262 | |
| Luke Hochevar | KC | 5.65 | 4 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 78 | 87 | 50 | 49 | 6 | 27 | 60 | 6 | 1.46 | .291 | |
| Derek Holland | TEX | 5.10 | 5 | 4 | 0 | 0 | 12 | 11 | 0 | 0 | 67 | 65 | 42 | 38 | 11 | 24 | 59 | 6 | 1.33 | .251 | |
| Phil Hughes | NYY | 4.94 | 7 | 6 | 0 | 0 | 14 | 14 | 1 | 0 | 78.1 | 85 | 47 | 43 | 19 | 20 | 77 | 6 | 1.34 | .269 | |
| Brian Matusz | BAL | 5.00 | 5 | 8 | 0 | 0 | 14 | 14 | 0 | 0 | 75.2 | 87 | 49 | 42 | 10 | 35 | 59 | 6 | 1.61 | .282 | |
| Kevin Millwood | SEA | 4.02 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 80.2 | 79 | 43 | 36 | 3 | 33 | 59 | 6 | 1.39 | .257 | |
| Matt Moore | TB | 4.13 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 80.2 | 71 | 44 | 37 | 11 | 40 | 85 | 6 | 1.38 | .233 | |
| Hector Noesi | SEA | 5.69 | 2 | 8 | 0 | 0 | 14 | 14 | 0 | 0 | 80.2 | 73 | 52 | 51 | 15 | 30 | 50 | 6 | 1.28 | .246 | |
| Ervin Santana | LAA | 5.16 | 4 | 7 | 0 | 0 | 14 | 14 | 1 | 1 | 89 | 83 | 52 | 51 | 18 | 36 | 61 | 6 | 1.34 | .243 | |
| 49 | Jake Arrieta | BAL | 5.83 | 3 | 9 | 0 | 0 | 15 | 15 | 0 | 0 | 88 | 94 | 60 | 57 | 12 | 25 | 79 | 5 | 1.35 | .271 |
| Clay Buchholz | BOS | 5.53 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 86.1 | 99 | 55 | 53 | 15 | 34 | 58 | 5 | 1.54 | .295 | |
| Philip Humber | CWS | 6.01 | 3 | 4 | 0 | 0 | 12 | 12 | 1 | 1 | 67.1 | 69 | 46 | 45 | 12 | 31 | 63 | 5 | 1.49 | .261 | |
| Tommy Hunter | BAL | 5.70 | 3 | 4 | 0 | 0 | 13 | 13 | 0 | 0 | 77.1 | 91 | 53 | 49 | 18 | 15 | 41 | 5 | 1.37 | .296 | |
| Andy Pettitte | NYY | 3.29 | 3 | 3 | 0 | 0 | 8 | 8 | 0 | 0 | 54.2 | 46 | 21 | 20 | 7 | 14 | 52 | 5 | 1.10 | .228 | |
| Tyson Ross | OAK | 6.11 | 2 | 6 | 0 | 0 | 10 | 10 | 0 | 0 | 53 | 67 | 36 | 36 | 7 | 25 | 29 | 5 | 1.74 | .318 | |
| Drew Smyly | DET | 3.96 | 2 | 2 | 0 | 0 | 12 | 12 | 0 | 0 | 63.2 | 63 | 30 | 28 | 10 | 18 | 58 | 5 | 1.27 | .259 | |
| Josh Tomlin | CLE | 5.12 | 3 | 4 | 0 | 0 | 11 | 10 | 0 | 0 | 63.1 | 74 | 37 | 36 | 8 | 15 | 38 | 5 | 1.41 | .291 | |
| 57 | Blake Beavan | SEA | 5.92 | 3 | 6 | 0 | 0 | 12 | 12 | 0 | 0 | 62.1 | 77 | 41 | 41 | 12 | 11 | 30 | 4 | 1.41 | .297 |
| John Danks | CWS | 5.70 | 3 | 4 | 0 | 0 | 9 | 9 | 0 | 0 | 53.2 | 57 | 35 | 34 | 7 | 23 | 30 | 4 | 1.49 | .273 | |
| Neftali Feliz | TEX | 3.16 | 3 | 1 | 0 | 0 | 8 | 7 | 1 | 0 | 42.2 | 28 | 15 | 15 | 5 | 23 | 37 | 4 | 1.20 | .187 | |
| Jeanmar Gomez | CLE | 4.95 | 4 | 6 | 0 | 0 | 13 | 12 | 0 | 0 | 67.1 | 69 | 43 | 37 | 8 | 25 | 32 | 4 | 1.40 | .264 | |
| Drew Hutchison | TOR | 4.60 | 5 | 3 | 0 | 0 | 11 | 11 | 0 | 0 | 58.2 | 59 | 31 | 30 | 8 | 20 | 49 | 4 | 1.35 | .257 | |
| Francisco Liriano | MIN | 5.74 | 1 | 7 | 0 | 0 | 16 | 11 | 0 | 0 | 64.1 | 60 | 43 | 41 | 7 | 38 | 65 | 4 | 1.52 | .252 | |
| Felipe Paulino | KC | 1.67 | 3 | 1 | 0 | 0 | 7 | 7 | 0 | 0 | 37.2 | 31 | 8 | 7 | 3 | 15 | 39 | 4 | 1.22 | .223 | |
| Carl Pavano | MIN | 6.00 | 2 | 5 | 0 | 0 | 11 | 11 | 0 | 0 | 63 | 80 | 46 | 42 | 9 | 8 | 33 | 4 | 1.40 | .313 | |
| P.J. Walters | MIN | 5.40 | 2 | 2 | 0 | 0 | 7 | 7 | 1 | 0 | 36.2 | 42 | 22 | 22 | 7 | 14 | 23 | 4 | 1.53 | .300 | |
| 66 | Daniel Bard | BOS | 5.24 | 5 | 6 | 0 | 0 | 11 | 10 | 0 | 0 | 55 | 52 | 33 | 32 | 6 | 37 | 34 | 3 | 1.62 | .259 |
| Jose Quintana | CWS | 1.53 | 2 | 1 | 0 | 0 | 7 | 5 | 0 | 0 | 35.1 | 30 | 6 | 6 | 2 | 6 | 20 | 3 | 1.02 | .238 | |
| 68 | Travis Blackley | OAK | 3.89 | 1 | 2 | 0 | 0 | 12 | 5 | 0 | 0 | 39.1 | 35 | 20 | 17 | 1 | 10 | 25 | 2 | 1.14 | .236 |
| Alex Cobb | TB | 3.82 | 3 | 3 | 0 | 0 | 6 | 6 | 0 | 0 | 37.2 | 32 | 18 | 16 | 2 | 12 | 32 | 2 | 1.17 | .227 | |
| Danny Duffy | KC | 3.90 | 2 | 2 | 0 | 0 | 6 | 6 | 0 | 0 | 27.2 | 26 | 13 | 12 | 2 | 18 | 28 | 2 | 1.59 | .252 | |
| Vin Mazzaro | KC | 5.24 | 3 | 2 | 0 | 0 | 6 | 5 | 0 | 0 | 22.1 | 25 | 14 | 13 | 0 | 11 | 15 | 2 | 1.61 | .294 | |
| Zach McAllister | CLE | 3.96 | 1 | 1 | 0 | 0 | 4 | 4 | 0 | 0 | 25 | 25 | 14 | 11 | 1 | 6 | 22 | 2 | 1.24 | .255 | |
| Luis Mendoza | KC | 4.69 | 2 | 3 | 0 | 0 | 12 | 7 | 0 | 0 | 55.2 | 61 | 33 | 29 | 4 | 28 | 28 | 2 | 1.60 | .284 | |
| Garrett Richards | LAA | 0.86 | 2 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 21 | 13 | 3 | 2 | 1 | 11 | 17 | 2 | 1.14 | .183 | |
| 75 | Chris Archer | TB | 1.50 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 6 | 3 | 3 | 1 | 0 | 1 | 7 | 1 | 0.67 | .143 |
| Nick Blackburn | MIN | 7.45 | 4 | 4 | 0 | 0 | 11 | 11 | 0 | 0 | 54.1 | 73 | 45 | 45 | 11 | 21 | 26 | 1 | 1.73 | .323 | |
| Dana Eveland | BAL | 3.24 | 0 | 0 | 0 | 0 | 10 | 1 | 0 | 0 | 25 | 22 | 10 | 9 | 1 | 11 | 13 | 1 | 1.32 | .239 | |
| Scott Feldman | TEX | 6.00 | 1 | 6 | 0 | 0 | 13 | 8 | 0 | 0 | 42 | 48 | 35 | 28 | 5 | 14 | 32 | 1 | 1.48 | .276 | |
| Graham Godfrey | OAK | 6.43 | 0 | 4 | 0 | 0 | 5 | 4 | 0 | 0 | 21 | 26 | 18 | 15 | 4 | 10 | 10 | 1 | 1.71 | .317 | |
| Justin Grimm | TEX | 4.50 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 6 | 6 | 3 | 3 | 1 | 0 | 7 | 1 | 1.00 | .261 | |
| Liam Hendriks | MIN | 7.39 | 0 | 4 | 0 | 0 | 6 | 6 | 0 | 0 | 28 | 46 | 29 | 23 | 9 | 5 | 17 | 1 | 1.82 | .371 | |
| Daisuke Matsuzaka | BOS | 6.06 | 0 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 16.1 | 13 | 11 | 11 | 2 | 5 | 15 | 1 | 1.10 | .213 | |
| Jeff Niemann | TB | 3.38 | 2 | 3 | 0 | 0 | 7 | 7 | 0 | 0 | 34.2 | 29 | 17 | 13 | 2 | 12 | 30 | 1 | 1.18 | .221 | |
| Roy Oswalt | TEX | 1.35 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 6.2 | 9 | 1 | 1 | 0 | 1 | 6 | 1 | 1.50 | .321 | |
| Jonathan Sanchez | KC | 5.70 | 1 | 3 | 0 | 0 | 8 | 8 | 0 | 0 | 36.1 | 38 | 24 | 23 | 3 | 28 | 25 | 1 | 1.82 | .273 | |
| Will Smith | KC | 9.00 | 1 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 14 | 18 | 14 | 14 | 6 | 5 | 9 | 1 | 1.64 | .300 |