| Career Leaders | MLB Leaders | AL Leaders | NL Leaders | Team Leaders |
| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Jason Vargas | SEA | 4.66 | 7 | 7 | 0 | 0 | 16 | 16 | 0 | 0 | 102.1 | 98 | 53 | 53 | 20 | 27 | 64 | 8 | 1.22 | .254 |
| 2 | Phil Hughes | NYY | 4.94 | 7 | 6 | 0 | 0 | 14 | 14 | 1 | 0 | 78.1 | 85 | 47 | 43 | 19 | 20 | 77 | 6 | 1.34 | .269 |
| 3 | Tommy Hunter | BAL | 5.70 | 3 | 4 | 0 | 0 | 13 | 13 | 0 | 0 | 77.1 | 91 | 53 | 49 | 18 | 15 | 41 | 5 | 1.37 | .296 |
| Ervin Santana | LAA | 5.16 | 4 | 7 | 0 | 0 | 14 | 14 | 1 | 1 | 89 | 83 | 52 | 51 | 18 | 36 | 61 | 6 | 1.34 | .243 | |
| 5 | Henderson Alvarez | TOR | 4.30 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 90 | 103 | 47 | 43 | 16 | 20 | 27 | 8 | 1.37 | .289 |
| 6 | Clay Buchholz | BOS | 5.53 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 86.1 | 99 | 55 | 53 | 15 | 34 | 58 | 5 | 1.54 | .295 |
| Gavin Floyd | CWS | 5.20 | 5 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 83 | 84 | 49 | 48 | 15 | 24 | 76 | 6 | 1.30 | .262 | |
| Colby Lewis | TEX | 3.00 | 6 | 5 | 0 | 0 | 14 | 14 | 2 | 0 | 96 | 84 | 39 | 32 | 15 | 12 | 84 | 10 | 1.00 | .231 | |
| Hector Noesi | SEA | 5.69 | 2 | 8 | 0 | 0 | 14 | 14 | 0 | 0 | 80.2 | 73 | 52 | 51 | 15 | 30 | 50 | 6 | 1.28 | .246 | |
| 10 | Jeremy Hellickson | TB | 3.45 | 4 | 3 | 0 | 0 | 13 | 13 | 0 | 0 | 78.1 | 75 | 36 | 30 | 14 | 30 | 52 | 8 | 1.34 | .251 |
| Ivan Nova | NYY | 4.32 | 9 | 2 | 0 | 0 | 13 | 13 | 0 | 0 | 85.1 | 95 | 41 | 41 | 14 | 23 | 73 | 7 | 1.38 | .287 | |
| 12 | Dan Haren | LAA | 4.24 | 5 | 7 | 0 | 0 | 15 | 15 | 1 | 1 | 93.1 | 106 | 46 | 44 | 13 | 22 | 82 | 7 | 1.37 | .289 |
| Tommy Milone | OAK | 4.13 | 7 | 5 | 0 | 0 | 14 | 14 | 1 | 0 | 89.1 | 84 | 43 | 41 | 13 | 24 | 52 | 7 | 1.21 | .247 | |
| Ricky Romero | TOR | 4.34 | 8 | 1 | 0 | 0 | 15 | 15 | 0 | 0 | 95.1 | 82 | 50 | 46 | 13 | 46 | 69 | 7 | 1.34 | .232 | |
| Max Scherzer | DET | 5.17 | 6 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 78.1 | 90 | 49 | 45 | 13 | 29 | 100 | 8 | 1.52 | .288 | |
| 16 | Jake Arrieta | BAL | 5.83 | 3 | 9 | 0 | 0 | 15 | 15 | 0 | 0 | 88 | 94 | 60 | 57 | 12 | 25 | 79 | 5 | 1.35 | .271 |
| Blake Beavan | SEA | 5.92 | 3 | 6 | 0 | 0 | 12 | 12 | 0 | 0 | 62.1 | 77 | 41 | 41 | 12 | 11 | 30 | 4 | 1.41 | .297 | |
| Bartolo Colon | OAK | 4.22 | 6 | 7 | 0 | 0 | 15 | 15 | 0 | 0 | 89.2 | 101 | 43 | 42 | 12 | 16 | 55 | 7 | 1.30 | .283 | |
| Philip Humber | CWS | 6.01 | 3 | 4 | 0 | 0 | 12 | 12 | 1 | 1 | 67.1 | 69 | 46 | 45 | 12 | 31 | 63 | 5 | 1.49 | .261 | |
| Hiroki Kuroda | NYY | 3.57 | 6 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 88.1 | 86 | 38 | 35 | 12 | 28 | 62 | 8 | 1.29 | .257 | |
| 21 | Nick Blackburn | MIN | 7.45 | 4 | 4 | 0 | 0 | 11 | 11 | 0 | 0 | 54.1 | 73 | 45 | 45 | 11 | 21 | 26 | 1 | 1.73 | .323 |
| Felix Doubront | BOS | 4.31 | 8 | 3 | 0 | 0 | 14 | 14 | 0 | 0 | 79.1 | 79 | 42 | 38 | 11 | 28 | 85 | 8 | 1.35 | .254 | |
| Derek Holland | TEX | 5.10 | 5 | 4 | 0 | 0 | 12 | 11 | 0 | 0 | 67 | 65 | 42 | 38 | 11 | 24 | 59 | 6 | 1.33 | .251 | |
| Ubaldo Jimenez | CLE | 4.59 | 7 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 82.1 | 79 | 45 | 42 | 11 | 49 | 58 | 8 | 1.55 | .249 | |
| Matt Moore | TB | 4.13 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 80.2 | 71 | 44 | 37 | 11 | 40 | 85 | 6 | 1.38 | .233 | |
| 26 | Kyle Drabek | TOR | 4.67 | 4 | 7 | 0 | 0 | 13 | 13 | 0 | 0 | 71.1 | 67 | 41 | 37 | 10 | 47 | 47 | 6 | 1.60 | .250 |
| Brian Matusz | BAL | 5.00 | 5 | 8 | 0 | 0 | 14 | 14 | 0 | 0 | 75.2 | 87 | 49 | 42 | 10 | 35 | 59 | 6 | 1.61 | .282 | |
| CC Sabathia | NYY | 3.55 | 9 | 3 | 0 | 0 | 14 | 14 | 1 | 0 | 101.1 | 98 | 45 | 40 | 10 | 27 | 102 | 9 | 1.23 | .250 | |
| James Shields | TB | 3.72 | 7 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 92 | 94 | 50 | 38 | 10 | 30 | 86 | 8 | 1.35 | .258 | |
| Drew Smyly | DET | 3.96 | 2 | 2 | 0 | 0 | 12 | 12 | 0 | 0 | 63.2 | 63 | 30 | 28 | 10 | 18 | 58 | 5 | 1.27 | .259 | |
| Zach Stewart | CWS | 6.00 | 1 | 2 | 0 | 0 | 18 | 1 | 0 | 0 | 30 | 41 | 26 | 20 | 10 | 4 | 16 | 0 | 1.50 | .320 | |
| 32 | Josh Beckett | BOS | 4.14 | 4 | 7 | 0 | 0 | 12 | 12 | 0 | 0 | 78.1 | 73 | 36 | 36 | 9 | 17 | 56 | 8 | 1.15 | .247 |
| Bruce Chen | KC | 4.81 | 6 | 6 | 0 | 0 | 15 | 15 | 0 | 0 | 82.1 | 88 | 45 | 44 | 9 | 18 | 59 | 7 | 1.29 | .272 | |
| Liam Hendriks | MIN | 7.39 | 0 | 4 | 0 | 0 | 6 | 6 | 0 | 0 | 28 | 46 | 29 | 23 | 9 | 5 | 17 | 1 | 1.82 | .371 | |
| Felix Hernandez | SEA | 3.52 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 94.2 | 92 | 39 | 37 | 9 | 30 | 91 | 8 | 1.29 | .256 | |
| Carl Pavano | MIN | 6.00 | 2 | 5 | 0 | 0 | 11 | 11 | 0 | 0 | 63 | 80 | 46 | 42 | 9 | 8 | 33 | 4 | 1.40 | .313 | |
| 37 | Wei-Yin Chen | BAL | 3.36 | 7 | 2 | 0 | 0 | 13 | 13 | 0 | 0 | 80.1 | 79 | 34 | 30 | 8 | 25 | 57 | 7 | 1.29 | .256 |
| Jeanmar Gomez | CLE | 4.95 | 4 | 6 | 0 | 0 | 13 | 12 | 0 | 0 | 67.1 | 69 | 43 | 37 | 8 | 25 | 32 | 4 | 1.40 | .264 | |
| Drew Hutchison | TOR | 4.60 | 5 | 3 | 0 | 0 | 11 | 11 | 0 | 0 | 58.2 | 59 | 31 | 30 | 8 | 20 | 49 | 4 | 1.35 | .257 | |
| Jon Lester | BOS | 4.48 | 4 | 5 | 0 | 0 | 15 | 15 | 2 | 0 | 94.1 | 102 | 52 | 47 | 8 | 27 | 75 | 9 | 1.37 | .278 | |
| Jake Peavy | CWS | 2.74 | 6 | 3 | 0 | 0 | 14 | 14 | 3 | 1 | 98.2 | 70 | 32 | 30 | 8 | 23 | 83 | 12 | 0.94 | .198 | |
| Rick Porcello | DET | 4.95 | 4 | 5 | 0 | 0 | 14 | 14 | 0 | 0 | 80 | 106 | 50 | 44 | 8 | 20 | 46 | 7 | 1.58 | .319 | |
| Josh Tomlin | CLE | 5.12 | 3 | 4 | 0 | 0 | 11 | 10 | 0 | 0 | 63.1 | 74 | 37 | 36 | 8 | 15 | 38 | 5 | 1.41 | .291 | |
| 44 | John Danks | CWS | 5.70 | 3 | 4 | 0 | 0 | 9 | 9 | 0 | 0 | 53.2 | 57 | 35 | 34 | 7 | 23 | 30 | 4 | 1.49 | .273 |
| Yu Darvish | TEX | 3.45 | 9 | 4 | 0 | 0 | 14 | 14 | 0 | 0 | 88.2 | 78 | 38 | 34 | 7 | 49 | 96 | 8 | 1.43 | .234 | |
| Steve Delabar | SEA | 4.78 | 1 | 1 | 0 | 1 | 26 | 0 | 0 | 0 | 26.1 | 18 | 14 | 14 | 7 | 8 | 34 | 0 | 0.99 | .188 | |
| Scott Diamond | MIN | 2.57 | 5 | 3 | 0 | 0 | 9 | 9 | 0 | 0 | 56 | 62 | 22 | 16 | 7 | 8 | 30 | 6 | 1.25 | .279 | |
| Jason Hammel | BAL | 2.61 | 8 | 2 | 0 | 0 | 14 | 14 | 1 | 1 | 89.2 | 71 | 29 | 26 | 7 | 29 | 87 | 8 | 1.12 | .215 | |
| Matt Harrison | TEX | 3.41 | 9 | 3 | 0 | 0 | 14 | 14 | 1 | 1 | 92.1 | 93 | 36 | 35 | 7 | 22 | 55 | 10 | 1.25 | .261 | |
| Francisco Liriano | MIN | 5.74 | 1 | 7 | 0 | 0 | 16 | 11 | 0 | 0 | 64.1 | 60 | 43 | 41 | 7 | 38 | 65 | 4 | 1.52 | .252 | |
| Justin Masterson | CLE | 3.98 | 4 | 6 | 0 | 0 | 15 | 15 | 1 | 0 | 97.1 | 87 | 47 | 43 | 7 | 40 | 77 | 10 | 1.30 | .242 | |
| Brandon Morrow | TOR | 3.01 | 7 | 4 | 0 | 0 | 13 | 13 | 3 | 3 | 77.2 | 54 | 28 | 26 | 7 | 24 | 67 | 8 | 1.00 | .194 | |
| Andy Pettitte | NYY | 3.29 | 3 | 3 | 0 | 0 | 8 | 8 | 0 | 0 | 54.2 | 46 | 21 | 20 | 7 | 14 | 52 | 5 | 1.10 | .228 | |
| David Price | TB | 3.08 | 9 | 4 | 0 | 0 | 14 | 14 | 1 | 1 | 90.2 | 84 | 33 | 31 | 7 | 31 | 82 | 9 | 1.27 | .248 | |
| Tyson Ross | OAK | 6.11 | 2 | 6 | 0 | 0 | 10 | 10 | 0 | 0 | 53 | 67 | 36 | 36 | 7 | 25 | 29 | 5 | 1.74 | .318 | |
| Anthony Swarzak | MIN | 5.04 | 1 | 4 | 0 | 0 | 20 | 4 | 0 | 0 | 50 | 56 | 28 | 28 | 7 | 12 | 30 | 0 | 1.36 | .290 | |
| P.J. Walters | MIN | 5.40 | 2 | 2 | 0 | 0 | 7 | 7 | 1 | 0 | 36.2 | 42 | 22 | 22 | 7 | 14 | 23 | 4 | 1.53 | .300 | |
| Jerome Williams | LAA | 4.46 | 6 | 5 | 0 | 0 | 13 | 12 | 1 | 1 | 82.2 | 88 | 44 | 41 | 7 | 26 | 56 | 8 | 1.38 | .273 | |
| 59 | Daniel Bard | BOS | 5.24 | 5 | 6 | 0 | 0 | 11 | 10 | 0 | 0 | 55 | 52 | 33 | 32 | 6 | 37 | 34 | 3 | 1.62 | .259 |
| Luke Hochevar | KC | 5.65 | 4 | 7 | 0 | 0 | 14 | 14 | 0 | 0 | 78 | 87 | 50 | 49 | 6 | 27 | 60 | 6 | 1.46 | .291 | |
| Hector Santiago | CWS | 4.15 | 1 | 1 | 4 | 6 | 23 | 0 | 0 | 0 | 26 | 25 | 12 | 12 | 6 | 11 | 30 | 0 | 1.38 | .245 | |
| Will Smith | KC | 9.00 | 1 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 14 | 18 | 14 | 14 | 6 | 5 | 9 | 1 | 1.64 | .300 | |
| Justin Verlander | DET | 2.57 | 7 | 4 | 0 | 0 | 15 | 15 | 3 | 1 | 108.2 | 81 | 37 | 31 | 6 | 27 | 106 | 12 | 0.99 | .204 | |
| 64 | Collin Balester | DET | 6.50 | 2 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | 18 | 14 | 14 | 13 | 5 | 11 | 12 | 0 | 1.39 | .209 |
| Joel Carreno | TOR | 6.60 | 0 | 2 | 0 | 0 | 6 | 2 | 0 | 0 | 15 | 16 | 11 | 11 | 5 | 11 | 9 | 0 | 1.80 | .276 | |
| Louis Coleman | KC | 4.91 | 0 | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 22 | 19 | 14 | 12 | 5 | 13 | 23 | 0 | 1.45 | .229 | |
| Francisco Cordero | TOR | 5.08 | 2 | 4 | 2 | 5 | 33 | 0 | 0 | 0 | 28.1 | 36 | 18 | 16 | 5 | 13 | 21 | 0 | 1.73 | .319 | |
| Scott Feldman | TEX | 6.00 | 1 | 6 | 0 | 0 | 13 | 8 | 0 | 0 | 42 | 48 | 35 | 28 | 5 | 14 | 32 | 1 | 1.48 | .276 | |
| Neftali Feliz | TEX | 3.16 | 3 | 1 | 0 | 0 | 8 | 7 | 1 | 0 | 42.2 | 28 | 15 | 15 | 5 | 23 | 37 | 4 | 1.20 | .187 | |
| Hisashi Iwakuma | SEA | 5.06 | 1 | 0 | 2 | 2 | 13 | 0 | 0 | 0 | 26.2 | 27 | 15 | 15 | 5 | 13 | 20 | 0 | 1.50 | .270 | |
| Derek Lowe | CLE | 4.30 | 7 | 5 | 0 | 0 | 14 | 14 | 1 | 1 | 83.2 | 105 | 42 | 40 | 5 | 27 | 30 | 10 | 1.58 | .313 | |
| Brandon McCarthy | OAK | 2.54 | 6 | 3 | 0 | 0 | 12 | 12 | 0 | 0 | 78 | 75 | 25 | 22 | 5 | 19 | 52 | 9 | 1.21 | .252 | |
| Mark Melancon | BOS | 15.43 | 0 | 2 | 0 | 1 | 9 | 0 | 0 | 0 | 7 | 13 | 12 | 12 | 5 | 4 | 4 | 0 | 2.43 | .406 | |
| Will Ohman | CWS | 5.70 | 0 | 2 | 0 | 1 | 29 | 0 | 0 | 0 | 23.2 | 18 | 15 | 15 | 5 | 4 | 11 | 0 | 0.93 | .205 | |
| Joel Peralta | TB | 4.20 | 0 | 3 | 2 | 5 | 36 | 0 | 0 | 0 | 30 | 23 | 14 | 14 | 5 | 8 | 36 | 0 | 1.03 | .207 | |
| David Phelps | NYY | 2.94 | 1 | 2 | 0 | 0 | 13 | 2 | 0 | 0 | 33.2 | 31 | 12 | 11 | 5 | 13 | 29 | 0 | 1.31 | .246 | |
| Tony Sipp | CLE | 6.95 | 0 | 2 | 1 | 1 | 27 | 0 | 0 | 0 | 22 | 24 | 18 | 17 | 5 | 10 | 25 | 0 | 1.55 | .273 | |
| Carlos Villanueva | TOR | 3.24 | 2 | 0 | 0 | 0 | 22 | 0 | 0 | 0 | 33.1 | 26 | 13 | 12 | 5 | 21 | 36 | 0 | 1.41 | .211 | |
| Jered Weaver | LAA | 2.40 | 7 | 1 | 0 | 0 | 12 | 12 | 2 | 1 | 75 | 51 | 23 | 20 | 5 | 17 | 60 | 9 | 0.91 | .189 | |
| 80 | Burke Badenhop | TB | 2.87 | 1 | 1 | 0 | 0 | 32 | 0 | 0 | 0 | 31.1 | 32 | 11 | 10 | 4 | 5 | 26 | 0 | 1.18 | .258 |
| Jared Burton | MIN | 3.10 | 1 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 29 | 22 | 11 | 10 | 4 | 3 | 29 | 0 | 0.86 | .206 | |
| Matt Capps | MIN | 3.55 | 1 | 4 | 14 | 15 | 26 | 0 | 0 | 0 | 25.1 | 23 | 10 | 10 | 4 | 3 | 15 | 0 | 1.03 | .235 | |
| Cole De Vries | MIN | 4.20 | 1 | 1 | 0 | 0 | 3 | 3 | 0 | 0 | 15 | 14 | 11 | 7 | 4 | 6 | 9 | 0 | 1.33 | .241 | |
| Doug Fister | DET | 2.72 | 1 | 4 | 0 | 0 | 8 | 8 | 0 | 0 | 46.1 | 48 | 17 | 14 | 4 | 10 | 37 | 6 | 1.25 | .264 | |
| Brian Fuentes | OAK | 5.79 | 2 | 2 | 5 | 8 | 24 | 0 | 0 | 0 | 23.1 | 26 | 15 | 15 | 4 | 6 | 17 | 0 | 1.37 | .277 | |
| Freddy Garcia | NYY | 7.16 | 1 | 2 | 0 | 0 | 12 | 4 | 0 | 0 | 27.2 | 37 | 24 | 22 | 4 | 8 | 20 | 0 | 1.63 | .322 | |
| Graham Godfrey | OAK | 6.43 | 0 | 4 | 0 | 0 | 5 | 4 | 0 | 0 | 21 | 26 | 18 | 15 | 4 | 10 | 10 | 1 | 1.71 | .317 | |
| Jeff Gray | MIN | 4.40 | 3 | 0 | 0 | 0 | 29 | 0 | 0 | 0 | 30.2 | 30 | 16 | 15 | 4 | 15 | 17 | 0 | 1.47 | .248 | |
| Kelvin Herrera | KC | 3.03 | 0 | 1 | 0 | 0 | 33 | 0 | 0 | 0 | 38.2 | 32 | 14 | 13 | 4 | 7 | 37 | 0 | 1.01 | .222 | |
| J.P. Howell | TB | 5.57 | 1 | 0 | 0 | 0 | 25 | 0 | 0 | 0 | 21 | 19 | 13 | 13 | 4 | 9 | 19 | 0 | 1.33 | .247 | |
| Casey Janssen | TOR | 2.70 | 1 | 1 | 7 | 8 | 26 | 0 | 0 | 0 | 26.2 | 21 | 8 | 8 | 4 | 5 | 23 | 0 | 0.98 | .216 | |
| Jeff Manship | MIN | 9.31 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 9.2 | 13 | 10 | 10 | 4 | 3 | 5 | 0 | 1.66 | .325 | |
| Luis Mendoza | KC | 4.69 | 2 | 3 | 0 | 0 | 12 | 7 | 0 | 0 | 55.2 | 61 | 33 | 29 | 4 | 28 | 28 | 2 | 1.60 | .284 | |
| Chris Sale | CWS | 2.24 | 8 | 2 | 0 | 1 | 14 | 13 | 1 | 0 | 88.1 | 62 | 23 | 22 | 4 | 23 | 89 | 9 | 0.96 | .194 | |
| Cory Wade | NYY | 3.38 | 0 | 1 | 0 | 1 | 30 | 0 | 0 | 0 | 29.1 | 26 | 12 | 11 | 4 | 6 | 30 | 0 | 1.09 | .232 | |
| Adam Wilk | DET | 8.18 | 0 | 3 | 0 | 0 | 3 | 3 | 0 | 0 | 11 | 21 | 11 | 10 | 4 | 3 | 7 | 0 | 2.18 | .412 | |
| C.J. Wilson | LAA | 2.44 | 8 | 4 | 0 | 0 | 15 | 15 | 0 | 0 | 92.1 | 67 | 31 | 25 | 4 | 39 | 79 | 12 | 1.15 | .203 | |
| 98 | Alfredo Aceves | BOS | 4.54 | 0 | 4 | 18 | 21 | 34 | 0 | 0 | 0 | 35.2 | 31 | 18 | 18 | 3 | 13 | 39 | 0 | 1.23 | .235 |
| Nate Adcock | KC | 3.12 | 0 | 3 | 0 | 0 | 9 | 2 | 0 | 0 | 26 | 31 | 10 | 9 | 3 | 10 | 13 | 0 | 1.58 | .307 | |
| Matt Albers | BOS | 1.88 | 2 | 0 | 0 | 3 | 26 | 0 | 0 | 0 | 28.2 | 21 | 10 | 6 | 3 | 7 | 19 | 0 | 0.98 | .200 | |
| Dylan Axelrod | CWS | 3.52 | 0 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 7.2 | 9 | 3 | 3 | 3 | 3 | 6 | 0 | 1.57 | .273 | |
| Grant Balfour | OAK | 2.75 | 1 | 1 | 7 | 9 | 35 | 0 | 0 | 0 | 36 | 23 | 11 | 11 | 3 | 15 | 29 | 0 | 1.06 | .185 | |
| Jerry Blevins | OAK | 2.37 | 1 | 0 | 0 | 0 | 25 | 0 | 0 | 0 | 30.1 | 23 | 10 | 8 | 3 | 11 | 25 | 0 | 1.12 | .225 | |
| Alex Burnett | MIN | 2.00 | 2 | 0 | 0 | 0 | 29 | 0 | 0 | 0 | 36 | 28 | 9 | 8 | 3 | 9 | 15 | 0 | 1.03 | .217 | |
| Tim Collins | KC | 2.27 | 4 | 1 | 0 | 0 | 32 | 0 | 0 | 0 | 35.2 | 22 | 9 | 9 | 3 | 13 | 51 | 0 | 0.98 | .173 | |
| Evan Crawford | TOR | 7.04 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 7.2 | 10 | 6 | 6 | 3 | 4 | 5 | 0 | 1.83 | .345 | |
| Wade Davis | TB | 2.25 | 1 | 0 | 0 | 0 | 23 | 0 | 0 | 0 | 32 | 26 | 8 | 8 | 3 | 12 | 33 | 0 | 1.19 | .215 | |
| Jason Frasor | TOR | 4.10 | 0 | 1 | 0 | 2 | 31 | 0 | 0 | 0 | 26.1 | 25 | 12 | 12 | 3 | 16 | 35 | 0 | 1.56 | .253 | |
| Nick Hagadone | CLE | 4.91 | 1 | 0 | 1 | 2 | 23 | 0 | 0 | 0 | 22 | 18 | 12 | 12 | 3 | 11 | 23 | 0 | 1.32 | .217 | |
| Jim Johnson | BAL | 1.14 | 1 | 0 | 21 | 22 | 31 | 0 | 0 | 0 | 31.2 | 15 | 4 | 4 | 3 | 6 | 19 | 0 | 0.66 | .140 | |
| Nate Jones | CWS | 3.21 | 3 | 0 | 0 | 0 | 27 | 0 | 0 | 0 | 33.2 | 31 | 12 | 12 | 3 | 11 | 33 | 0 | 1.25 | .248 | |
| Shawn Kelley | SEA | 4.12 | 1 | 2 | 0 | 1 | 21 | 0 | 0 | 0 | 19.2 | 25 | 13 | 9 | 3 | 7 | 22 | 0 | 1.63 | .305 | |
| Mark Lowe | TEX | 2.73 | 0 | 0 | 0 | 0 | 24 | 0 | 0 | 0 | 26.1 | 20 | 8 | 8 | 3 | 6 | 24 | 0 | 0.99 | .211 | |
| Luis Marte | DET | 4.15 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 13 | 13 | 6 | 6 | 3 | 2 | 11 | 0 | 1.15 | .260 | |
| Kevin Millwood | SEA | 4.02 | 3 | 6 | 0 | 0 | 14 | 14 | 1 | 1 | 80.2 | 79 | 43 | 36 | 3 | 33 | 59 | 6 | 1.39 | .257 | |
| Darren O'Day | BAL | 1.72 | 4 | 0 | 0 | 1 | 30 | 0 | 0 | 0 | 31.1 | 21 | 6 | 6 | 3 | 4 | 32 | 0 | 0.80 | .189 | |
| Troy Patton | BAL | 3.45 | 1 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 31.1 | 26 | 12 | 12 | 3 | 6 | 28 | 0 | 1.02 | .222 | |
| Felipe Paulino | KC | 1.67 | 3 | 1 | 0 | 0 | 7 | 7 | 0 | 0 | 37.2 | 31 | 8 | 7 | 3 | 15 | 39 | 4 | 1.22 | .223 | |
| Luis Perez | TOR | 3.28 | 2 | 1 | 0 | 0 | 29 | 0 | 0 | 0 | 35.2 | 32 | 13 | 13 | 3 | 15 | 33 | 0 | 1.32 | .244 | |
| Glen Perkins | MIN | 2.93 | 1 | 1 | 2 | 4 | 32 | 0 | 0 | 0 | 30.2 | 28 | 12 | 10 | 3 | 13 | 40 | 0 | 1.34 | .248 | |
| Erasmo Ramirez | SEA | 5.40 | 0 | 1 | 0 | 0 | 9 | 2 | 0 | 0 | 20 | 24 | 14 | 12 | 3 | 6 | 13 | 0 | 1.50 | .293 | |
| Esmil Rogers | CLE | 6.89 | 0 | 2 | 0 | 2 | 27 | 0 | 0 | 0 | 31.1 | 39 | 25 | 24 | 3 | 18 | 36 | 0 | 1.82 | .295 | |
| Jonathan Sanchez | KC | 5.70 | 1 | 3 | 0 | 0 | 8 | 8 | 0 | 0 | 36.1 | 38 | 24 | 23 | 3 | 28 | 25 | 1 | 1.82 | .273 | |
| Daniel Schlereth | DET | 10.29 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 7 | 14 | 10 | 8 | 3 | 5 | 6 | 0 | 2.71 | .412 | |
| Hisanori Takahashi | LAA | 4.32 | 0 | 2 | 0 | 1 | 24 | 0 | 0 | 0 | 25 | 23 | 12 | 12 | 3 | 6 | 21 | 0 | 1.16 | .247 | |
| Yoshinori Tateyama | TEX | 11.88 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 8.1 | 12 | 13 | 11 | 3 | 3 | 8 | 0 | 1.80 | .308 | |
| Koji Uehara | TEX | 2.11 | 0 | 0 | 0 | 0 | 20 | 0 | 0 | 0 | 21.1 | 13 | 5 | 5 | 3 | 2 | 22 | 0 | 0.70 | .171 | |
| Dan Wheeler | CLE | 8.76 | 0 | 0 | 0 | 0 | 12 | 0 | 0 | 0 | 12.1 | 17 | 12 | 12 | 3 | 7 | 2 | 0 | 1.95 | .327 | |
| Tom Wilhelmsen | SEA | 3.00 | 3 | 1 | 5 | 6 | 32 | 0 | 0 | 0 | 36 | 29 | 14 | 12 | 3 | 11 | 44 | 0 | 1.11 | .216 | |
| 130 | Luis Ayala | BAL | 1.95 | 2 | 1 | 1 | 3 | 28 | 0 | 0 | 0 | 32.1 | 29 | 9 | 7 | 2 | 6 | 22 | 0 | 1.08 | .230 |
| Duane Below | DET | 2.35 | 2 | 1 | 0 | 0 | 20 | 0 | 0 | 0 | 30.2 | 23 | 8 | 8 | 2 | 3 | 20 | 0 | 0.85 | .215 | |
| Jason Berken | BAL | 18.00 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6 | 7 | 2 | 2 | 1 | 0 | 0 | 7.00 | .667 | |
| Bobby Cassevah | LAA | 7.20 | 1 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 5 | 5 | 4 | 4 | 2 | 6 | 2 | 0 | 2.20 | .263 | |
| Brett Cecil | TOR | 3.60 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 5 | 5 | 2 | 2 | 2 | 1 | 5 | 0 | 1.20 | .250 | |
| Alex Cobb | TB | 3.82 | 3 | 3 | 0 | 0 | 6 | 6 | 0 | 0 | 37.2 | 32 | 18 | 16 | 2 | 12 | 32 | 2 | 1.17 | .227 | |
| Robert Coello | TOR | 8.53 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 0 | 6.1 | 9 | 6 | 6 | 2 | 3 | 11 | 0 | 1.89 | .333 | |
| Jesse Crain | CWS | 2.45 | 1 | 1 | 0 | 3 | 23 | 0 | 0 | 0 | 22 | 16 | 7 | 6 | 2 | 8 | 26 | 0 | 1.09 | .195 | |
| Casey Crosby | DET | 9.49 | 1 | 1 | 0 | 0 | 3 | 3 | 0 | 0 | 12.1 | 15 | 13 | 13 | 2 | 11 | 9 | 0 | 2.11 | .313 | |
| Octavio Dotel | DET | 4.19 | 1 | 2 | 1 | 3 | 22 | 0 | 0 | 0 | 19.1 | 14 | 9 | 9 | 2 | 6 | 29 | 0 | 1.03 | .194 | |
| Danny Duffy | KC | 3.90 | 2 | 2 | 0 | 0 | 6 | 6 | 0 | 0 | 27.2 | 26 | 13 | 12 | 2 | 18 | 28 | 2 | 1.59 | .252 | |
| Ernesto Frieri | LAA | 0.84 | 1 | 0 | 8 | 8 | 32 | 0 | 0 | 0 | 32.1 | 12 | 5 | 3 | 2 | 18 | 54 | 0 | 0.93 | .112 | |
| Charlie Furbush | SEA | 2.15 | 3 | 1 | 0 | 0 | 26 | 0 | 0 | 0 | 29.1 | 13 | 7 | 7 | 2 | 5 | 37 | 0 | 0.61 | .130 | |
| Kevin Gregg | BAL | 4.82 | 2 | 2 | 0 | 0 | 17 | 0 | 0 | 0 | 18.2 | 20 | 10 | 10 | 2 | 9 | 17 | 0 | 1.55 | .278 | |
| Aaron Laffey | TOR | 3.00 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 9 | 6 | 3 | 3 | 2 | 2 | 4 | 0 | 0.89 | .188 | |
| Boone Logan | NYY | 2.81 | 1 | 0 | 1 | 1 | 35 | 0 | 0 | 0 | 25.2 | 23 | 8 | 8 | 2 | 10 | 33 | 0 | 1.29 | .240 | |
| Matt Maloney | MIN | 8.18 | 1 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 11 | 17 | 10 | 10 | 2 | 1 | 5 | 0 | 1.64 | .347 | |
| Daisuke Matsuzaka | BOS | 6.06 | 0 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 16.1 | 13 | 11 | 11 | 2 | 5 | 15 | 1 | 1.10 | .213 | |
| Jose Mijares | KC | 1.95 | 2 | 1 | 0 | 1 | 35 | 0 | 0 | 0 | 27.2 | 26 | 7 | 6 | 2 | 5 | 27 | 0 | 1.12 | .248 | |
| Jim Miller | OAK | 1.29 | 1 | 0 | 0 | 0 | 14 | 0 | 0 | 0 | 21 | 17 | 3 | 3 | 2 | 9 | 18 | 0 | 1.24 | .224 | |
| Franklin Morales | BOS | 3.14 | 0 | 1 | 0 | 0 | 23 | 1 | 0 | 0 | 28.2 | 25 | 10 | 10 | 2 | 8 | 29 | 0 | 1.15 | .231 | |
| Clayton Mortensen | BOS | 1.54 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 11.2 | 9 | 2 | 2 | 2 | 0 | 12 | 0 | 0.77 | .209 | |
| Joe Nathan | TEX | 1.52 | 0 | 2 | 16 | 17 | 30 | 0 | 0 | 0 | 29.2 | 23 | 6 | 5 | 2 | 2 | 36 | 0 | 0.84 | .213 | |
| Jeff Niemann | TB | 3.38 | 2 | 3 | 0 | 0 | 7 | 7 | 0 | 0 | 34.2 | 29 | 17 | 13 | 2 | 12 | 30 | 1 | 1.18 | .221 | |
| Alexi Ogando | TEX | 2.08 | 1 | 0 | 1 | 3 | 28 | 1 | 0 | 0 | 34.2 | 21 | 8 | 8 | 2 | 7 | 35 | 0 | 0.81 | .175 | |
| Vicente Padilla | BOS | 4.15 | 1 | 0 | 1 | 2 | 26 | 0 | 0 | 0 | 26 | 29 | 13 | 12 | 2 | 6 | 25 | 0 | 1.35 | .282 | |
| Jarrod Parker | OAK | 2.70 | 3 | 3 | 0 | 0 | 11 | 11 | 0 | 0 | 66.2 | 50 | 20 | 20 | 2 | 32 | 49 | 8 | 1.23 | .214 | |
| Vinnie Pestano | CLE | 1.86 | 3 | 0 | 0 | 1 | 31 | 0 | 0 | 0 | 29 | 16 | 6 | 6 | 2 | 13 | 35 | 0 | 1.00 | .157 | |
| Jose Quintana | CWS | 1.53 | 2 | 1 | 0 | 0 | 7 | 5 | 0 | 0 | 35.1 | 30 | 6 | 6 | 2 | 6 | 20 | 3 | 1.02 | .238 | |
| Robbie Ross | TEX | 1.15 | 6 | 0 | 0 | 0 | 27 | 0 | 0 | 0 | 39 | 30 | 10 | 5 | 2 | 6 | 25 | 0 | 0.92 | .221 | |
| Tanner Scheppers | TEX | 11.81 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 5.1 | 11 | 7 | 7 | 2 | 1 | 6 | 0 | 2.25 | .407 | |
| George Sherrill | SEA | 27.00 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1.1 | 6 | 4 | 4 | 2 | 1 | 0 | 0 | 5.25 | .667 | |
| Joe Smith | CLE | 3.56 | 5 | 1 | 0 | 1 | 32 | 0 | 0 | 0 | 30.1 | 26 | 13 | 12 | 2 | 13 | 26 | 0 | 1.29 | .236 | |
| Everett Teaford | KC | 5.73 | 0 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 11 | 11 | 7 | 7 | 2 | 7 | 4 | 0 | 1.64 | .275 | |
| Matt Thornton | CWS | 3.23 | 2 | 5 | 1 | 4 | 35 | 0 | 0 | 0 | 30.2 | 30 | 12 | 11 | 2 | 9 | 27 | 0 | 1.27 | .254 | |
| Jose Valverde | DET | 4.18 | 3 | 2 | 13 | 16 | 29 | 0 | 0 | 0 | 28 | 25 | 18 | 13 | 2 | 17 | 19 | 0 | 1.50 | .238 | |
| 166 | Mike Adams | TEX | 3.00 | 1 | 2 | 1 | 2 | 29 | 0 | 0 | 0 | 24 | 25 | 10 | 8 | 1 | 5 | 19 | 0 | 1.25 | .263 |
| Scott Atchison | BOS | 1.17 | 2 | 0 | 0 | 1 | 29 | 0 | 0 | 0 | 38.1 | 27 | 5 | 5 | 1 | 7 | 29 | 0 | 0.89 | .199 | |
| Scott Barnes | CLE | 10.38 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 4.1 | 5 | 5 | 5 | 1 | 4 | 4 | 0 | 2.08 | .263 | |
| Chad Beck | TOR | 3.38 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 5.1 | 4 | 3 | 2 | 1 | 2 | 4 | 0 | 1.13 | .200 | |
| Joaquin Benoit | DET | 1.93 | 1 | 1 | 1 | 2 | 33 | 0 | 0 | 0 | 32.2 | 26 | 9 | 7 | 1 | 14 | 44 | 0 | 1.22 | .222 | |
| Travis Blackley | OAK | 3.89 | 1 | 2 | 0 | 0 | 12 | 5 | 0 | 0 | 39.1 | 35 | 20 | 17 | 1 | 10 | 25 | 2 | 1.14 | .236 | |
| Jonathan Broxton | KC | 1.57 | 1 | 1 | 18 | 21 | 28 | 0 | 0 | 0 | 28.2 | 27 | 7 | 5 | 1 | 10 | 22 | 0 | 1.29 | .255 | |
| David Carpenter | LAA | 4.98 | 1 | 1 | 0 | 0 | 18 | 0 | 0 | 0 | 21.2 | 26 | 12 | 12 | 1 | 9 | 19 | 0 | 1.62 | .310 | |
| Jesse Chavez | TOR | 8.22 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 7.2 | 7 | 7 | 7 | 1 | 4 | 11 | 0 | 1.43 | .233 | |
| Phil Coke | DET | 3.45 | 1 | 3 | 1 | 2 | 33 | 0 | 0 | 0 | 31.1 | 37 | 15 | 12 | 1 | 8 | 29 | 0 | 1.44 | .303 | |
| Aaron Cook | BOS | 20.25 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 2.2 | 8 | 7 | 6 | 1 | 1 | 0 | 0 | 3.38 | .533 | |
| Aaron Crow | KC | 2.73 | 0 | 1 | 1 | 3 | 33 | 0 | 0 | 0 | 29.2 | 23 | 10 | 9 | 1 | 12 | 28 | 0 | 1.18 | .215 | |
| Dane De La Rosa | TB | 45.00 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 5 | 5 | 1 | 2 | 0 | 0 | 6.00 | .667 | |
| Brian Duensing | MIN | 3.12 | 1 | 2 | 0 | 0 | 30 | 0 | 0 | 0 | 34.2 | 28 | 12 | 12 | 1 | 9 | 22 | 0 | 1.07 | .224 | |
| Cody Eppley | NYY | 2.55 | 0 | 0 | 0 | 0 | 21 | 0 | 0 | 0 | 17.2 | 14 | 5 | 5 | 1 | 8 | 9 | 0 | 1.25 | .226 | |
| Dana Eveland | BAL | 3.24 | 0 | 0 | 0 | 0 | 10 | 1 | 0 | 0 | 25 | 22 | 10 | 9 | 1 | 11 | 13 | 1 | 1.32 | .239 | |
| Pedro Figueroa | OAK | 1.50 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 12 | 7 | 2 | 2 | 1 | 9 | 5 | 0 | 1.33 | .189 | |
| Brandon Gomes | TB | 5.87 | 1 | 2 | 0 | 0 | 7 | 0 | 0 | 0 | 7.2 | 6 | 5 | 5 | 1 | 8 | 10 | 0 | 1.83 | .207 | |
| Justin Grimm | TEX | 4.50 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 6 | 6 | 3 | 3 | 1 | 0 | 7 | 1 | 1.00 | .261 | |
| Tommy Hottovy | KC | 3.38 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 5.1 | 5 | 2 | 2 | 1 | 1 | 5 | 0 | 1.13 | .263 | |
| Jason Isringhausen | LAA | 1.73 | 2 | 0 | 0 | 1 | 27 | 0 | 0 | 0 | 26 | 17 | 5 | 5 | 1 | 12 | 17 | 0 | 1.12 | .179 | |
| Kevin Jepsen | LAA | 10.29 | 0 | 1 | 0 | 2 | 9 | 0 | 0 | 0 | 7 | 9 | 9 | 8 | 1 | 2 | 4 | 0 | 1.57 | .346 | |
| Brandon League | SEA | 3.77 | 0 | 4 | 9 | 13 | 31 | 0 | 0 | 0 | 31 | 33 | 14 | 13 | 1 | 15 | 20 | 0 | 1.55 | .280 | |
| Zach McAllister | CLE | 3.96 | 1 | 1 | 0 | 0 | 4 | 4 | 0 | 0 | 25 | 25 | 14 | 11 | 1 | 6 | 22 | 2 | 1.24 | .255 | |
| Darnell McDonald | BOS | 27.00 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3 | 3 | 1 | 2 | 0 | 0 | 4.00 | .500 | |
| Andrew Miller | BOS | 2.40 | 1 | 0 | 0 | 0 | 18 | 0 | 0 | 0 | 15 | 8 | 4 | 4 | 1 | 6 | 17 | 0 | 0.93 | .160 | |
| Jordan Norberto | OAK | 3.91 | 0 | 1 | 1 | 2 | 21 | 0 | 0 | 0 | 25.1 | 16 | 11 | 11 | 1 | 12 | 18 | 0 | 1.11 | .184 | |
| Darren Oliver | TOR | 1.48 | 1 | 2 | 0 | 1 | 28 | 0 | 0 | 0 | 24.1 | 16 | 4 | 4 | 1 | 7 | 26 | 0 | 0.95 | .190 | |
| David Pauley | TOR | 3.97 | 0 | 1 | 0 | 0 | 6 | 0 | 0 | 0 | 11.1 | 17 | 6 | 5 | 1 | 4 | 4 | 0 | 1.85 | .347 | |
| Rafael Perez | CLE | 3.52 | 1 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | 7.2 | 5 | 3 | 3 | 1 | 4 | 4 | 0 | 1.17 | .185 | |
| Zach Phillips | BAL | 27.00 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.2 | 3 | 2 | 2 | 1 | 2 | 0 | 0 | 7.50 | .600 | |
| Stu Pomeranz | BAL | 3.00 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 6 | 7 | 2 | 2 | 1 | 1 | 3 | 0 | 1.33 | .280 | |
| Stephen Pryor | SEA | 1.69 | 1 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 5.1 | 4 | 1 | 1 | 1 | 3 | 5 | 0 | 1.31 | .222 | |
| Cesar Ramos | TB | 2.08 | 1 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 17.1 | 12 | 4 | 4 | 1 | 6 | 15 | 0 | 1.04 | .185 | |
| Clay Rapada | NYY | 2.95 | 1 | 0 | 0 | 0 | 31 | 0 | 0 | 0 | 21.1 | 11 | 8 | 7 | 1 | 13 | 19 | 0 | 1.13 | .159 | |
| Addison Reed | CWS | 4.18 | 1 | 1 | 8 | 9 | 27 | 0 | 0 | 0 | 23.2 | 20 | 11 | 11 | 1 | 9 | 26 | 0 | 1.23 | .222 | |
| Garrett Richards | LAA | 0.86 | 2 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 21 | 13 | 3 | 2 | 1 | 11 | 17 | 2 | 1.14 | .183 | |
| David Robertson | NYY | 2.76 | 0 | 1 | 1 | 2 | 17 | 0 | 0 | 0 | 16.1 | 14 | 5 | 5 | 1 | 6 | 26 | 0 | 1.22 | .230 | |
| Fernando Rodney | TB | 1.10 | 2 | 1 | 20 | 21 | 34 | 0 | 0 | 0 | 32.2 | 20 | 6 | 4 | 1 | 5 | 31 | 0 | 0.77 | .174 | |
| Sergio Santos | TOR | 9.00 | 0 | 1 | 2 | 4 | 6 | 0 | 0 | 0 | 5 | 6 | 5 | 5 | 1 | 4 | 4 | 0 | 2.00 | .316 | |
| Pedro Strop | BAL | 1.38 | 3 | 2 | 3 | 6 | 29 | 0 | 0 | 0 | 32.2 | 19 | 5 | 5 | 1 | 18 | 28 | 0 | 1.13 | .174 | |
| Rich Thompson | OAK | 12.00 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 3 | 6 | 4 | 4 | 1 | 1 | 3 | 0 | 2.33 | .400 | |
| Brayan Villarreal | DET | 1.16 | 3 | 1 | 0 | 0 | 20 | 0 | 0 | 0 | 23.1 | 10 | 6 | 3 | 1 | 10 | 34 | 0 | 0.86 | .128 | |
| Jordan Walden | LAA | 2.86 | 2 | 1 | 1 | 2 | 25 | 0 | 0 | 0 | 22 | 18 | 7 | 7 | 1 | 13 | 25 | 0 | 1.41 | .214 |